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1.
Iskra B Zivko M Kes P 《Acta medica Croatica : c?asopis Hravatske akademije medicinskih znanosti》2005,59(4):325-328
Myopathy and rhabdomyolysis are rare adverse effects of treatment with hydroxymethylglutaryl-coA reductase inhibitors. The risk of adverse effects is increased with the concomitant use of statin and specific drugs that can induce myopathy, in patients with liver and renal function impairment, hypothyroidism and diabetes mellitus. The clinical picture of rhabdymyolysis with acute renal failure caused by the use of simvastatin in a 54-year-old patient with diabetes mellitus and hypertension is described. 相似文献
2.
Ivancic J Gulija TK Forcic D Baricevic M Jug R Mesko-Prejac M Mazuran R 《Virus research》2005,109(1):95-105
Eleven mumps vaccine strains, all containing live attenuated virus, have been used throughout the world. Although L-Zagreb mumps vaccine has been licensed since 1972, only its partial nucleotide sequence was previously determined (accession numbers , and ). Therefore, we sequenced the entire genome of L-Zagreb vaccine strain (Institute of Immunology Inc., Zagreb, Croatia). In order to investigate the genetic stability of the vaccine, sequences of both L-Zagreb master seed and currently produced vaccine batch were determined and no difference between them was observed. A phylogenetic analysis based on SH gene sequence has shown that L-Zagreb strain does not belong to any of established mumps genotypes and that it is most similar to old, laboratory preserved European strains (1950s-1970s). L-Zagreb nucleotide and deduced protein sequences were compared with other mumps virus sequences obtained from the GenBank. Emphasis was put on functionally important protein regions and known antigenic epitopes. The extensive comparisons of nucleotide and deduced protein sequences between L-Zagreb vaccine strain and other previously determined mumps virus sequences have shown that while the functional regions of HN, V, and L proteins are well conserved among various mumps strains, there can be a substantial amino acid difference in antigenic epitopes of all proteins and in functional regions of F protein. No molecular pattern was identified that can be used as a distinction marker between virulent and attenuated strains. 相似文献
3.
D. P. Wolfer Roman J. Giger Marijana Stagliar Peter Sonderegger Hans-Peter Lipp 《Anatomy and embryology》1998,197(3):177-185
TAG-1/axonin-1 is a neuronal cell adhesion molecule of the immunoglobulin superfamily. It is predominantly expressed during
neural development and has been reported to be involved in axonal growth and pathfinding. Here, the expression of TAG-1/axonin-1
was investigated anatomically in the adult mouse brain by in situ hybridization using digoxigenin-labeled cRNA probes. Low
levels of TAG-1/axonin-1 could be detected in cerebellar granule cells, in tufted and mitral cells of the olfactory bulb,
and in pyramidal cells of area CA1 and CA3 of the hippocampus. We suspect that the expression of TAG-1/axonin-1 in these structures
of the adult brain may serve neural plasticity.
Accepted: 8 September 1997 相似文献
4.
Marijana Tadic Elisa Gherbesi Andrea Faggiano Carla Sala Stefano Carugo Cesare Cuspidi 《Journal of clinical hypertension (Greenwich, Conn.)》2022,24(7):795
Current evidence on the effects of continuous positive airway pressure (CPAP) on cardiac mechanics in patients with obstructive sleep apnea (OSA) is based on a few single studies. The authors investigated this topic through a meta‐analysis of speckle tracking echocardiography (STE) studies that provided data on left ventricular (LV) and right ventricular (RV) mechanics as assessed by global longitudinal strain (GLS). The PubMed, OVID‐MEDLINE, and Cochrane library databases were systematically analyzed to search English‐language review papers published from inception to January 31, 2022. Studies were identified by crossing the following terms: “obstructive sleep apnea”, “sleep quality”, “sleep disordered breathing”, “continuous positive airway pressure therapy”, “noninvasive ventilation”, “left ventricular hypertrophy”, “systolic dysfunction”, “global longitudinal strain”, “left ventricular mechanics”, “right ventricular mechanics”, “echocardiography” and “STE echocardiography”. The meta‐analysis, including a total of 337 patients with OSA from nine studies (follow‐up 2–24 months) showed a significant GLS improvement in both LV and RV after CPAP, standard mean difference (SMD) being 0.51±0.08, CI:0.36–0.66, p = .0001 and 0.28±0.07, CI:0.15–0.42, p = .0001), respectively. Corresponding SMD values for LV ejection fraction (LVEF) and tricuspid annular plane systolic excursion (TAPSE) were 0.20±0.06, CI:0.08–0.33, p = .001 and 0.08±0.06, CI: ‐0.04/0.20, p = .21. Our meta‐analysis suggests that: I) CPAP treatment exerts beneficial effects on biventricular function in patients with OSA; II) the assessment of cardiac mechanics by STE should be routinely recommended for monitoring cardiac function in this setting, due to limitations of conventional echocardiography in evaluating biventricular performance. 相似文献
5.
