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Wan-zhang Qin 《中国结合医学杂志》2002,8(4):248-250
Psoriasisisacommon,easytorecur,chronicin flammatorydiseaseoftheskin.Theexactcauseofitisstillunknown,andtherearemanyhypothesesforit,suchasheredity,infection,metabolicdisorder,en docrineinfluence,neuro -psychicfactors,immuno logicdisorder.Treatmentofpsor… 相似文献
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一、一般资料1.性别、年龄:男30例,女18例,年龄最大71岁,最小18岁,其中30岁以下10例(20.8%),50岁以下24例(50%),60岁以下9例(18.8%),61岁以上5例(10.4 %)。2.病程、职业:1年以内14例,1~5年22例,5年以上12例,最长11年,最短4个月。其中工人16例,干部13例,农民14例,其它5例。3.肠镜,钡灌肠、化验室检查:48例中经纤维结肠镜检查34例,乙状结肠镜检查8例,钡灌肠检查6例,均诊断为慢性结肠炎。肠粘膜充血水肿42例,糜烂12例,溃疡5例,出血 相似文献
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目的:探讨提高嗜铬细胞瘤患者围手术期安全性的措施。方法:对15例嗜铬细胞瘤患者、术前采用选择性α1受体阻滞剂多沙唑嗪控释片(可多华)控制高血压;11例患者采用3D DCEMRA进行肿瘤定位;术中均采用联合高容量血液稀释(AHH)和术中患者自体血回输纠正血容量。结果:除1例持续性高血压患者需联合钙离子拮抗剂和ACEI药物降压外.其余患者血压控制均为满意;根据3D DCEMRA定位选择手术径路者均顺利完成手术;AHH联合术中自体血回输使14例患者避免了异体输血。结论:本文围手术期处理改进.可多华可明显减少药物的不良反应;采用3D DCEMRA进行肿瘤定位,可增加手术安全性;AHH联合术中自体血回输可减少医疗成本和异体输血,以及由此而引起的并发症。 相似文献
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原发性色素性结节状肾上腺皮质病(附4例报告) 总被引:1,自引:0,他引:1
目的:探讨原发性色素性结节状肾上腺皮质病(PPNAD)的临床表现和诊断治疗方法。方法:总结4例PPNAD的临床资料,4例均有库欣综合征的临床表现,内分泌检查结果提示为功能自主性肾上腺皮质肿瘤,但影像学检查并未发现肾上腺肿瘤。结果:4例患者均行单侧肾上腺全切除术,手术标本均表现为肾上腺大小正常或轻度增大,外表和切面上见黑色或深褐色小结节,结节间皮质萎缩,光镜下见组成结节的细胞体积大,脑质嗜伊红染色、颗粒状,部分细胞脑质中的颗粒状色素颗粒具脂褐质染色特征。结论:PPNAD在青少年中是一种引起库欣综合征的罕见病因,双侧肾上腺切除术是治愈本病的方法。 相似文献
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Influence of mild hypothermia on vascular endothelial growth factor and infarct volume in brain tissues after cerebral ischemia in rats 总被引:1,自引:0,他引:1
BACKGROUND: It has been demonstrated that mild hypothermia has obvious protective effect on both whole and local cerebral ischemia. However, the definite mechanism is still unclear for the brain protection of mild hypothermia on cerebral edema, inhibiting inflammatory reaction, stabilizing blood brain barrier, etc.
OBJECTIVE: To investigate the effect of mild hypothermia on the expression of vascular endothelial growth factor and the infarct volume after cerebral ischemia in rats, and analyze the brain protective mechanism of mild hypothermia.
DESIGN: A randomized grouping and controlled animal trial.
SETTING: Department of Neurology, People's Hospital of Yunyang Medical College.
MATERIALS: Twenty adult male SD rats of clean degree, weighing (250±30) g, were provided by the animal experimental center, School of Medicine, Wuhan University. The kits for SP immunohistochemistry were purchased from Beijing Zhongshan Golden Bridge Biotechnology Co., Ltd.
METHODS: The experiments were carried out in the laboratory of Department of Neurology, Renmen Hospital of Wuhan University from May to July 2005. ① The 20 rats were divided randomly into normal temperature group (n =10) and mild hypothermia group (n =10). Models of permanent middle cerebral artery occlusion were established with modified nylon suture embolization. The rats were assessed with the Longa standards: 0 point for without nerve dysfunction; 1 for mild neurological deficit (fore claws could no extend completely); 2 for moderate neurological deficit (circling towards the affected side); 3 for severe neurological deficit (tilting towards the affected side); 4 for coma and unconscious; 1-3 points represented that models were successfully established. The rats of the normal temperature group were fed at room temperature, and those in the mild hypothermia group were induced by hypothermia from 2 hours postoperatively, and the rectal temperature was kept at 34-35 ℃ for 72 hours. ② Measurement of infarct volume: All the rats were anesthetized by intraperitoneal injection overdose sodium pentobarbital 7 days postoperatively, and then the heads were cut down to harvest brain. The brain tissues were placed into -20 ℃ refrigerator for 20 minutes, coronal sections of 2 mm were prepared. The infarct sites were not stained, whereas normal brain tissues were stained as red. The infarct volumes were calculated by using MPLAS-500 multimedia color pathological image&&word analytical system. ③ Counting positive cells of vascular endothelial growth factor protein: The brains were harvested by cutting heads, then coronal sections of 2 mm were prepared. Routine dehydration, hyalinization, wax immersion and embedding were performed, then the detected with SP immunohistochemistry, the kits were purchased from Beijing Zhongshan Golden Bridge Biotechnology Co., Ltd. The cells whose cytoplasm was yellow-brown were positive ones, a single sample as a unit, peri-ischemic site and ischemic core were selected, and the corresponding sites in controlateral hemisphere were taken as controls. Five visual fields were selected from each site to be observed under microscope, the cells were counted, and the average number of positive cells was calculated in each group. The numbers of positive cells were determined with the image analytical apparatus.
MAIN OUTCOME MEASURES: Number of the positive cells of vascular endothelial growth factor protein; Infarct volume of rat brain tissue.
RESULTS: All the 20 rats were involved in the analysis of results. ① Number of positive cells of vascular endothelial growth factor protein in brain tissue: It was obviously lower in the mild hypothermia group than in the normal temperature group [(24.02±5.05), (36.07±2.69) cells/high power visual field, P < 0.01]. ② Comparison of infarct volume of brain tissue: After MCAO, it was obviously smaller in the mild hypothermia group than in the normal temperature group [(153.25±23.14), (253.45±36.21) mm3, P < 0.01].
CONCLUSION: Mild hypothermia can inhibit the expression of vascular endothelial growth factor and decrease the volume of cerebral infarction. The inhibition of mild hypothermia on the expression of vascular endothelial growth factor may be one of the brain protective mechanisms. 相似文献