全文获取类型
收费全文 | 1707篇 |
免费 | 132篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 113篇 |
妇产科学 | 50篇 |
基础医学 | 176篇 |
口腔科学 | 51篇 |
临床医学 | 122篇 |
内科学 | 368篇 |
皮肤病学 | 29篇 |
神经病学 | 87篇 |
特种医学 | 40篇 |
外国民族医学 | 2篇 |
外科学 | 256篇 |
综合类 | 39篇 |
预防医学 | 248篇 |
眼科学 | 48篇 |
药学 | 132篇 |
中国医学 | 11篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 18篇 |
2022年 | 41篇 |
2021年 | 64篇 |
2020年 | 30篇 |
2019年 | 44篇 |
2018年 | 68篇 |
2017年 | 41篇 |
2016年 | 59篇 |
2015年 | 54篇 |
2014年 | 67篇 |
2013年 | 75篇 |
2012年 | 107篇 |
2011年 | 110篇 |
2010年 | 71篇 |
2009年 | 43篇 |
2008年 | 82篇 |
2007年 | 89篇 |
2006年 | 95篇 |
2005年 | 86篇 |
2004年 | 102篇 |
2003年 | 83篇 |
2002年 | 72篇 |
2001年 | 42篇 |
2000年 | 42篇 |
1999年 | 32篇 |
1998年 | 22篇 |
1997年 | 9篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 16篇 |
1993年 | 9篇 |
1992年 | 18篇 |
1991年 | 14篇 |
1990年 | 13篇 |
1989年 | 23篇 |
1988年 | 16篇 |
1987年 | 15篇 |
1986年 | 12篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1979年 | 2篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 3篇 |
排序方式: 共有1844条查询结果,搜索用时 15 毫秒
1.
2.
3.
Hazel B Breitz Richard E Wendt Michael S Stabin Sui Shen William D Erwin Joseph G Rajendran Janet F Eary Lawrence Durack Ebrahim Delpassand William Martin Ruby F Meredith 《Journal of nuclear medicine》2006,47(3):534-542
166Ho-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonate (DOTMP) is a tetraphosphonate molecule radiolabeled with 166Ho that localizes to bone surfaces. This study evaluated pharmacokinetics and radiation-absorbed dose to all organs from this beta-emitting radiopharmaceutical. METHODS: After two 1.1-GBq administrations of 166Ho-DOTMP, data from whole-body counting using a gamma-camera or uptake probe were assessed for reproducibility of whole-body retention in 12 patients with multiple myeloma. The radiation-absorbed dose to normal organs was estimated using MIRD methodology, applying residence times and S values for 166Ho. Marrow dose was estimated from measured activity retained after 18 h. The activity to deliver a therapeutic dose of 25 Gy to the marrow was determined. Methods based on region-of-interest (ROI) and whole-body clearance were evaluated to estimate kidney activity, because the radiotracer is rapidly excreted in the urine. The dose to the surface of the bladder wall was estimated using a dynamic bladder model. RESULTS: In clinical practice, gamma-camera methods were more reliable than uptake probe-based methods for whole-body counting. The intrapatient variability of dose calculations was less than 10% between the 2 tracer studies. Skeletal uptake of 166Ho-DOTMP varied from 19% to 39% (mean, 28%). The activity of 166Ho prescribed for therapy ranged from 38 to 67 GBq (1,030-1,810 mCi). After high-dose therapy, the estimates of absorbed dose to the kidney varied from 1.6 to 4 Gy using the whole-body clearance-based method and from 8.3 to 17.3 Gy using the ROI-based method. Bladder dose ranged from 10 to 20 Gy, bone surface dose ranged from 39 to 57 Gy, and doses to other organs were less than 2 Gy for all patients. Repetitive administration had no impact on tracer biodistribution, pharmacokinetics, or organ dose. CONCLUSION: Pharmacokinetics analysis validated gamma-camera whole-body counting of 166Ho as an appropriate approach to assess clearance and to estimate radiation-absorbed dose to normal organs except the kidneys. Quantitative gamma-camera imaging is difficult and requires scatter subtraction because of the multiple energy emissions of 166Ho. Kidney dose estimates were approximately 5-fold higher when the ROI-based method was used rather than the clearance-based model, and neither appeared reliable. In future clinical trials with 166Ho-DOTMP, we recommend that dose estimation based on the methods described here be used for all organs except the kidneys. Assumptions for the kidney dose require further evaluation. 相似文献
4.
A Alzahrani M Anvari B Dallemagne D Mutter J Marescaux 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2007,11(1):97-100
OBJECTIVE: We report on 3 patients who underwent laparoscopic antireflux procedures for persistent symptoms of GERD after biopolymer injection. METHODS: Experienced laparoscopic surgeons completed all 3 procedures laparoscopically. In 2 patients, there was an extramural extravasation of the polymer outside and adherent to the esophageal wall. In these patients, a partial posterior fundoplication was used. The third patient, who had the polymer material deposits removed preoperatively by endoscopic mucosal resection, underwent a Nissen fundoplication. RESULTS: Postoperative recovery was uneventful in all cases. At follow-up of 6 to 12 months, all patients were symptom free, off medical therapy, and experiencing no dysphagia. CONCLUSION: Surgical therapy for patients after failed biopolymer injection is safe and effective. The choice of surgery may depend on whether the polymer mass can be removed preoperatively. 相似文献
5.
S Ebrahim 《Journal of epidemiology and community health》1997,51(5):469-471
6.
7.
8.
9.
10.