全文获取类型
收费全文 | 4352篇 |
免费 | 181篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 131篇 |
妇产科学 | 113篇 |
基础医学 | 969篇 |
口腔科学 | 131篇 |
临床医学 | 372篇 |
内科学 | 621篇 |
皮肤病学 | 62篇 |
神经病学 | 328篇 |
特种医学 | 108篇 |
外科学 | 419篇 |
综合类 | 27篇 |
一般理论 | 1篇 |
预防医学 | 265篇 |
眼科学 | 164篇 |
药学 | 311篇 |
中国医学 | 3篇 |
肿瘤学 | 466篇 |
出版年
2018年 | 36篇 |
2015年 | 47篇 |
2014年 | 58篇 |
2013年 | 112篇 |
2012年 | 121篇 |
2011年 | 124篇 |
2010年 | 141篇 |
2009年 | 89篇 |
2008年 | 150篇 |
2007年 | 132篇 |
2006年 | 137篇 |
2005年 | 128篇 |
2004年 | 201篇 |
2003年 | 174篇 |
2002年 | 223篇 |
2001年 | 123篇 |
2000年 | 118篇 |
1999年 | 116篇 |
1998年 | 58篇 |
1997年 | 38篇 |
1996年 | 32篇 |
1995年 | 41篇 |
1994年 | 39篇 |
1993年 | 36篇 |
1992年 | 86篇 |
1991年 | 78篇 |
1990年 | 67篇 |
1989年 | 69篇 |
1988年 | 70篇 |
1987年 | 66篇 |
1986年 | 52篇 |
1985年 | 60篇 |
1984年 | 40篇 |
1983年 | 41篇 |
1982年 | 34篇 |
1981年 | 30篇 |
1980年 | 46篇 |
1979年 | 49篇 |
1978年 | 39篇 |
1976年 | 32篇 |
1975年 | 32篇 |
1974年 | 64篇 |
1973年 | 35篇 |
1972年 | 45篇 |
1971年 | 65篇 |
1970年 | 78篇 |
1969年 | 100篇 |
1968年 | 101篇 |
1967年 | 119篇 |
1966年 | 125篇 |
排序方式: 共有4538条查询结果,搜索用时 0 毫秒
1.
Setting goals to maintain hope. 总被引:3,自引:0,他引:3
2.
Abstract – Aim: To evaluate the pulp and periodontal healing of laterally luxated permanent teeth. Material and methods: Patients presenting with lateral luxation of permanent teeth during 2001–2002 were enrolled in this clinical study. Laterally luxated teeth were repositioned and splinted with a TTS/composite resin splint for 4 weeks. Immediate (prophylactic) root‐canal treatment was performed in severely luxated teeth with radiographically closed apices. All patients received tetracycline for 10 days. Re‐examinations were performed after 1, 2, 3, 6, 12 and 48 months. Results: All 47 laterally luxated permanent teeth that could be followed over the entire study period survived. In 10 teeth (21.3%), a prophylactic root‐canal treatment was performed within 2 weeks following injury. The remaining 37 teeth showed the following characteristics at the 4‐year re‐examination: 19 teeth (51.4%) had pulp survival (no clinical or radiographic signs or symptoms), nine teeth (24.3%) presented with pulp canal calcification, and pulp necrosis was seen in another nine teeth (24.3%), within the first year after trauma. None of the teeth with a radiographically open apex at the time of lateral luxation showed complications. External root resorption was only seen in one tooth. Conclusions: Laterally luxated permanent teeth with incomplete root formation have a good prognosis, with all teeth surviving in this study. The most frequent complication was pulp necrosis that was only seen in teeth with closed apices. 相似文献
3.
A. Fuerst S. Derungs B.
Von Rechenberg J. A. Auer J. Schense J. Watson 《Transboundary and Emerging Diseases》2007,54(2):107-112
To describe the treatment of a subchondral bone cyst in the proximal phalanx with parathyroid hormone peptide‐enriched fibrin hydrogel in a warmblood filly. The cyst was localized with computer‐assisted orthopaedic surgery, then curetted and finally filled with parathyroid hormone fragment peptide 1–34 (PTH1−34) covalently attached to a fibrin hydrogel. The cyst healed quickly without any complications. This result supports the hypothesis that PTH1−34 delivered locally in a fibrin hydrogel may improve the postoperative prognosis of surgical management of subchondral bone cysts in horses. Subchondral bone cysts are fairly common in horses. Especially in older horses, the prognosis is poor, even after surgical curettage. Therefore, different management protocols have been investigated in conjunction with surgical curettage to improve prognosis. Locally delivered PTH1−34 seems to be a new method in the treatment of subchondral bone cysts. 相似文献
4.
5.
Jennifer P. Friedberg Marios N. Adonis Heather A. Von Bergen Sonia Suchday 《Stress and health》2005,21(1):53-60
Exposure to trauma and stress has been linked with poor health, while forgiveness appears to be positively associated with health outcomes. The current study investigates whether traits such as forgiveness and ruminative tendencies predict levels of trauma and stress experienced by New York City residents on the 1‐year anniversary of the September 11th terrorist attack. Seventy‐one students and staff members (57 females, 14 males) of a graduate school in New York City were administered the Impact of Events Scale, the Perceived Stress Scale, and questionnaires designed for the purpose of this study to measure ruminative tendencies and forgiveness on September 11, 2002. Rumination predicted levels of trauma (p < 0.05) and perceived stress (p < 0.01). Lower levels of forgiveness predicted perceived stress (p < 0.05), but not trauma. Rumination mediated the relationship between forgiveness and perceived stress. These findings suggest that individuals with higher levels of rumination have an elevated risk of experiencing trauma and stress‐related symptoms following a traumatic event. Forgiveness is associated with lower levels of stress, but not trauma, perhaps because trauma is an extreme form of stress. Forgiveness appears to serve as a buffer against stress more so in individuals with low levels of rumination than in individuals with high levels of rumination. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
6.
