全文获取类型
收费全文 | 693篇 |
免费 | 50篇 |
国内免费 | 13篇 |
专业分类
儿科学 | 17篇 |
妇产科学 | 9篇 |
基础医学 | 144篇 |
口腔科学 | 37篇 |
临床医学 | 53篇 |
内科学 | 76篇 |
皮肤病学 | 48篇 |
神经病学 | 45篇 |
特种医学 | 110篇 |
外科学 | 22篇 |
综合类 | 10篇 |
预防医学 | 57篇 |
眼科学 | 16篇 |
药学 | 51篇 |
肿瘤学 | 61篇 |
出版年
2021年 | 6篇 |
2019年 | 11篇 |
2018年 | 5篇 |
2017年 | 10篇 |
2016年 | 12篇 |
2015年 | 9篇 |
2014年 | 19篇 |
2013年 | 17篇 |
2012年 | 21篇 |
2011年 | 31篇 |
2010年 | 18篇 |
2009年 | 14篇 |
2008年 | 31篇 |
2007年 | 42篇 |
2006年 | 27篇 |
2005年 | 25篇 |
2004年 | 26篇 |
2003年 | 17篇 |
2002年 | 16篇 |
2001年 | 21篇 |
2000年 | 15篇 |
1999年 | 19篇 |
1998年 | 31篇 |
1997年 | 20篇 |
1996年 | 18篇 |
1995年 | 17篇 |
1994年 | 10篇 |
1993年 | 13篇 |
1992年 | 14篇 |
1991年 | 18篇 |
1990年 | 13篇 |
1989年 | 16篇 |
1988年 | 19篇 |
1987年 | 14篇 |
1986年 | 12篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1979年 | 9篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 7篇 |
1972年 | 8篇 |
1971年 | 3篇 |
1966年 | 4篇 |
排序方式: 共有756条查询结果,搜索用时 15 毫秒
1.
Hans D de Boer Jan van Egmond Jacques J Driessen Leo HD Booij 《Neuropsychiatric Disease and Treatment》2007,3(5):539-544
Steroidal neuromuscular blocking agents (NMBAs), such as rocuronium, are widely used in clinical anesthesia and emergency medicine to facilitate endotracheal intubation and artificial ventilation and to allow surgical access to body cavities. Reversal of neuromuscular blockade is important for the acceleration of patient recovery and prevention of postoperative residual neuromuscular blockade and reduces the incidence of severe morbidity and mortality associated with anesthesia management. Sugammadex is the first selective relaxant binding agent (SRBA) and has been designed to reverse the steroidal neuromuscular blocking drug rocuronium. Encapsulation of the rocuronium molecule by sugammadex results in a rapid decrease in free rocuronium in the plasma and subsequently at the nicotinic receptor at the motor endplate. After encapsulation, rocuronium is not available to bind to the nicotinic receptor in the neuromuscular junction. This promotes the liberation of acetylcholine receptors, and muscle activity reappears. This new concept of reversal of neuromuscular block induced by rocuronium (or vecuronium) led to impressive results in animal and phase 1 and 2 studies. Sugammadex is currently in phase 3 clinical studies and may be commercially available by 2008. 相似文献
2.
