回盲部与肠易激综合征

目前通常认为肠易激综合征(IBS)为一种结肠动力性疾病。其含义正在延伸,而且许多文献报道IBS病人的结肠、小肠、食管、胆囊、膀胱均发现运动异常。本文重点集中在回盲部或回结肠连接处(ICJ)。     

2005年病毒性肝炎的新进展（下）

丙型肝炎 几篇章报道了感染HCV基因2／3型患短期治疗的可行性、难治患的治疗措施及新型疗法的相关资料。     

Airway management and air medical transport

A 5-year retrospective review of airway management by flight nurses was conducted to evaluate airway care and to determine the frequency of surgical cricothyrotomy. Intubation was attempted in 51% of patients, with a success rate of 80%. Oral intubations were attempted in the remaining patients and in those patients in whom initial attempts at nasal intubation failed, with a success rate of 81%. The success rate for intubations was 72% in 1985, 95 % in 1986, 92% in 1987, 97% in 1988, and 76% in 1989. Overall, 87% of patients were successfully intubated and surgical cricothyrotomy was required in only one patient. A greater success rate was achieved when intubations were performed before takeoff than during flight.     

Retinal slip during active head motion and stimulus motion

Gaze control in various conditions is important, since retinal slip deteriorates the perception of 3-D shape of visual stimuli. Several studies have shown that visual perception of 3-D shape is better for actively moving observers than for passive observers watching a moving object. However, it is not clear to what extent the improved percept of 3-D shape for active observers has to be attributed to corollary discharges to higher visual centers or whether the improved percept might be due to improved gaze stabilization during active head movements. The aim of this study was to measure binocular eye movements and to make a quantitative comparison of retinal slip for subjects instructed to fixate a visual stimulus in an active condition (subject makes an active head movement, object is stationary) and in a passive condition (the stimulus moves, the subject is stationary) for various movement frequencies, viewing distances, and stimulus diameters. Retinal slip remains below the acuity threshold of about 4 deg/s in active conditions, except for the highest frequency tested in this study (1.5 Hz) for nearby targets (0.25 cm). Retinal slip exceeds this threshold for most passive conditions. These results suggest that the enhanced performance in the visual perception of 3-D shape during active head movements can, at least partly, be explained by better fixation by actively moving observers.     

Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression

Yellow fever (YF) is a zoonotic infection with more than 200,000 cases reported annually. Relatively little is known about YF pathogenesis in humans. In this study, we demonstrate that human vascular endothelial cells are susceptible to infection with wild-type and vaccine strains of the YFV and that these infections lead to a differential cellular response to infection. The infection of endothelial cells with either virus resulted in a significant induction of interferon-inducible genes p 78 and Cig 5 while wild-type virus induced a much more pronounced IL 6 and Bc l2 response than did the vaccine strain. Both viruses induced RANTES gene expression, but only the wild-type virus had corresponding increases in RANTES protein expression. The results demonstrate that the wild-type and vaccine strains of YFV elicit significantly different responses to infection in endothelial cells, despite being nearly identical genetically. These differences may account for the attenuated phenotype of the YFV vaccine strain, though the mechanism remains unclear. These data also point to a role for vascular endothelial cells in YF hemorrhagic fever and also suggest that IL 6 may play a role in increased viral pathogenesis, perhaps by influencing coagulation via release of coagulation co-factors such as fibrin or fibrinogen.