全文获取类型
收费全文 | 174篇 |
免费 | 21篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 15篇 |
妇产科学 | 5篇 |
基础医学 | 36篇 |
口腔科学 | 1篇 |
临床医学 | 18篇 |
内科学 | 26篇 |
皮肤病学 | 2篇 |
神经病学 | 10篇 |
外科学 | 8篇 |
综合类 | 3篇 |
预防医学 | 32篇 |
眼科学 | 16篇 |
药学 | 16篇 |
中国医学 | 1篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 5篇 |
2019年 | 11篇 |
2018年 | 10篇 |
2017年 | 2篇 |
2016年 | 15篇 |
2015年 | 7篇 |
2014年 | 11篇 |
2013年 | 12篇 |
2012年 | 14篇 |
2011年 | 14篇 |
2010年 | 12篇 |
2009年 | 7篇 |
2008年 | 15篇 |
2007年 | 10篇 |
2006年 | 10篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 6篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1991年 | 1篇 |
排序方式: 共有195条查询结果,搜索用时 46 毫秒
1.
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency. 总被引:1,自引:0,他引:1
Nima Parvaneh Shohreh Shahmahmoudi Hamideh Tabatabai Mohsen Zahraei Taha Mousavi Abdol-Reza Esteghamati Mohammad M Gooya Setareh Mamishi Rakhshandeh Nategh Olen M Kew 《Journal of clinical virology》2007,39(2):145-148
Vaccine-associated paralytic poliomyelitis (VAPP) is a rare complication of oral polio vaccine. We describe a fatal case of VAPP in an 8-month-old boy with Major Histocompatibility Class II deficiency. The isolated poliovirus was a Sabin type 2-type 1 recombinant that showed 1.4% VP1 divergence from Sabin type 2. 相似文献
2.
3.
Williams SA Shi L Brenneman SK Johnson JC Wegner JC Fonseca V 《Journal of diabetes and its complications》2012,26(5):399-406
ObjectiveTo assess the burden of hypoglycemia among type 2 diabetes patients on antidiabetic drugs with or without use of insulin.Research Design and MethodsWe used mail surveys, administrative claims data, and enrollment information from a sample of adult commercial health plan enrollees (n = 813) with type 2 diabetes during a 12-month period. Patients' experience of hypoglycemia, its impact on patient perspectives and healthcare utilization were the outcomes evaluated.ResultsA greater percentage of patients in the antidiabetic with insulin cohort reported experiencing hypoglycemia compared with patients from sulfonylurea (SU) without insulin and non-SU without insulin cohorts (50% vs. 21% and 12%, respectively; p < 0.01 for both comparisons). While 71% of the sample reported experiencing hypoglycemic symptoms with 28% confirmed by low blood glucose levels, only 10% of the patients had evidence of hypoglycemia event in the claims database. Patients with confirmed hypoglycemia had the highest Hypoglycemia Fear Survey behavior score (8) and worry subscale score (14). Significant differences were noted between the confirmed hypoglycemia and no hypoglycemia cohorts for the 12-item Short Form Health Survey's Mental Component Score (p < 0.001) and Physical Component Score (p = 0.002), and for the EQ-5D index (p < 0.001). Diabetes-related annualized mean total healthcare costs were significantly higher for confirmed hypoglycemia vs. no hypoglycemia cohorts (p = 0.004).ConclusionsSymptomatic hypoglycemia is a more significant burden among type 2 diabetes patients treated with antidiabetic drugs than is estimated by administrative claims data and needs to be considered when choosing therapy. 相似文献
4.
Synthesis and anticholinesterase activity of new substituted benzo[d]oxazole‐based derivatives 下载免费PDF全文
Behjat Pouramiri Setareh Moghimi Mohammad Mahdavi Hamid Nadri Alireza Moradi Esmat Tavakolinejad‐Kermani Loghman Firoozpour Ali Asadipour Alireza Foroumadi 《Chemical biology & drug design》2017,89(5):783-789
A series of novel benzo[d]oxazole derivatives ( 6a–n ) have been synthesized and biologically evaluated as potential inhibitors of acetylcholinesterases (AChE) and butyrylcholinesterase (BChE). The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro studies showed that most of the synthesized compounds are potent acetylcholinesterase and butyrylcholinesterase inhibitors. Among them, compounds 6a and 6j strongly inhibited AChE and BChE activities with IC50 values of 1.03–1.35 and 6.6–8.1 μm , respectively. Docking studies also provided the binding modes of action and identified hydrophobic pi forces as the main interaction. 相似文献
5.
Soroor Golnoosh Mokhtari Setareh Pouretemad Hamidreza 《Journal of autism and developmental disorders》2022,52(3):1019-1029
Journal of Autism and Developmental Disorders - We investigated (1) if the perceptual integration performance is different in children with ASD in comparison with their typically developed (TD)... 相似文献
6.
