全文获取类型
收费全文 | 1665篇 |
免费 | 192篇 |
国内免费 | 19篇 |
专业分类
儿科学 | 91篇 |
妇产科学 | 7篇 |
基础医学 | 297篇 |
口腔科学 | 66篇 |
临床医学 | 175篇 |
内科学 | 295篇 |
皮肤病学 | 106篇 |
神经病学 | 42篇 |
特种医学 | 245篇 |
外科学 | 115篇 |
综合类 | 66篇 |
一般理论 | 1篇 |
预防医学 | 189篇 |
眼科学 | 14篇 |
药学 | 69篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 96篇 |
出版年
2021年 | 14篇 |
2020年 | 14篇 |
2019年 | 15篇 |
2018年 | 26篇 |
2017年 | 14篇 |
2016年 | 15篇 |
2015年 | 36篇 |
2014年 | 36篇 |
2013年 | 58篇 |
2012年 | 52篇 |
2011年 | 42篇 |
2010年 | 70篇 |
2009年 | 61篇 |
2008年 | 52篇 |
2007年 | 63篇 |
2006年 | 48篇 |
2005年 | 51篇 |
2004年 | 50篇 |
2003年 | 49篇 |
2002年 | 44篇 |
2001年 | 45篇 |
2000年 | 28篇 |
1999年 | 56篇 |
1998年 | 97篇 |
1997年 | 88篇 |
1996年 | 70篇 |
1995年 | 63篇 |
1994年 | 41篇 |
1993年 | 53篇 |
1992年 | 25篇 |
1991年 | 40篇 |
1990年 | 21篇 |
1989年 | 50篇 |
1988年 | 50篇 |
1987年 | 34篇 |
1986年 | 30篇 |
1985年 | 29篇 |
1984年 | 17篇 |
1983年 | 19篇 |
1982年 | 21篇 |
1981年 | 27篇 |
1980年 | 25篇 |
1979年 | 11篇 |
1978年 | 27篇 |
1977年 | 20篇 |
1976年 | 15篇 |
1975年 | 14篇 |
1974年 | 5篇 |
1966年 | 4篇 |
1965年 | 3篇 |
排序方式: 共有1876条查询结果,搜索用时 15 毫秒
1.
Veronique Braud E. Yvonne Jones Andrew McMichael 《European journal of immunology》1997,27(5):1164-1169
Human histocompatibility leukocyte antigen E (HLA-E) and mouse major histocompatibility complex (MHC) class Ib antigen, Qa-1, share the same substitutions at two normally conserved positions 143 and 147, which are likely to affect binding of the C terminus of peptides. Qa-1 is able to bind a peptide derived from the leader sequence of H-2 D and H-2 L molecules. We developed a peptide binding assay in vitro to compare the binding specificity of HLA-E with the mouse MHC class Ib molecule Qa-1. We demonstrate that HLA-E binds, although poorly, the peptide which binds to Qa-1 and that it also binds nonamer signal sequence-derived peptides from human MHC class I molecules. Using alanine and glycine substitutions, we could define primary anchor residues at positions 2 and 9 and secondary anchor residues at position 7 and possibly 3. 相似文献
2.
Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro 总被引:1,自引:0,他引:1
Marjana Tomic-Canic PhD ; Stephen W. Mamber PhD ; Olivera Stojadinovic MD ; Brian Lee MSc ; Nadezda Radoja PhD ; John McMichael PhD 《Wound repair and regeneration》2007,15(1):71-79
ML-05, a modified form of the hemolytic and cytotoxic bacterial toxin, streptolysin O, is currently being investigated as a treatment for collagen-related disorders such as scleroderma and fibrosis. Furthermore, ML-05 may be effective in promoting wound healing and alleviating the formation of hypertrophic scars and keloids. To investigate the effects of ML-05 on wound-healing processes, in vitro wound-healing scratch assays (using human primary epidermal keratinocytes and dermal fibroblasts) and a human skin organ culture wound model were utilized. ML-05 markedly enhanced keratinocyte migration and proliferation in wound scratch assays. ML-05 did not affect either proliferation or migration of dermal fibroblasts, indicating that ML-05's effects on cell migration/proliferation may be keratinocyte-specific. ML-05 was tested in a dose-dependent manner in a skin organ culture wound model using two different application methods: Through the culture media (dermal exposure) or direct topical treatment of the wound surface. ML-05 was found to accelerate wound healing as measured by reepithelialization, particularly after topical application. Therefore, ML-05 may have potential as a wound-healing agent that promotes reepithelialization through stimulation of keratinocyte migration and proliferation. 相似文献
3.
4.
5.
Pyomyositis: characteristics at CT and MR imaging 总被引:9,自引:0,他引:9
6.
AJ Larner MRCP 《International journal of clinical practice》1994,48(5):272-274
SUMMARY A case is reported of pseudohyperphosphataemia in association with a monoclonal gammopathy of undetermined significance. 相似文献
7.
The relationship between methylxanthine intake (caffeine, theobromine and theophylline) and risk of benign proliferative epithelial disorders (BPED) of the breast was examined in a case-control study conducted in Adelaide, South Australia. The study involved 383 cases with biopsy-confirmed BPED, 192 controls whose biopsy did not show epithelial proliferation, and 383 unbiopsied community controls individually matched to cases on age and area of residence. Overall, there was relatively little variation in risk of BPED with total methylxanthine intake, or with intake of caffeine or theophylline, while there was a positive association between theobromine intake and risk of BPED, but only when cases were compared with biopsy controls. Total methylxanthine intake was positively associated with risk of BPED showing severe atypia, but the trend in risk was statistically significant only when community controls formed the comparison group. These data do not provide strong support for an association between methylxanthine intake and risk of BPED. 相似文献
8.
9.
D De AJ Kanwar S Handa 《Journal of the European Academy of Dermatology and Venereology》2006,20(7):853-859
BACKGROUND: Diagnosis of atopic dermatitis (AD) depends on clinical features because no definitive diagnostic test exists. Criteria proposed by Hanifin and Rajka (Acta Derm Venereol (Stockh) 1980; Suppl 92: 44-47) were acceptable for hospital-based studies but were found not to be suitable for field studies. A UK working party formulated clinical diagnostic criteria that could be used in both hospital and epidemiological settings. Validation studies of the criteria showed widely variable results, probably due to different clinical settings and ethnicity. AIM AND OBJECTIVE: This study was undertaken to validate Hanifin and Rajka's criteria and to assess the comparative efficacy of their criteria and the UK working party's diagnostic criteria in the diagnosis of AD in a hospital setting in North India. SUBJECTS AND METHODS: This study serially included 101 patients with AD and 48 controls of paediatric age group. The study period was from July 2003 to December 2004. RESULTS: Hanifin and Rajka's criteria (sensitivity 96%, specificity 93.75%, positive predictive value 97% (PPV) and negative predictive value (NPV) 91.84%) had a statistical advantage over the UK working party's diagnostic criteria (sensitivity 86%, specificity 95.83%, PPV 97.75% and NPV 76.67%), with a P-value < 0.005. 相似文献
10.
SUMMARY Impotence is a common symptom which can cause considerable distress to both the sufferer and his partner. The use of pharmacotherapy to improve erectile function will continue to increase as safe and effective drugs are developed. However, restoring erectile function should not be the only treatment objective. It is also essential to address personal and emotional factors in the sufferer, conflicts in his relationship with his partner, and sexual problems in his partner, all of which may be instrumental in causing or maintaining the presenting impotence. We advocate a combined approach with appropriate medical treatment and sex and couple therapy 相似文献