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排序方式: 共有136条查询结果,搜索用时 31 毫秒
1.
本研究旨在确定含丙醇护手霜的润肤剂对皮肤干燥和红斑的作用。35例受试者参与该前瞻性、随机、对照、双盲试验,其中约半数具有遗传过敏体质(改进的Erlanger遗传过敏体质评分≥8)。应用两种含丙醇基质的制剂进行反复开放敷贴试验,其中一种含混和润肤剂(0.81%,w/w)。每一制剂两等分各为0.7ml,随机分配给所有受试者后涂至肘窝皮肤,2次/d,持续两周以上。在每次用药前和最后一次用药3d后,根据标准评分,通过视觉检测评估治疗部位的红斑和干燥情况。所有评价时点的总分作为原始参数。 相似文献
2.
Four-dimensional (4D) PET/CT imaging of the thorax 总被引:15,自引:0,他引:15
Nehmeh SA Erdi YE Pan T Pevsner A Rosenzweig KE Yorke E Mageras GS Schoder H Vernon P Squire O Mostafavi H Larson SM Humm JL 《Medical physics》2004,31(12):3179-3186
We have reported in our previous studies on the methodology, and feasibility of 4D-PET (Gated PET) acquisition, to reduce respiratory motion artifact in PET imaging of the thorax. In this study, we expand our investigation to address the problem of respiration motion in PET/CT imaging. The respiratory motion of four lung cancer patients were monitored by tracking external markers placed on the thorax. A 4D-CT acquisition was performed using a "step-and-shoot" technique, in which computed tomography (CT) projection data were acquired over a complete respiratory cycle at each couch position. The period of each CT acquisition segment was time stamped with an "x-ray ON" signal, which was recorded by the tracking system. 4D-CT data were then sorted into 10 groups, according to their corresponding phase of the breathing cycle. 4D-PET data were acquired in the gated mode, where each breathing cycle was divided into ten 0.5 s bins. For both CT and PET acquisitions, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to respiratory phase. The effect of 4D acquisition on improving the co-registration of PET and CT images, reducing motion smearing, and consequently increase the quantitation of the SUV, were investigated. Also, quantitation of the tumor motions in PET, and CT, were studied and compared. 4D-PET with matching phase 4D-CTAC showed an improved accuracy in PET-CT image co-registration of up to 41%, compared to measurements from 4D-PET with clinical-CTAC. Gating PET data in correlation with respiratory motion reduced motion-induced smearing, thereby decreasing the observed tumor volume, by as much as 43%. 4D-PET lesions volumes showed a maximum deviation of 19% between clinical CT and phase- matched 4D-CT attenuation corrected PET images. In CT, 4D acquisition resulted in increasing the tumor volume in two patients by up to 79%, and decreasing it in the other two by up to 35%. Consequently, these corrections have yielded an increase in the measured SUV by up to 16% over the clinical measured SUV, and 36% over SUV's measured in 4D-PET with clinical-CT Attenuation Correction (CTAC) SUV's. Quantitation of the maximum tumor motion amplitude, using 4D-PET and 4D-CT, showed up to 30% discrepancy between the two modalities. We have shown that 4D PET/CT is clinically a feasible method, to correct for respiratory motion artifacts in PET/CT imaging of the thorax. 4D PET/CT acquisition can reduce smearing, improve the accuracy in PET-CT co-registration, and increase the measured SUV. This should result in an improved tumor assessment for patients with lung malignancies. 相似文献
3.
Percutaneous transcatheter embolization of splanchnic artery aneurysms is a minimally invasive and alternative therapy to
conventional surgical intervention. Due to a high-grade stenosis at the origin of the celiac trunk, a retrograde approach
to the celiac trunk pseudoaneurysm via the gastroduodenal artery was necessary. To prevent undesirable embolization into the
peripheral left gastric artery initial occlusion of the central portion of the left gastric artery was performed with microcoils
using a Tracker catheter. Complete occlusion of the celiac trunk itself and the short adjacent segments of the celiac artery
was achieved by using a mixture of N-butyl-2-cyanoacrylate and ethiodized oil as the embolizing agent.
