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Acute suppurative sinusitis in rabbits has been produced success-
{ully by introducing Strebtococcus hemolyiicus into the antrum (1).
Such a procedure, however. is not applicable to the production of
diphtheritic sinusitis in these animals since it is well known that the
mere presence of C. diphtheriae on the mucosa of the upper respiratory
tract fails to lead to the invasion of the tissues by this organism.
Lesions can be induced only when the mucous membrane prewously has
been damaged before the organisms are introduced. Even then
pathologicaJ changes are not constantly observed and it is questionable
whether the pseudomembrane thus produced corresponds histologically
to that of the false membrane observed in patients suffering from
diphtheria (2). Since there are many interesting and unsolved problems
associated with the clinical manifestations of this disease, it appeared
worthwhile to make further efforts to produce experimental diphtheritic
infection in animals in order that some of these problems might be
subjected to controlled investigation. 相似文献
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