全文获取类型
收费全文 | 264篇 |
免费 | 14篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 31篇 |
基础医学 | 23篇 |
口腔科学 | 47篇 |
临床医学 | 13篇 |
内科学 | 24篇 |
皮肤病学 | 9篇 |
神经病学 | 35篇 |
特种医学 | 3篇 |
外科学 | 26篇 |
综合类 | 10篇 |
预防医学 | 12篇 |
眼科学 | 2篇 |
药学 | 28篇 |
中国医学 | 2篇 |
肿瘤学 | 12篇 |
出版年
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 9篇 |
2019年 | 10篇 |
2018年 | 5篇 |
2017年 | 9篇 |
2016年 | 8篇 |
2015年 | 7篇 |
2014年 | 9篇 |
2013年 | 19篇 |
2012年 | 18篇 |
2011年 | 11篇 |
2010年 | 14篇 |
2009年 | 5篇 |
2008年 | 7篇 |
2007年 | 12篇 |
2006年 | 16篇 |
2005年 | 13篇 |
2004年 | 13篇 |
2003年 | 10篇 |
2002年 | 10篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1979年 | 2篇 |
1976年 | 4篇 |
1975年 | 5篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1967年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有278条查询结果,搜索用时 296 毫秒
1.
2.
3.
4.
5.
The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis.
A wealth of information has accumulated at an impressive pace in the recent past, both with regard to previously identified
targets for p21-activated kinases that regulate the actin cytoskeleton and cellular stress pathways and with regard to newly
identified targets and their role in cancer. Emerging data also provide new clues towards a previously unappreciated link
between these various cellular processes. The present review attempts to provide a quick tutorial to the reader about the
evolving significance of p21-activated kinases and small GTPases in breast cancer, using information from mouse models, tissue
culture studies, and human materials. 相似文献
6.
The clinical relevance of steroid hormone receptor corepressors. 总被引:2,自引:0,他引:2
Rakesh Kumar Anupama E Gururaj Ratna K Vadlamudi Suresh K Rayala 《Clinical cancer research》2005,11(8):2822-2831
7.
8.
9.
Gururaj B. Patil Kaveri S. Hallikeri Aswini Y. Balappanavar Sudheer G. Hongal P R. Sanjaya Sheetalkumar G. Sagari 《Medicina oral, patología oral y cirugía bucal》2013,18(4):e585-e590
Background: Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carcinoma (COSCC), as well as comparison with verrucous carcinoma (VC) has been less investigated.
Study Design: Immunohistochemical expression of cyclin B1 was compared with various clinicopathological features in 30 primary COSCC and 31 primary VC cases.
Result: Cyclin B1 showed significant overexpression for some clinical features for both the variants of oral squamous cell carcinoma. In histopathological variants, statistical significance was observed among grades of COSCC, as well as COSCC and its grades with VC. The concomitant increase in cyclin B1 overexpression from VC to grades COSCC was observed.
Conclusion: Our study findings draw attention to cyclin B1 overexpression is involved in early carcinogenesis, cell differentiation and tumor proliferation.
Key words:Cyclin B1, oral squamous cell carcinoma, verrucous carcinoma, head and neck cancer. 相似文献