Received: 22 June 1999; Revised: 7 September 1999; Accepted: 1 October 1999 相似文献
4.
Sonja Loges Gerhard Heil Melanie Bruweleit Volker Schoder Martin Butzal Uta Fischer Ursula M Gehling Gunter Schuch Dieter K Hossfeld Walter Fiedler 《Journal of clinical oncology》2005,23(6):1109-1117
PURPOSE: Bone marrow neoangiogenesis plays an important pathogenetic and possible prognostic role in acute myeloid leukemia (AML). Members of the vascular endothelial growth factor (VEGF) and angiopoietin family represent the most specific inducers of angiogenesis secreted by AML blasts. We therefore correlated expression of angiogenic factors with clinical variables. PATIENTS AND METHODS: We investigated the expression of VEGF-A, VEGF-C, angiopoietin-1 (Ang1), angiopoietin-2 (Ang2), and the receptor Tie2 by quantitative polymerase chain reaction in a cohort of 90 patients younger than 61 years with de novo AML entered into the German AML Süddeutsche H?moblastose Gruppe Hannover 95 trial. Uni- and multivariate analyses were performed using clinical and gene expression variables. RESULTS: Univariate analysis of overall survival indicated the following variables as prognostic factors: good response on a day-15 bone marrow examination after initiation of induction chemotherapy, karyotype, and high Ang2 expression. In multivariate analysis, only bad response and log Ang2 expression remained of statistical significance, with a hazard ratio of 3.51 (95% CI, 1.91 to 6.47) and 0.75 (95% CI, 0.61 to 0.91), respectively. Subgroup analysis suggested that the prognostic impact of Ang2 expression was especially evident in cohorts with low VEGF-C and Ang1 mRNA levels. CONCLUSION: These results show that expression of Ang2 represents an independent prognostic factor in AML. Additional research into interactions of angiogenic cytokines in the pathogenesis of bone marrow angiogenesis in AML is warranted. 相似文献
5.
Grahmann PR Schoder A Warzelhan J Zehender M Hasse J 《Pneumologie (Stuttgart, Germany)》2002,56(10):593-598
Ikeda has introduced flexible bronchoscopy in the seventies of the last century. Since then the over one hundred year old procedure of direct airways inspection has widely spread and enhanced the diagnostic and therapeutic means. Thus the flexible bronchoscopy has become an important part of modern medicine. The close combination of atropine as premedication with bronchoscopy is justified with the terms "cardioprotection" and reduction of mucus secretion. As there is to this date no controlled study to prove this assumption, with the start of bronchoscopy we controlled every patient with a holter-ecg for 24-hours and estimated semiquantitatively the mucus secretion during procedure by a four point scale. Consecutively 55 patients could be randomised, 25 (7 females, 18 males) in the group with and 30 (7 females, 18 males) without atropine. In the records there were no detectable significant differences between the groups with atropine (A) and without atropine (P), as well as for registered bradycardias (A: 0 vs. P: 0, minimum of heart beats A: 63.8 vs. P: 74.1 min -1) as well as for alterations of heart rhythms, e. g. SVES (A: 7.3 % vs. P: 5.5 %), VES (A: 9.0 % vs. P: 9.0 %) or a combination of SVES with VES (A: 12.7 % vs. P: 10.9 %). The same results could be seen for each single of the first twenty minutes, additionally the first and the second recorded hour and the whole registered 24 hours. Moreover the times needed to complete the bronchoscopy showed no significant difference (mean of t A: 16.8 vs. P: 15.6 min, t-minimum 10 vs. 10 min, t-maximum A: 30 vs. P: 35 min). The same absence of differences was seen in estimated endobronchial mucus secretion (mean A: 1.88 vs. P: 2.0). According to these results of our studied group, there are no reasons, why a premedication with atropine in flexible bronchoscopy in local anaesthesia should be used. Even without the administration of atropine, flexible bronchoscopy could be performed as a safe and sophisticated method in direction of not inducing relevant arrhythmia, with low impact on patients. 相似文献
6.
