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排序方式: 共有273条查询结果,搜索用时 31 毫秒
1.
Franka Neumer Orenci Urraca Joaquin Alonso Jesús Palencia Vicente Varea Stephan Theis Maria Rodriguez-Palmero Jos Antonio Moreno-Muoz Francisco Guarner Gigi Veereman Yvan Vandenplas Cristina Campoy 《Nutrients》2021,13(4)
The present study aims to evaluate the effects of an infant formula supplemented with a mixture of prebiotic short and long chain inulin-type oligosaccharides on health outcomes, safety and tolerance, as well as on fecal microbiota composition during the first year of life. In a prospective, multicenter, randomized, double-blind study, n = 160 healthy term infants under 4 months of age were randomized to receive either an infant formula enriched with 0.8 g/dL of Orafti®Synergy1 or an unsupplemented control formula until the age of 12 months. Growth, fever (>38 °C) and infections were regularly followed up by a pediatrician. Digestive symptoms, stool consistency as well as crying and sleeping patterns were recorded during one week each study month. Fecal microbiota and immunological biomarkers were determined from a subgroup of infants after 2, 6 and 12 months of life. The intention to treat (ITT) population consisted of n = 149 infants. Both formulae were well tolerated. Mean duration of infections was significantly lower in the prebiotic fed infants (p < 0.05). The prebiotic group showed higher Bifidobacterium counts at month 6 (p = 0.006), and higher proportions of Bifidobacterium in relation to total bacteria at month 2 and 6 (p = 0.042 and p = 0.013, respectively). Stools of infants receiving the prebiotic formula were softer (p < 0.05). Orafti®Synergy1 tended to beneficially impact total daily amount of crying (p = 0.0594). Supplementation with inulin-type prebiotic oligosaccharides during the first year of life beneficially modulates the infant gut microbiota towards higher Bifidobacterium levels at the first 6 months of life, and is associated with reduced duration of infections. 相似文献
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Macdonald Dianne Luk Gigi Quintin Eve-Marie 《Journal of autism and developmental disorders》2021,51(5):1613-1613
Journal of Autism and Developmental Disorders - The original version of this article unfortunately contained a mistake in Table 6. The column headings was repeated in the first column along with... 相似文献
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Moody Teena D. Morfini Francesca Cheng Gigi Sheen Courtney L. Kerr Wesley T Strober Michael Feusner Jamie D. 《Brain imaging and behavior》2021,15(3):1235-1252
Brain Imaging and Behavior - Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are characterized by distorted perception of appearance, yet no studies have directly compared the neurobiology... 相似文献
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Algebraic reconstruction technique for parallel imaging reconstruction of undersampled radial data: Application to cardiac cine
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Norman G Joseph G Ebenezer G Rao SP Job CK 《International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association》2003,71(1):18-21
This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin. 相似文献
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Jiang Bian Tianchen Lyu Alexander Loiacono Tonatiuh Mendoza Viramontes Gloria Lipori Yi Guo Yonghui Wu Mattia Prosperi Thomas J George Jr Christopher A Harle Elizabeth A Shenkman William Hogan 《J Am Med Inform Assoc》2020,27(12):1999
ObjectiveTo synthesize data quality (DQ) dimensions and assessment methods of real-world data, especially electronic health records, through a systematic scoping review and to assess the practice of DQ assessment in the national Patient-centered Clinical Research Network (PCORnet).Materials and MethodsWe started with 3 widely cited DQ literature—2 reviews from Chan et al (2010) and Weiskopf et al (2013a) and 1 DQ framework from Kahn et al (2016)—and expanded our review systematically to cover relevant articles published up to February 2020. We extracted DQ dimensions and assessment methods from these studies, mapped their relationships, and organized a synthesized summarization of existing DQ dimensions and assessment methods. We reviewed the data checks employed by the PCORnet and mapped them to the synthesized DQ dimensions and methods.ResultsWe analyzed a total of 3 reviews, 20 DQ frameworks, and 226 DQ studies and extracted 14 DQ dimensions and 10 assessment methods. We found that completeness, concordance, and correctness/accuracy were commonly assessed. Element presence, validity check, and conformance were commonly used DQ assessment methods and were the main focuses of the PCORnet data checks.DiscussionDefinitions of DQ dimensions and methods were not consistent in the literature, and the DQ assessment practice was not evenly distributed (eg, usability and ease-of-use were rarely discussed). Challenges in DQ assessments, given the complex and heterogeneous nature of real-world data, exist.ConclusionThe practice of DQ assessment is still limited in scope. Future work is warranted to generate understandable, executable, and reusable DQ measures. 相似文献