Movahedi M Entezari N Pourpak Z Mamishi S Chavoshzadeh Z Gharagozlou M Mir-Saeeid-Ghazi B Fazlollahi MR Zandieh F Bemanian MH Farhoudi A Aghamohammadi A 《Journal of clinical immunology》2007,27(3):302-307
Leukocyte adhesion deficiency type I (LAD I) is a rare, inherited, autosomal recessive, immunodeficiency disease caused by
the combined loss of expression on the surface of leukocytes of the leukocyte integrins. We describe the clinical and laboratory
findings for 15 patients with LAD I.
The range of patients’ ages was from 10 month to 14 years (median 4 years) and 93.3% of their parents had consanguineous marriages.
The most commonly occurred manifestations were: recurrent infections (93.3%), poor wound healing (86%), oral ulcers (86%),
and skin abscesses (80%). The most specific laboratory findings were defect in CD18 in all of 15 patients.
The most common symptoms in these patients are poor wound healing and oral ulcer, so, the clinical physicians should pay special
attention to these symptoms. Furthermore, because of considerable rate of consanguineous marriages in parents of LAD patients,
we suggested more genetic studies on this disease and genetic consultation for these families.
An erratum to this article can be found at 相似文献
7.
Synthesis,evaluation, and molecular docking studies of aryl urea‐triazole‐based derivatives as anti‐urease agents 下载免费PDF全文
Setareh Moghimi Fereshteh Goli‐Garmroodi Maryam Allahyari‐Devin Hedieh Pilali Malihe Hassanzadeh Shabnam Mahernia Mohammad Mahdavi Loghman Firoozpour Massoud Amanlou Alireza Foroumadi 《Archiv der Pharmazie》2018,351(7)
8.
Azam TOFIGHI NAEEM Shima MAHMOUDI Farah SABOUI Homa HAJJARAN Babak POURAKBARI Mehdi MOHEBALI Mohammad Reza ZARKESH Setareh MAMISHI 《Iranian Journal of Parasitology》2014,9(1):1-5
Background
Visceral leishmaniasis (VL) is one of the most important parasitic diseases endemic in northwestern and southern areas of Iran. The aim of the present study was to review the records of children hospitalized with VL in order to characterize the clinical features of children as well as laboratory finding in Children Medical Center Hospital, Tehran, Iran.Methods
The medical records of all children with a final diagnosis of VL were reviewed from 2004 to 2011. Demographic, clinical information, laboratory finding and treatment were considered.Results
A total number of 34 children with confirmed VL through 2004-2011 were included in the study. The most prevalent sign and symptoms were fever (97.1%), pallor and weakness (97.1%), appetite loss (61.8%), splenomegaly (97.1%) and hepatomegaly (88.2%). The most frequent laboratory abnormalities were hematological including anemia (97.1%), thrombocytopenia (91.2%) and leukopenia (67.6%). Direct agglutination test (DAT) was performed in 23 cases and all of them showed anti-Leishmania antibodies with titers of ≥ 1: 3200. In addition, 90% of patients had positive rK39 results. Identification of Leishmania in the aspirates of the bone marrow was found in 83.3% of patients.Conclusion
Regional surveillance system in order to monitoring of leishmaniasis trends as well as detection of new emerging foci is recommended. 相似文献9.
Tabatabaie P Aghamohammadi A Mamishi S Isaeian A Heidari G Abdollahzade S Pirouzi P Rezaei N Heidarnazhad H Mirsaeid Ghazi B Yeganeh M Cheraghi T Abolhasani H Saghafi S Alizadeh H Anaraki MR 《Iranian journal of allergy, asthma, and immunology》2008,7(2):69-77
Bronchiectasis is a chronic debilitating condition characterized by abnormal dilated thick-walled bronchi. To investigate humoral immune function in bronchiectatic patients, this study was performed. Forty patients with established diagnosis of bronchiectasis, who were referred from two tertiary care pulmonology centers in Tehran, were investigated in this study. Immunoglobulin isotypes concentrations and IgG-subclasses were measured by nephelometry and enzyme-linked immunosorbent assay (ELISA) methods, respectively. All patients received unconjugated pneumococcal vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using the ELISA method. Fifteen (37.5%) out of 40 patients were diagnosed to have defects in antibody mediated immunity including 5 (12.5%) patients with immunoglobulin class deficiency (2 with common variable immunodeficiency and 3 with IgA deficiency), 3 (7.5%) with IgG subclass deficiency and 7 (17.5%) patients had Specific antibody deficiency (SAD) against polysaccharide antigen despite normal levels of serum immunoglobulins and IgG subclasses. Our study along with several other studies confirmed that all patients with bronchiectasis should undergo thorough immunological evaluation in order to identify the presence of the underlying immunologic defect. This evaluation should include serum immunoglobulins, IgG subclasses concentrations and also determination of serum antibodies against pneumococcal antigens. Early diagnosis and appropriate treatment will prevent the subsequent complications and improve quality of life of affected individuals. 相似文献