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排序方式: 共有559条查询结果,搜索用时 31 毫秒
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Hematological profile of HIV positive patients 总被引:4,自引:0,他引:4
Patwardhan MS Golwilkar AS Abhyankar JR Atre MC 《Indian journal of pathology & microbiology》2002,45(2):147-150
A series of 500 HIV positive patients referred to our centre for CD4 and CD8 cell enumeration are included in this study. The following parameters were studied in each of these patients: Hb, RBC indicates, WBC count, platelet count, three part differential count, absolute CD4 and CD8 counts. Male:Female ratio of 4.9:1 was noted 30.8% patients has anemia (Hb<10 gm%), with an average Hb value of 8.1 gm%. The anemia was normochromic, normocytic in 61% of patients, microcytic in 33% and macrocytic in 6% patients. The absolute CD4 count was less than 200 ul in 50.2% patients with an average value of 92/ul. Thrombocytopenia was seen in 13% patients with average platelet count 0.92x10(3)/ul. 相似文献
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G. Padma N. Swapna M. Mamata Bh. Charita T. Padma 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2014,36(8):579-585
Introduction: AGT gene harbors several variants of which 21 are found to be in high linkage disequilibrium as per Hapmap database. Studies delineating the importance of these tagged SNPs are very limited and lacking from Indian population. In the present study, we evaluated the contribution of four tagged SNPs namely, g.6635G?>?A, g.6506G?>?A, g.12840G?>?A, and g.13828T?>?C at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to essential hypertension (EHT).Methods: About 215 hypertensives and 230 normotensives were genotyped for selected tagged SNPs using PCR-RFLP method.Results: Significant association was obtained for g.6635G?>?A and g.6506G?>?A polymorphisms wherein GG homozygotes for both the markers were at risk for developing the condition. g.13828T?>?C polymorphism specially, female heterozygotes (TC) were found to be at increased risk for EHT. Haplotype GGGC was found to have a significant protective effect (p?=?0.0059). Markers g.6506G?>?A and g.12840G?>?A resulted in the creation of new enhancer sites thereby affecting splicing process.Conclusion: The present report is the first one in the literature showing general- and gender-specific association of g.6506G?>?A and g.13828T?>?C polymorphisms, respectively, with EHT. However, further studies for replication of present observations are warranted from other populations and other parts of India. 相似文献
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Chutika Srisuttiyakorn Jennifer Reeve Swapna Reddy Suguru Imaeda Rossitza Lazova 《Journal of cutaneous pathology》2014,41(5):475-479
Subcutaneous histiocytoid Sweet's syndrome is a rare variant of histiocytoid Sweet's syndrome (SS). We present a 68‐year‐old woman with subcutaneous histiocytoid SS in association with refractory myelodysplastic syndrome transformed to acute myeloblastic leukemia (AML), status post induction chemotherapy and with persistent blasts (50%) in the bone marrow and blood, accompanied with neutropenia. The patient presented to the emergency room with fever and altered mental status. Clinical examination revealed approximately 20 scattered 0.5–2 cm, pink to pink‐purple non‐tender firm nodules on the legs and left arm. The differential diagnosis included Sweet's syndrome (deep), leukemia cutis, infection, polyarteritis nodosa and erythema nodosum. Histopathologic examination of a biopsy from the left arm revealed a nodular infiltrate of neutrophils and histiocytoid mononuclear cells solely in the lobular compartment of the subcutaneous fat with focal areas of necrosis. Most cells in the infiltrate labeled with myeloperoxidase (MPO) including the histiocytoid cells. The cells were negative for CD34 and CD117. All special stains for microorganisms were negative. A diagnosis of subcutaneous histiocytoid SS was made. A subcutaneous histiocytoid SS should be suspected when a neutrophilic/histiocytoid panniculitis, occurring in the setting of myeloid disorders, is encountered and after exclusion of an infectious process and leukemia cutis. 相似文献
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Advances in the therapy of chronic lymphocytic leukemia 总被引:1,自引:0,他引:1
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Kazimierz O. Wrzeszczynski Vanessa Felice Avinash Abhyankar Lukasz Kozon Heather Geiger Dina Manaa Ferrah London Dino Robinson Xiaolan Fang David Lin Michelle F. Lamendola-Essel Depinder Khaira Esra Dikoglu Anne-Katrin Emde Nicolas Robine Minita Shah Kanika Arora Olca Basturk Vaidehi Jobanputra 《The Journal of molecular diagnostics : JMD》2018,20(6):822-835
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Apheresis buffy coat collection without photoactivation has no effect on apoptosis,cell proliferation,and total viability of mononuclear cells collected using photopheresis systems 下载免费PDF全文
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Angela Fagerlin Michael Pignone Purva Abhyankar Nananda Col Deb Feldman-Stewart Teresa Gavaruzzi Jennifer Kryworuchko Carrie A Levin Arwen H Pieterse Valerie Reyna Anne Stiggelbout Laura D Scherer Celia Wills Holly O Witteman 《BMC medical informatics and decision making》2013,13(Z2):S8