Johannes Lammer Thomas Zeller Klaus A. Hausegger Philipp J. Schaefer Manfred Gschwendtner Stefan Mueller-Huelsbeck Thomas Rand Martin Funovics Florian Wolf Aljoscha Rastan Michael Gschwandtner Stefan Puchner Ulrich Beschorner Robin Ristl Maria Schoder 《Cardiovascular and interventional radiology》2015,38(3):779-780
7.
Background Incidental thyroid abnormalities are increasingly detected in patients undergoing PET scans. The aim of this study was to
review our experience with the management of PET detected thyroid incidentalomas in a large single institution series.
Methods All PET scans performed from May 2003 to July 2005 were reviewed and patients with incidental thyroid abnormalities were identified.
From this group, patients that underwent further investigation were analyzed. Data relating to PET scan findings, FNA diagnoses,
operative details, and histopathology was reviewed.
Results In 8,800 patients, 16,300 PET scans were performed of whom 263 patients (2.9% of patients and 1.6% of PET scans) had findings
positive for thyroid abnormality. Thyroid malignancy was noted in 42% (24 patients) of the 57 patients that underwent FNA.
In the group of 27 patients that were subjected to operative intervention, 74% (20 patients) were noted to have a malignant
diagnosis. The final histopathology revealed primary thyroid carcinoma in all these 20 patients (19 patients with papillary
carcinoma and one patient with primary thyroid lymphoma). The factors that correlated with an increased risk of malignancy
were the presence of physical finding (p = 0.01) and focal (p < 0.01) or unilateral uptake (p < 0.01) on PET scan. The average SUV was not useful in differentiating benign (9.2) from malignant lesions (8.2, p = 0.7).
Conclusions PET detected incidental thyroid abnormalities are rare. In patients with positive PET scan findings and suspicious features,
the incidence of primary thyroid malignancy is very high. These patients warrant further investigation followed by possible
operative intervention. 相似文献
8.
9.
Arterial Embolization of Unresectable Hepatocellular Carcinoma with Use of Microspheres, Lipiodol, and Cyanoacrylate 总被引:3,自引:0,他引:3
Rand T Loewe C Schoder M Schmook MT Peck-Radosavljevic M Kettenbach J Wolf F Schneider B Lammer J 《Cardiovascular and interventional radiology》2005,28(3):313-318
We performed a retrospective analysis of 46 patients with histologically confirmed hepatocellular carcinoma (HCC) who were treated with transarterial embolization (TAE) of the hepatic arteries. To induce permanent embolization, microspheres (Embosphere; 100 to 700) and a mixture of ethiodized oil (Lipiodol Ultrafluide) with cyanoacrylate (Glubran) was injected. A total of 106 TAE procedures were performed. Cumulative survival rates were calculated. No patient died during embolization or within the first 24 hours. Severe procedure-related complications were observed in 2 patients. At the time of analysis, 38 of 46 patients were alive. The 180-, 360-, 520-, and 700-day cumulative survival rates for the total study population were 80.6%, 70.7%, 70.7%, and 47.1%, respectively, with a median survival of 666 days. TAE with the use of microspheres and Lipiodol and cyanoacrylate for unresectable HCC is a feasible treatment modality. Bland embolization with the use of microspheres can be used in patients for whom chemoembolization is not desired. 相似文献
10.
Czerny M Zimpfer D Fleck T Hofmann W Schoder M Cejna M Stampfl P Lammer J Wolner E Grabenwoger M 《The Annals of thoracic surgery》2004,78(4):1256-1260