Left atrial phasic function and heart rate variability in patients with systemic sclerosis: A new part of the old puzzle 下载免费PDF全文
6.
Barbara Fumić Jasna Jablan Dominik Cinčić Marijana Zovko Končić 《Journal of microencapsulation》2018,35(1):1-12
This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either 2-hydroxypropyl-β-cyclodextrin or sulphobuthylether-β-cyclodextrin were achieved by neat grinding and were characterised by thermal analysis, X-ray powder diffraction, scanning electron microscopy and solubility testing which confirmed the complexes formation with increased solubility with respect to starting compounds. Both isoflavones, as well as their co-ground cyclodextrin complexes reduced GAG levels in the fibroblasts of MPS II and MPS III patients from 54.8–77.5%, in a dose dependent manner, without any significant cytotoxic effect. Cyclodextrin encapsulation did not change the intrinsically high effect of both DAD and GEN on the GAG level reduction in the treated cells, thus could be considered as a part of combination therapies of MPS. 相似文献
7.
8.
Heart Failure Reviews - Severe aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. Heart failure (HF) is a frequent comorbidity of this condition and... 相似文献
9.
Marijana Stojanović Vladimir Petrušić Irena Živković Aleksandra Inić-Kanada Ivana Stojićević Emilija Marinković Ljiljana Dimitrijević 《Immunologic research》2013,56(1):20-31
It is known that tetanus toxoid (TTd)-hyperimmunization induces increased titer of sera β2-glycoprotein I (β2GPI)-specific antibodies (Abs) in Balb/c mice. The concentrations of such induced anti-β2GPI Abs as well as their pathogenic potential are strongly influenced by the context of TTd application. β2GPI-specific immune response is established as a part of TTd-specific immune response by molecular mimicry mechanism due to structural homology between TTd and β2GPI. This finding is supported by the following facts: (1) cross-reactive Abs that recognize both TTd and β2GPI epitopes are present in Balb/c mice sera; (2) anti-TTd Abs secretion in splenic cultures is induced after β2GPI stimulation and vice versa. However, analyses of (1) IL-10 production following in vitro stimulation of immunized Balb/c mice splenocytes by TTd, β2GPI or glutaraldehyde-treated β2GPI and (2) specific impact of ConA and agonists of TLR2, TLR4, and TLR9 on anti-TTd and autoreactive Abs secretion strongly imply that these two branches of the TTd-induced immune response do not use identical cell populations and are regulated in a different way. Results presented in this paper describe that structural homology between foreign and self-antigens could focus mounted autoreactive immune response toward specific self-structure, but the context of antigen application, including a history of previous immune stimulations and adjuvants applied together with the antigen, are the main factors which determine the outcome of the induced immune response. 相似文献
10.
The Croatian Institute of Public Health (CIPH) collects health care related statistical data based on the Republic of Croatia''s Annual Plan of Implementation of Statistical Activities. The purpose of this study was to analyse the CIPH data retrieved from annual reports, obtained from contractual teams and institutions related to dental medicine activities, collected in respective counties and for the entire country. Material and methods: The data were collected from the Croatian Statistical Health Care Yearbook for the period from 2009 to 2013. Results: The analysis has shown the increase in the number of insured persons (5%), but the decrease in the number of persons who received care (10%) and the increase in the number of visits (14%) and general examinations (13%). The majority of the beneficiaries were from the City of Zagreb with the highest number of visits, but with a low number of general examinations included in these visits (11%); while the Zadar County had the highest number of general examinations in terms of dental health care users (90.6%) and the proportion of general examinations in visits (30%). The most common diagnosis was dental caries (43%). The incomplete and insufficient reporting from some counties, inadequate recording of diagnoses and of curative and preventive procedures could be the factors affecting the quantity and quality of obtained data. Proper and regular submissions of reports to counties'' public health institutes, regular preventive examinations, adequate recording of diagnoses and procedures would contribute positively to further health planning and the implementation of preventive measures for the improvement of oral health. Conclusion: The data analysis gives an insight into the current situation allowing on such basis further planning and conducting of activities at national and local level. Further analyses would help to get a better perspective and improvement of dental medicine activities.Key words: Dental Health Surveys, Public Health Dentistry, Health Policy, National Health Programs, Observer Variation, Health Planning, Data Interpretation, Statistical 相似文献