全文获取类型
收费全文 | 653篇 |
免费 | 67篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 24篇 |
妇产科学 | 8篇 |
基础医学 | 77篇 |
口腔科学 | 17篇 |
临床医学 | 106篇 |
内科学 | 130篇 |
皮肤病学 | 2篇 |
神经病学 | 32篇 |
特种医学 | 11篇 |
外科学 | 94篇 |
综合类 | 18篇 |
一般理论 | 10篇 |
预防医学 | 90篇 |
眼科学 | 15篇 |
药学 | 51篇 |
肿瘤学 | 36篇 |
出版年
2022年 | 9篇 |
2021年 | 13篇 |
2020年 | 8篇 |
2019年 | 20篇 |
2018年 | 9篇 |
2017年 | 7篇 |
2016年 | 13篇 |
2015年 | 14篇 |
2014年 | 17篇 |
2013年 | 22篇 |
2012年 | 20篇 |
2011年 | 30篇 |
2010年 | 15篇 |
2009年 | 11篇 |
2008年 | 17篇 |
2007年 | 16篇 |
2006年 | 22篇 |
2005年 | 15篇 |
2004年 | 18篇 |
2003年 | 24篇 |
2002年 | 15篇 |
2001年 | 27篇 |
2000年 | 21篇 |
1999年 | 24篇 |
1998年 | 13篇 |
1997年 | 6篇 |
1996年 | 7篇 |
1992年 | 18篇 |
1991年 | 15篇 |
1990年 | 17篇 |
1989年 | 14篇 |
1988年 | 9篇 |
1987年 | 15篇 |
1986年 | 12篇 |
1985年 | 15篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 10篇 |
1979年 | 22篇 |
1978年 | 8篇 |
1975年 | 5篇 |
1974年 | 10篇 |
1973年 | 11篇 |
1972年 | 11篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1968年 | 6篇 |
1966年 | 8篇 |
排序方式: 共有726条查询结果,搜索用时 31 毫秒
1.
2.
Radiographic appearances in lumbar disc prolapse 总被引:1,自引:0,他引:1
J G MacLean J K Tucker J B Latham 《The Journal of bone and joint surgery. British volume》1990,72(5):917-920
The pre-operative lumbar spine radiographs of 200 consecutive patients who had undergone discectomy for prolapsed intervertebral disc were reviewed. Prolapse was recognized as bulging or sequestration of the disc with consequent root compromise. Measurement of the lumbar level of the interiliac line was shown to correlate with the level of disc prolapse and the incidence of transitional vertebrae at the lumbosacral junction was significantly higher than normal. A pathological value for the lumbosacral angle could not be identified. 相似文献
3.
Louise Bergeron Gloria I. Perez Glen Macdonald Lianfa Shi Yi Sun Andrea Jurisicova Sue Varmuza Keith E. Latham Jodi A. Flaws Jessica C.M. Salter Hideaki Hara Michael A. Moskowitz En Li Arnold Greenberg Jonathan L. Tilly Junying Yuan 《Genes & development》1998,12(9):1304-1314
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of proteases are essential intracellular death effectors. Herein, we generated caspase-2-deficient mice to evaluate the requirement for this enzyme in various paradigms of apoptosis. Excess numbers of germ cells were endowed in ovaries of mutant mice and the oocytes were found to be resistant to cell death following exposure to chemotherapeutic drugs. Apoptosis mediated by granzyme B and perforin was defective in caspase-2-deficient B lymphoblasts. In contrast, cell death of motor neurons during development was accelerated in caspase-2-deficient mice. In addition, caspase-2-deficient sympathetic neurons underwent apoptosis more effectively than wild-type neurons when deprived of NGF. Thus, caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development. 相似文献
4.
A. W. Smith T. G. Akers A. B. Latham D. E. Skilling H. L. Bray 《Archives of virology》1979,61(3):255-259
Summary A new serotype of calicivirus, designated as San Miguel sea lion virus type 6 (SMSV-6), was isolated from vesicular lesions on the flipper of a California sea lion pup. Serologic studies show that SMSV-6 neutralizing antibodies (SN) occur frequently among California sea lions and occasionally among northern fur seals. Feral swine, 1- to 6-week elephant seal pups and grey whales tested negative for SMSV-6 antibody. 相似文献
5.
Sarah L. Nolin Anne Glicksman Nicole Tortora Emily Allen James Macpherson Montserrat Mila Angela M. Vianna‐Morgante Stephanie L. Sherman Carl Dobkin Gary J. Latham Andrew G. Hadd 《American journal of medical genetics. Part A》2019,179(7):1148-1156
Instability of the FMR1 repeat, commonly observed in transmissions of premutation alleles (55–200 repeats), is influenced by the size of the repeat, its internal structure and the sex of the transmitting parent. We assessed these three factors in unstable transmissions of 14/3,335 normal (~5 to 44 repeats), 54/293 intermediate (45–54 repeats), and 1561/1,880 premutation alleles. While most unstable transmissions led to expansions, contractions to smaller repeats were observed in all size classes. For normal alleles, instability was more frequent in paternal transmissions and in alleles with long 3′ uninterrupted repeat lengths. For premutation alleles, contractions also occurred more often in paternal than maternal transmissions and the frequency of paternal contractions increased linearly with repeat size. All paternal premutation allele contractions were transmitted as premutation alleles, but maternal premutation allele contractions were transmitted as premutation, intermediate, or normal alleles. The eight losses of AGG interruptions in the FMR1 repeat occurred exclusively in contractions of maternal premutation alleles. We propose a refined model of FMR1 repeat progression from normal to premutation size and suggest that most normal alleles without AGG interruptions are derived from contractions of maternal premutation alleles. 相似文献
6.
