Management of acute traumatic atlas fractures

OBJECTIVE: A prospective review of a clinical series was performed. The treatment features of atlas fractures with and without associated axis injuries were investigated. METHODS: Twenty-nine patients were investigated. RESULTS: No displaced fractures were treated with a cervical orthosis. Patients with displaced fractures were managed with a halo vest immobilization; 96.4% patients had a solid fusion at their last follow-up evaluations. CONCLUSIONS: Isolated not displaced or combined with not displaced axis fractures atlas fractures can be treated effectively with a rigid cervical collar alone. Isolated displaced fractures or not displaced but with concurrent displaced axis fractures require immobilization by the halo vest.     

VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation

In order to elucidate the role of VCORC1 sequence variants in warfarin sensitivity, we established a complete SNP map of the VKORC1 gene locus in 200 blood donors from Western Germany. Nearly all of the genetic variability of the VKORC1 gene in Europeans is reflected by three main haplotypes. Recently described polymorphisms associated with low warfarin dose requirement (dbSNP:rs9934438; dbSNP:rs17878363) were found in complete linkage disequilibrium with the VKORC1*2 haplotype. In two patient cohorts of European origin with either increased coumarin sensitivity (n= 14) or partial coumarin resistance (n=36) the VKORC1*2 frequency varied highly significant between the two groups and also when compared to 200 blood donor controls (coumarin sensitive 96%, coumarin resistant 7%, controls 42%) thus demonstrating a strong association between these two phenotypes and the VKORC1 haplotype (p = 1.6 x 10(-8) for coumarin sensitive and p = 1.9 x 10(-8) for coumarin resistant). Analysis of database derived VKORC1 genotypes of African Americans and Chinese revealed that haplotype frequencies in these populations differ significantly from the European sample (for VKORC1*2: Europeans 42%, Chinese 95%, African Americans 14%). These observations suggest VKORC1 as principal genetic modulator of the ethnic differences in warfarin response. Since hereditary pharmacodynamic (VKORC1) and pharmacokinetic (CYP2C9) factors account for up to 50% of the inter-individual variability of the warfarin response, these genetic markers may serve as clinically relevant predictors of warfarin dosing in future studies.     

Lithuanian dentists’ knowledge,attitudes, and clinical practices regarding obstructive sleep apnea: A nationwide cross-sectional study

Objective: To investigate the knowledge, attitudes toward, and aspects of clinical practice regarding obstructive sleep apnea (OSA) among Lithuanian dentists.

Methods: A cross-sectional study was carried out during the period from December 2016 to March 2017. A survey instrument was designed and pilot tested prior to full-scale administration. Self-administered questionnaires, including a cover letter, were distributed to 550 dentists during continuing dental education programs.

Results: A total of 353 participants (64.2%) completed and returned the questionnaire. Increased years of experience were significantly associated with lesser knowledge about OSA (p < 0.05). However, there were no significant differences between general practitioners and specialists (p = 0.243). Most respondents indicated strong positive attitudes regarding OSA. The majority did not have any clinical experience regarding the management of OSA patients.

Discussion: Development of additional education and practical implementation strategies should be considered in order to overcome the examined barriers.     

Successful experience with Levitronix PediVAS for management of acute heart failure after Fontan surgery

An extracorporeal membrane oxygenation was long a golden standard in the pediatric population with acute cardiac failure for short-term mechanical circulatory support. It gives the limited availability of pediatric-sized pumps and the outcomes remain disproportionately poor. The Levitronix PediVAS system (Levitronix LLC, Waltham, MA) offers expanded options for short-term support for this population. We report our experience with the successful use of the PediVAS (left heart bypass) in the 3-year-old male patient as a bridge to recovery after Fontan surgery in acute heart failure. Short-term circulatory support with the Levitronix PediVAS has proven to be a less invasive, safe, and effective for our pediatric patient.     

Extension and flexion torque variability in ACL deficiency

Purpose  

To evaluate possible differences in knee extension and flexion torque variability in the anterior cruciate ligament—deficient (ACLD) leg and their dependence on muscle length and visual feedback (VF). Although a knee extension torque deficit is found in the ACLD leg, there is no evidence that variability in submaximal isometric knee extension and flexion torque is affected in the ACLD leg or that it depends on VF.     

Dynamics of hip joint effusion after posterior soft tissue repair in total hip arthroplasty

Dislocation after total hip replacement is more common in the early, postoperative period. Postoperative intraarticular haematoma and remaining seroma fluid and/or weakened posterior soft tissue wall may be contributing factors. Our purpose was to compare and follow with sonography the resorption of the postoperative volume of intraarticular fluid/synovial oedema after total hip arthroplasty (THA) with or without posterior soft tissue repair. Thirty-three consecutive patients with hip osteoarthritis were admitted for THA. All of them received the same type of cemented implant. Patients were randomised for posterior soft tissue repair or not. Sonography, measuring the anterior capsular distension, indicating the volume of intraarticular fluid/synovial oedema in the prosthetic hip joints, was performed after six and 12 months in all patients. At six months postoperatively greater capsular distension, i.e., remaining volume of intraarticular fluid/synovial oedema, was observed in the group with posterior soft tissue repair than in the group without. After one year the capsular distension had decreased in both groups and there was no significant difference between the groups. Our results show that posterior soft tissue repair after THA is associated with increased capsular distension during the first six months. After 12 months the volume of intraarticular fluid/synovial oedema is the same with or without posterior soft tissue repair.