Response rates,duration of response,and dose response effects in phase I studies of antineoplastics 总被引:4,自引:0,他引:4
Summary Over a period of 14 years, 7,960 patients were treated in 228 phase I trials. In these patients, there were 75 complete and 432 partial responses for an overall objective response rate of 6%. Complete responses lasted a median of six months (range 1–18), while partial responses lasted a median of three months (range 1–17). Of note is that no drug has made it to the market which has not had a response in phase I trials. Responses were noted in very diverse histologic types of tumors. Although there were responses at doses which were as low as 3–5% of the recommended dose for phase II trials, the majority of responses did occur at 80–120% of the dose recommended for phase II trials. Although the response rate in phase I trials is indeed low, responses do occur. This response rate information should help the clinician provide facts for the patient considering a phase I trial with new anticancer agents. These findings also emphasize that although phase I trials are characteristically dose-finding studies, if no responses are noted in phase I studies, it is unlikely the drug will be used routinely in the clinic. 相似文献
7.
In order to assess the clinical usefulness of benzodiazepine brief therapy with planned tapering, prazepam as drops was administered to 40 psychiatric outpatients suffering from generalized anxiety disorder. After a one-week placebo period, the patients received prazepam 40 mg daily (i.e., 10 drops in the morning, 10 drops at noon and 20 drops in the evening) during 3 weeks, with the possibility to adjust the doses after one week. The doses were then tapered at 4 mg/d (i.e., 1 drop in the morning, 1 drop at noon and 2 drops in the evening) until complete suppression of the treatment. The assessments, performed before the placebo period, at inclusion, after 1 and 3 weeks of active treatment, and after 1 and 2 weeks of tapering, included the Hamilton anxiety scale, the Lader tranquillizer withdrawal rating scale, and the collection of side effects; moreover, the patients completed daily a visual analogue scale. Results showed a very marked anxiolytic effect of prazepam with an already very significant decrease in the scores on the various scales after 1 week of treatment when the daily dose was significantly reduced. Three quarters of the patients were able to take part in the tapering of prazepam doses without exhibiting any reappearance of anxious symptomatology, rebound anxiety, or withdrawal symptoms. The tolerance of the treatment was rated as good or very good in 91.9% of the patients. This study demonstrates the possibility of a brief anxiolytic treatment followed by tapering in a majority of patients with generalized anxiety disorders. For this strategy, the availability of a drop form represents an obvious advantage. 相似文献
8.
9.
T Y Nakagawa H Von Grafenstein J E Sears J Williams C A Janeway R A Flavell 《European journal of immunology》1991,21(11):2851-2855
CD4+ T cells recognize processed exogenous antigen in the form of peptides bound to syngeneic major histocompatibility complex class II molecules on antigen-presenting cells. We have developed a novel and convenient method to synthesize and map CD4+ T cell epitopes of cloned antigens using polymerase chain reaction (PCR)-directed construction of genes expressing recombinant protein fragments. Unique restriction sites incorporated into the PCR primers were employed for the unidirectional cloning of gene fragments into a bacterial expression vector that can be induced to high-level expression. The bacterial lysate could be used directly in T cell proliferation assays. Overlapping recombinant fragments spanning the entire protein were generated and tested. The length of the sequence containing the epitope was further reduced by utilizing PCR to generate 3' truncations. Finally, a small number of overlapping peptides spanning a sequence of 39 amino acids were synthesized to identify a thirteen-amino acid peptide epitope within chicken transferrin that stimulates the T helper cell clone D10.G4.1. PCR-directed construction of fragments of antigen allows for optimal design of strategies for the mapping and analysis of CD4+ T cell epitopes. 相似文献
10.
S Trottier K Stenberg I A Von Rosen C Svanborg 《The Pediatric infectious disease journal》1991,10(8):578-584
The role of Haemophilus influenzae in acute purulent conjunctivitis was studied during an outbreak among children in day care. Five day-care centers contributed 20 cases and 35 controls. All the children were subjected to culture of the nasopharynx and the eyes. H. influenzae was carried in the nasopharynx of 53% of the children (range between day care centers, 20 to 91%). Of the 20 children with acute conjunctivitis 8 had eye cultures positive for H. influenzae, 2 had Moraxella and the remaining were culture-negative. Ten colonies of H. influenzae were isolated from each positive culture and identified by capsular type, biotype and multi-locus enzyme electrophoresis. All but one of the isolates were nonencapsulated. They belonged to 4 biotypes and 8 electrophoretic types. The same strain was recovered from the eyes and nasopharynx of the symptomatic children, suggesting that the H. influenzae in the eyes originated from the nasopharynx. There was no evidence for spread of the same H. influenzae strains between day-care centers. Even within each center the Haemophilus strains recovered from the eyes varied among the symptomatic children. The in vitro capacity to attach to oropharyngeal epithelial cells was not increased among the H. influenzae recovered from the eyes. The results question if the majority of conjunctivitis cases were caused by H. influenzae and suggested that eyes were colonized with the nasopharyngeal carrier strain rather than infected by an isolate with special virulence for the eye. 相似文献