全文获取类型
收费全文 | 4034篇 |
免费 | 363篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 147篇 |
妇产科学 | 67篇 |
基础医学 | 453篇 |
口腔科学 | 77篇 |
临床医学 | 462篇 |
内科学 | 880篇 |
皮肤病学 | 240篇 |
神经病学 | 224篇 |
特种医学 | 259篇 |
外科学 | 443篇 |
综合类 | 142篇 |
预防医学 | 432篇 |
眼科学 | 73篇 |
药学 | 405篇 |
中国医学 | 1篇 |
肿瘤学 | 122篇 |
出版年
2021年 | 38篇 |
2018年 | 47篇 |
2017年 | 42篇 |
2016年 | 66篇 |
2015年 | 69篇 |
2014年 | 78篇 |
2013年 | 169篇 |
2012年 | 125篇 |
2011年 | 128篇 |
2010年 | 95篇 |
2009年 | 116篇 |
2008年 | 126篇 |
2007年 | 126篇 |
2006年 | 120篇 |
2005年 | 109篇 |
2004年 | 100篇 |
2003年 | 100篇 |
2002年 | 99篇 |
2001年 | 86篇 |
2000年 | 109篇 |
1999年 | 127篇 |
1998年 | 87篇 |
1997年 | 71篇 |
1996年 | 87篇 |
1995年 | 78篇 |
1994年 | 77篇 |
1993年 | 61篇 |
1992年 | 138篇 |
1991年 | 86篇 |
1990年 | 106篇 |
1989年 | 111篇 |
1988年 | 116篇 |
1987年 | 109篇 |
1986年 | 95篇 |
1985年 | 93篇 |
1984年 | 93篇 |
1983年 | 57篇 |
1982年 | 49篇 |
1981年 | 52篇 |
1980年 | 41篇 |
1979年 | 45篇 |
1978年 | 51篇 |
1977年 | 42篇 |
1976年 | 42篇 |
1975年 | 34篇 |
1974年 | 42篇 |
1973年 | 49篇 |
1972年 | 37篇 |
1971年 | 48篇 |
1970年 | 40篇 |
排序方式: 共有4438条查询结果,搜索用时 15 毫秒
1.
D Monnier† C Vidal‡ L Martin§ A Danzon¶ F Pelletier† E Puzenat† MP Algros†† D Blanc† R Laurent† PH Humbert† F Aubin† 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1237-1242
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence of 0.8 to five cases per 1 million people per year. OBJECTIVE: To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type of treatment and outcome of DFSP from 1982 to 2002. METHODS: Using data from the population-based cancer registry, 66 patients with pathologically proved DFSP were included (fibrosarcomatous DFSP were excluded). Each patient lived in one of the four departments of Franche-Comté (overall population of 1 million people) at the time of diagnosis. The main data sources came from public and private pathology laboratories and medical records. The rules of the International Agency for Research on Cancer were applied. RESULTS: The estimated incidence of DFSP in Franche-Comté was about three new cases per 1 million people per year. Male patients were affected 1.2 times as often as female patients were. The trunk (45%) followed by the proximal extremities (38%) were the most frequent locations. DFSP occurred mainly in young adults between 20 and 39 years of age. Mean age at diagnosis was 43 years, and the mean delay in diagnosis was 10.08 years. Our 66 patients initially underwent a radical local excision. Among them, 27% experienced one or more local recurrences during 9.6 years of follow-up. There was one regional lymph node recurrence without visceral metastases. These recurrences were significantly related to the initial peripheral resection margins. We observed a local recurrence rate of 47% for margins less than 3 cm, vs. only 7% for margins ranging from 3 to 5 cm [P=0.004; OR=0.229 (95%, CI=0.103-0.510)]. The mean time to a first local recurrence was 2.65 years. Nevertheless, there was no death due to the DFSP course at the end of the follow-up, and the final outcome was favourable. CONCLUSION: Our study emphasizes the importance of wide local excision with margins of at least 3 cm in order to prevent local recurrence. However, the recent development of inhibitors of signal transduction by the PDGFB pathway should soon modify the surgical strategy, which is often too mutilating. 相似文献
2.
3.
4.
5.
6.
L. TIMMER-DE MIK M.D. D.M. BROEKHUIJSEN-VAN HENTEN M.D. † J.M. OLDHOFF M.D. PH.D. D.B. DE GEER M.D. ‡ V. SIGURDSSON M.D. PH.D. S.G.M.A. PASMANS M.D. PH.D. 《Pediatric dermatology》2009,26(3):358-360
Abstract: In Sweet's syndrome, the essential features are the characteristic morphology of the lesions, their histologic appearance, the dramatic response to corticosteroids and the absence of scarring. We report an 8-month-old infant in whom Sweet's syndrome was diagnosed and who developed acquired cutis laxa in the skin lesions. 相似文献
7.