The high incidence and profile of ras gene mutations reported in spontaneous and chemically induced liver tumours of the B6C3F1 mouse provides a potential means of determining in vivo genotoxicity and its relevance to carcinogenicity. We analysed spontaneous and chemically induced [with 4-amino-biphenyl (ABP), 2-acetylaminofluorene (AAF) and diethylnitrosamine (DEN)] hepatocellular tumours of the C57Bl/10J mouse for H-ras, K-ras and N-ras gene mutations to see if mutational analysis of the ras genes could be useful for such a determination in this strain. Regions of DNA spanning codons 12, 13 and 61 of the ras genes were amplified from formalin fixed liver tumour sections using the polymerase chain reaction. Mutations were detected using allele specific oligonucleotide probing and confirmed by sequencing. We have found that there are few ras mutations in either spontaneous or chemically induced liver tumours in the C57Bl/10J mouse. Out of 25 spontaneous tumours two contained an A to T transversion and one contained an A to G transition in base 2 of H-ras codon 61 and two contained a G to A transition in base 2 of K-ras codon 13 (the K-ras mutations were only faintly detectable and may be present in a subpopulation of the tumour cells). In the case of the 18 ABP induced tumours one contained a C to A transversion in base 1 of H-ras codon 61, and one contained an A to T transversion in base 2 of H-ras codon 61 and one contained a G to C transversion in base 1 of K-ras codon 13. One C to A transversion in base 1 of H-ras codon 61 was detected out of eight AAF induced tumours. Of the 25 DEN induced tumours, one contained an A to G transition and one contained an A to C transversion in base 2 of H-ras codon 61. The data indicate that at least in hepatocellular tumours of the C57Bl/10J strain and using chronic dosing regimes the ras genes do not represent markers for in vivo genotoxic activity. 相似文献
3.
In vitro and in vivo precipitation of iodinated contrast agents when ioxaglate and papaverine are given together has been reported. To verify these reports and to investigate other medications not previously tested, the authors analyzed mixtures of contrast agents and medications in vitro with a light spectrophotometer and observed them for visible precipitates for up to 120 minutes. Previously reported incompatibilities between ionic or low-osmolality contrast media and medications were verified, and several new incompatibilities were discovered. No incompatibilities were found when the drugs tested were mixed with the new nonionic contrast media. 相似文献
4.
5.
6.
7.
8.
Donald F. Orton M.D. Dennis F. Strauss M.D. Michael Hummel M.D. Dale Orton M.D. F.A.C.E.P. 《Emergency radiology》1998,5(3):173-175
The intraperitoneal mass most commonly encountered after blunt abdominal truama is a hematoma. However, one must also consider
unusual bulky tumors that can have imaging characteristics similar to those of hematoma. The most typical of these neoplasms
is lymphoma, but a desmoplastic small cell tumor also may be observed. The presentation and imaging findings of a desmoplastic
small tumor are described. 相似文献
9.
Parental and professional responses to questionnaires evaluating a paediatric disability service are reported and the viability of auditing structural, process, and outcome aspects of clinical practice are discussed. Expectations of waiting time to first appointment (met for only 52% of consumers) illustrate structural issues. Process issues are reflected in consumer reactions to outreach work (for example, 94% of parents and 84% of professionals found this supportive). Outcome measures such as consumer satisfaction with the service (76% of consumers reported being 'very satisfied' and 20% 'fairly satisfied') suggest that service aims are being met. Good concurrence of service aims with consumer needs is indicated by parental reasons for referral (for example, 75% for diagnostic help, 73% for a better understanding of the disorder, 88% for practical help), referrers' reasons (for example, 55% for a second diagnostic opinion, 45% due to lack of local expertise), and reports from most other professionals involved with the case that a similar service was not provided locally. 相似文献
10.
C G Orton 《International journal of radiation oncology, biology, physics》1988,14(3):557-560
Conventional dose-effect relationships, such as those based upon the NSD or linear-quadratic concepts, do not account for dose inhomogeneities. Only a single "dose" value can be used in these equations and this can give rise to significant errors in the estimation of the "tolerance" dose in situations where dose distributions are inhomogeneous. This paper presents a method of "integrating" the biologically effective dose over the entire volume of each organ or tissue irradiated. Integral forms of the variable-exponent TDF and linear quadratic factor (LQF) models (ITDF and ILQF, respectively) can be used to determine whether or not any organ or tissue in an irradiated volume has exceeded tolerance, regardless of dose distribution non-uniformity. Several examples are given with comparisons to solutions obtained by conventional dose-effect models. 相似文献