全文获取类型
收费全文 | 870篇 |
免费 | 49篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 36篇 |
妇产科学 | 24篇 |
基础医学 | 97篇 |
口腔科学 | 16篇 |
临床医学 | 85篇 |
内科学 | 125篇 |
皮肤病学 | 12篇 |
神经病学 | 56篇 |
特种医学 | 27篇 |
外科学 | 59篇 |
综合类 | 60篇 |
预防医学 | 81篇 |
眼科学 | 5篇 |
药学 | 206篇 |
中国医学 | 19篇 |
肿瘤学 | 45篇 |
出版年
2023年 | 7篇 |
2022年 | 15篇 |
2021年 | 28篇 |
2020年 | 22篇 |
2019年 | 24篇 |
2018年 | 25篇 |
2017年 | 18篇 |
2016年 | 21篇 |
2015年 | 17篇 |
2014年 | 35篇 |
2013年 | 54篇 |
2012年 | 81篇 |
2011年 | 63篇 |
2010年 | 38篇 |
2009年 | 25篇 |
2008年 | 41篇 |
2007年 | 73篇 |
2006年 | 51篇 |
2005年 | 38篇 |
2004年 | 38篇 |
2003年 | 32篇 |
2002年 | 22篇 |
2001年 | 19篇 |
2000年 | 20篇 |
1999年 | 8篇 |
1998年 | 13篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 12篇 |
1994年 | 5篇 |
1993年 | 6篇 |
1992年 | 12篇 |
1991年 | 8篇 |
1990年 | 11篇 |
1989年 | 5篇 |
1988年 | 8篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1977年 | 2篇 |
1974年 | 11篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1966年 | 2篇 |
1954年 | 1篇 |
1932年 | 1篇 |
排序方式: 共有956条查询结果,搜索用时 15 毫秒
1.
CTLA4-Ig是一种融合免疫球蛋白,可以选择性地阻断CD28与B7的信号传导通路,导致T细胞免疫失能,诱导对特异性抗原的免疫耐受. 本文介绍了其生物学特性、免疫诱导耐受机制及在异体移植方面的研究进展和局限性,其在异体移植方面展示了良好的应用前景. 相似文献
2.
3.
新生儿和儿童乙肝免疫 总被引:3,自引:1,他引:2
陈仕珠 《世界华人消化杂志》2006,14(27):2708-2712
自1991年WHO提出将乙型肝炎病毒(HBV)疫苗纳入新生儿计划免疫以来,绝大多数国家新生儿HBV疫苗接种覆盖率平均在90%以上,婴儿HBV疫苗接种覆盖率为85%-99%.我国HBsAg携带率从10.19%下降到0.2%-3.2%.不同地区新生儿和儿童全程接种率、首针及时接种率、免疫覆盖率差异较大.对不同新生儿和儿童HB免疫尚需注意的问题如HBV疫苗接种程序和接种剂量,早产、低体质量儿的免疫接种,HBsAg阳性母亲子女的免疫接种和母乳喂养,抗-HBs保护时间和加强免疫问题. 相似文献
4.
A wide variety of health care options--home-based, indigenous, and cosmopolitan--exists in northern Balochistan, Pakistan. This paper examines health-seeking behavior in the area of mother and child health for villagers in this pluralistic medical setting. The analysis of a specific series of illness episodes shows that the majority of cases obtain treatment from different medical systems for a single episode. Interest in medications takes precedence over practitioners, and the meaning the villagers attach to such substances is explored. Long-established patterns of behavior relating to indigenous medicine continue to occur when cosmopolitan medicine is utilized. Information presented here helps to explain problems in utilization of cosmopolitan pharmaceuticals and delineates areas for future health programme activity. 相似文献
5.
Eva Maria Cutiongco‐de la Paz Brian Hon‐Yin Chung Sultana M. H. Faradz Meow‐Keong Thong Carmencita David‐Padilla Poh San Lai Shuan‐Pei Lin Yin‐Hsiu Chen Thanyachai Sura Mercy Laurino 《American journal of medical genetics. Part C, Seminars in medical genetics》2019,181(2):177-186
The status of training in clinical genetics and genetic counseling in Asia is at diverse stages of development and maturity. Most of the training programs are in academic training centers where exposure to patients in the clinics or in the hospital is a major component. This setting provides trainees with knowledge and skills to be competent geneticists and genetic counselors in a variety of patient care interactions. Majority of the training programs combine clinical and research training which provide trainees a broad and integrated approach in the diagnosis and management of patients while providing opportunities for research discoveries that can be translated to better patient care. The background on how the training programs in clinical genetics and genetic counseling in Asia evolved to their current status are described. Each of these countries can learn from each other through sharing of best practices and resources. 相似文献
6.