Pieter Sipkema Ricky D. Latham Nicolaas Westerhof Bernard J. Rubal David M. Slife 《Annals of biomedical engineering》1990,18(5):491-503
A setup consisting of a high-performance hydraulic pump connected to the ascending part of an isolated aorta, including all
major distal branches, each loaded with calibrated artificial resistors, was developed. The system was used to study total
aortic compliance of the baboon as a function of mean aortic pressure (n=5). The aorta loaded with the resistors was mounted
in a custom-designed sink table, such that it was submersed in physiological saline maintained at 37°C. Mean distending pressure
in the entire aortic compliance from pressure and flow waves generated by the pump. Total aortic compliance as a function
of mean pressure was fitted with a logarithmic function: Ln (Compliance)=A+B * P. The value of A(±SE) was: 1.565±0.319 and
B: −0.020±0.003 (P<0.001). The results were compared with previously published results (also using the same three-element
Windkessel fit) obtained in three of the same animalsin vivo. Thein vivo data were A: 1.095±0.235 and B: −0.019±0.003.In vitro data had a significantly higher value of A thanin vivo (P=0.017), implying a significantly higher aortic compliancein vitro thanin vivo.
Occlusion of the proximal descending aorta was performed at a low distending pressure (55 mm Hg) to determine the proximal
complicance. It was found (n=4) that 46±11% (SD) of the total arterial compliance is to be attributed to the ascending and
proximal descending aorta.
This work was supported in part by Grant RG 86/0066 from the scientific affairs division of Nato. 相似文献
7.
8.
Medical professionalism in society 总被引:11,自引:0,他引:11
Wynia MK Latham SR Kao AC Berg JW Emanuel LL 《The New England journal of medicine》1999,341(21):1612-1616
9.
Flanagan L 《Obesity surgery》1996,6(1):38-43
Background: The cottage cheese test was developed in an attempt to find a simple way to measure functional pouch volume and
to better understand the fate of the tiny proximal pouch following the gastric bypass procedure. Methods: Our patients were
asked to eat cottage cheese in a structured fashion before their return visits from 3 months to 2 years postoperatively. Results:
We found there was a step-wise progression of increase in functional pouch volume with statistical significance between each
time interval. Also, we compared the patients' excess weight loss at 1, 2, and 3 years postoperatively to their pouch size
at 1 year postoperatively. Although there is a wide range (2.5-9.0 oz) of pouch sizes at 1 year, there is no significant difference
in excess weight loss between the smaller and larger pouches. Conclusions: The pouches enlarge by the orderly process of hyperplasia.
Within the 2.5-9 oz volume variation, the pouch volume alone is not a predictor of weight loss. Rather, how the patient uses
the pouch/tool, in addition to the other behavior modifications, determines the degree of weight loss. This data strongly
suggests that the surgeon's understanding of and teaching of the optimal use of the pouch/tool may be more important than
previously thought. 相似文献
10.
Zarate E Latham P White PF Bossard R Morse L Douning LK Shi C Chi L 《Anesthesia and analgesia》2000,91(2):283-287
The purpose of this cardiac fast-track study was to evaluate the use of remifentanil (R) combined with intrathecal (IT) morphine as an alternative to sufentanil (S) during desflurane anesthesia with respect to postoperative pain control. Prior to entering the operating room, patients in the R group (n = 20) received morphine, 8 microg/kg IT. Anesthesia was induced using a standardized anesthetic technique in all patients. In the R group, anesthesia was maintained with R, 0.1 microg. kg(-1). min(-1) in combination with desflurane 3-10%. In the S group (n = 20), patients received S 0.3 microg. kg(-1). h(-1) and desflurane 3-10%. There were no differences between the two groups with respect to time from arrival in the intensive care unit to tracheal extubation (5.1 +/- 4.3 h vs 5.8 +/- 6.7 h for R and S groups, respectively). After extubation, patients in the R group had significantly lower visual analog pain scores, reduced patient-controlled analgesic requirements, and greater satisfaction with their perioperative pain management, compared with patients in the S group. We conclude that R combined with IT morphine provided superior pain control after cardiac surgery compared with a S-based general anesthetic technique. Implications: As part of a cardiac fast-tracking program involving desflurane anesthesia, the use of intrathecal morphine in combination with a remifentanil infusion provided improved postoperative pain control, compared with IV sufentanil alone. 相似文献