HUGH F. MOLLOY F.A.C.D. ERIC LAMONT-GREGORY M.SC. CHRIS IDZIKOWSKI PH.D. F.B.PS.S. TERENCE J. RYAN D.M. F.R.C.P. 《International journal of dermatology》1993,32(9):668-672
Background. Extensive questioning of patients with a wide variety of skin disorders led to the impression that nocturnal overheating was probably an important factor in the initiation and the perpetuation of many skin disorders. Methods. In order to test the hypothesis, 12 “clean-skinned” subjects (6M/6F) aged 18 to 45 years were monitored electronically every 30 seconds during an 8 hour sleep period (2300 to 0700 hours), sleeping under a standard 10 tog duvet. Results. All the subjects were too hot by 3 to 4°C. All showed changes in their EEG patterns with reduced REM sleep, increased awakenings, and all showed changes in their sleep stage patterns. In addition, they all showed evidence of increased sweating in the “heat-sink” area. Conclusions. The mechanisms where by such changes could be implicated in the precipitation and perpetuation of skin disease are discussed. “Lifestyle” modification as a very effective, noninvasive, therapeutic regime is recommended. Further research along these lines would probably be very valuable and instructive. 相似文献
8.
Dr. James Hui Ph.D. Dr. Yow-Ming C. Wang Ph.D. Dr. Appavu Chandrasekaran Ph.D. Dr. Douglas R. Geraets Pharm.D. Dr. James H. Caldwell M.D. Dr. Larry W. Robertson Ph.D. Dr. Richard H. Reuning Ph.D. 《Pharmacotherapy》1994,14(5):607-612
Study Objective . To compare digoxin tablets and liquid-filled capsules with respect to excretion of the drug and its metabolites in urine and feces at steady state. Design . A randomized, crossover trial, each period lasting 3 weeks, with no washout period. Setting . A university hospital. Patients . Six patients, five of whom were elderly, with histories of gastrointestinal disorders, such as hypochlorhydria, intestinal bacterial overgrowth, and inflammatory bowel disease. Interventions . The patients received digoxin once/day in either tablet or capsule form for 3 weeks, and then were switched to the other formulation. Total urinary and fecal excretion from the last 3 days of each regimen were analyzed for the drug and metabolites. Measurements and Main Results . No statistically significant differences were found between tablets and capsules in recovery of digoxin or its metabolites in urine or feces (p=0.05). One subject had a 4-fold increase in urinary drug excretion and 50% decrease in fecal excretion after taking the capsules compared with tablets. Intersubject variability in extent and type of metabolite excretion was greater than intrasubject variability. Conclusions . Fecal analyses may be an accurate way to classify patients as formers of digoxin reduction products. 相似文献
9.
Glucose metabolism in injured tissue: a longitudinal study 总被引:1,自引:0,他引:1
Injured tissue is characterized by increased glucose uptake and increased lactate production as compared to normal tissue. These metabolic changes have been attributed to the presence of inflammatory cells in injured tissues. To correlate these metabolic changes with changes in the inflammatory cell population at various times after injury, we studied the lambda-carrageenan hindlimb wound model in anesthetized rats. Perfusion studies demonstrated that at 3 and 5 days after injury glucose uptake was increased in injured hindlimbs, compared with hindlimbs from pair-fed control animals. At 3, 5, and 10 days after injury, lactate production from glucose was increased in injured hindlimbs, compared with hindlimbs from pair-fed control animals. These metabolic changes were not related to differences in body weight or food intake. There was no difference in glucose oxidation or in oxygen consumption in injured hindlimbs, compared with hindlimbs from pair-fed control animals. The increased glucose uptake and increased lactate production from glucose was coincident with the presence of inflammatory cells--predominantly macrophages--at the site of injury. It is suggested that the glucose metabolism in injured tissue reflects the metabolism of the inflammatory cells at the site of injury. 相似文献
10.
The association of non-insulin-dependent diabetes mellitus with perceived quality of life in a biethnic population: the San Luis Valley Diabetes Study.
下载免费PDF全文
![点击此处可从《American journal of public health》网站下载免费的PDF全文](/ch/ext_images/free.gif)
E M Caldwell J Baxter C M Mitchell S M Shetterly R F Hamman 《American journal of public health》1998,88(8):1225-1229
OBJECTIVES: This study evaluated the association between quality of life and non-insulin-dependent diabetes mellitus (NIDDM) status, and whether this association differs between Hispanics and non-Hispanic Whites. METHODS: Between 1986 and 1989, cross-sectional data on perceived quality of life (PQOL) were collected from 223 persons with NIDDM and 753 non-diabetic subjects. RESULTS: After adjustment, persons with NIDDM rated their PQOL significantly lower than did control subjects. The relationship of diabetes and PQOL did not differ by ethnicity. The number of complications of diabetes was not associated with lower PQOL scores. CONCLUSIONS: Control and treatment strategies should reflect an understanding of the impact that diabetes has on social functioning, leisure activities, and physical and mental health. 相似文献