Gonadoblastoma is a rare tumor arising in the streak gonads of about 30% of 46, XY sex-reversed females. Because gonadoblastoma develops only in patients who have Y-chromosome material and dysgenetic gonads, it has been hypothesized that positive expression of a gene (or genes) on the Y chromosome (GBY) is involved in the etiology of the tumor. To examine the Y chromosome directly in tumors, we performed nonisotopic in situ hybridization of a biotin-labeled Y-specific probe for the DYZI locus on formalin-fixed, paraffin-embedded sections of tumor samples from four different patients. After hybridization to DYZI, the Y chromosome was found to be present in all gonadoblastoma foci in the four patients studied, and the gonadoblastoma foci showed an average of 85% cell nuclei positive for the Y chromosome on tissue sections. Normal male and female control tissues showed an average of 78% and 0% positive nuclei, respectively. One patient with bilateral gonadoblastoma had previously been shown to be mosaic, with a 45, X/46, XY karyotype in lymphocytes, skin fibroblasts, and cultures from both gonads. Examination of sections of this patient's gonads showed 79% positive nuclei within the gonadoblastoma foci, whereas the nontumor stromal tissue had 19% positive nuclei. These results indicate that, in this mosaic gonad, tumor foci developed only from cells that had a Y chromosome. Our results support the hypothesis that there is a GBY locus on the Y chromosome and that the Y chromosome is retained in the gonadoblastoma foci during the development of the tumor. © 1995 Wiley-Liss, Inc. 相似文献
7.
Summary The venous architecture in donor flaps was observed in 17 fresh cadavers by injection of latex or ink into the vessels or by making corrosion-cast specimens. The pattern of the veins resembles that of the arteries, with the difference that there is another set of venous trunks which do not accompany the arteries. Because these trunks are of larger caliber, they are the main drainage route for flaps. There are three types of drainage based on the anatomical architecture: 1) the superficial trunk is the main drainage path; 2) the deep trunk is the main path; 3) both superficial and deep veins are involved. These morphological considerations are the basis for selection of veins for anastomosis in microsurgery. The axial veins in temporal, frontal and facial flaps on the dorsum of the hand and the foot usually loosely accompany the axial arteries. The characteristics of these vascular pedicules should be studied in transplant operation.
Bases anatomiques du drainage veineux des lambeaux cutanés libres
Résumé Le drainage veineux des lambeaux cutanés libres a été étudié sur 17 cadavres frais par injection de latex ou d'encre dans les vaisseaux, ou en réalisant des moulages par injection-corrosion. La distribution des veines ressemble à celle des artères à la différence près qu'il existe des troncs veineux qui n'accompagnent pas les artères. Ces troncs ont un calibre plus important et représentent une voie de drainage principale pour les lambeaux. On peut individualiser trois types de drainages basés sur l'architecture veineuse : 1. Le tronc superficiel est la principale voie de drainage ; 2. le tronc profond est la principale voie; 3. les veines superficielles et profondes sont impliquées simultanément. Ces considérations morphologiques sont les bases de la sélection des axes veineux pour les anastomoses en micro-chirurgie. Les veines axiales au niveau temporal, frontal et facial et pour les lambeaux de la face dorsale de la main et du pied sont habituellement relativement éloignées du trajet artériel. Les caractéristiques de ces pédicules veineux doivent être précisées pour la réalisation des lambeaux.相似文献
8.
Development of nested PCR based on the ViaB sequence to detect Salmonella typhi. 总被引:1,自引:3,他引:1
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Y Hashimoto Y Itho Y Fujinaga A Q Khan F Sultana M Miyake K Hirose H Yamamoto T Ezaki 《Journal of clinical microbiology》1995,33(3):775-777
For a rapid diagnosis of typhoid fever, we developed a nested PCR based on the nucleotide sequence encoding the Vi antigen. All Salmonella typhi strains along with a Salmonella paratyphi C strain were PCR positive. This assay was able to detect S. typhi at the single-cell level. 相似文献
9.
10.