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Evaluation of the congenital supravalvular aortic stenosis by different imaging modalities
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Ahmet Guner MD Nuri Havan MD Sabahattin Gunduz MD Taylan Akgun MD Busra Guvendi MD Gokhan Kahveci MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(9):1376-1378
A 36‐year‐old female was admitted to hospital exhibiting chest pain, dyspnea, and a heart murmur on the right upper sternal border, radiating to both carotid arteries. The blood pressure of the patient's right arm exceeded the pressure in the left by 25 mm Hg (Coanda effect). In spite of laboratory results that did not fall outside the expected range, the left ventricle was revealed to be hypertrophic following electrocardiography. Transthoracic echocardiography revealed a severe supravalvular aortic stenosis (SVAS) with a peak Doppler velocity of 6.04 cm/s and an estimated mean pressure gradient of 89 mm Hg, with moderate aortic and mitral regurgitation. Contrast‐enhanced computed tomography (CCT) indicated a partial hourglass‐shaped narrowing of the ascending aorta. Lesions associated with supravalvular stenosis of the pulmonary artery, patent ductus arteriosus, and aortic coarctation were ruled out by the CCT. Congenital SVAS is a rare heart condition, and three anatomically distinct forms have been described. The most common type is the “hourglass,” which produces a marked thickening and disorganization of the aortic tissue, producing a constricting annular ridge at the superior margin of the sinuses of Valsalva. 相似文献
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Gulser Esen Besli Cigdem Ulukaya Durakbasa Sema Yildirim Murat Acar Busra Cakir 《Pediatrics international》2015,57(6):1169-1171
Aortic dissection is extremely rare in children. Although it usually presents with severe chest pain, atypical clinical presentations mimicking various illnesses may cause misdiagnosis. In this report, the case of a 14‐year‐old boy with symptoms suggestive of acute abdomen, which was finally diagnosed as aortic dissection, is discussed. 相似文献
4.
Safa Kemal Kaptan Busra Ozen Dursun Mark Knowles Nusrat Husain Filippo Varese 《Clinical psychology & psychotherapy》2021,28(4):784-806
This review systematically synthesized existing literature on group protocols of eye movement desensitization and reprocessing (EMDR) therapy for treating a range of mental health difficulties in adults and children. We conducted database searches on PsychINFO, EMBASE, MEDLINE, Web of Science, The Cochrane Library and Francine Shapiro Library up to May 2020, using PRISMA guidelines. Studies were included if they used at least one standardized outcome measure, if they present a quantitative data on the effect of group EMDR protocols on mental health difficulties and if they were published in English. Twenty-two studies with 1739 participants were included. Thirteen studies examined EMDR Integrative Group Treatment Protocol (IGTP), four studies examined EMDR Group Traumatic Episode Protocol (G-TEP), four studies EMDR Integrative Group Treatment Protocol for Ongoing Traumatic Stress and one study considered EMDR Group Protocol with Children. Of the 22 studies included, 12 were one-arm trials and 10 were two-arm trials. We assessed risk of bias using a revised Tool to Assess Risk of Bias in Randomized Trials (ROB 2) and Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I). Overall, the results suggested that Group EMDR protocols might be an effective tool in improving a wide range of mental health-related outcomes including posttraumatic stress disorder (PTSD), depression and anxiety. However, the included studies are limited to methodological challenges. The limitations and future directions are discussed. 相似文献
5.
Yasemin Budama-Kilinc Serda Kecel-Gunduz Burak Ozdemir Bilge Bicak Gizem Akman Busra Arvas Feray Aydogan Cigdem Yolacan 《Archiv der Pharmazie》2020,353(11):2000137
The aim of this study was to develop a novel nanosize drug candidate for cancer therapy. For this purpose, (S)-methyl 2-[(7-hydroxy-2-oxo-4-phenyl-2H-chromen-8-yl)methyleneamino]-3-(1H-indol-3-yl)propanoate (ND3) was synthesized by the condensation reaction of 8-formyl-7-hydroxy-4-phenylcoumarin with l -tryptophan methyl ester. Its controlled release formulation was prepared and characterized by different spectroscopic and imaging methods. The cytotoxic effects of ND3 and its controlled release formulation were evaluated against MCF-7 and A549 cancer cell lines, and it was found that both of them have a toxic effect on cancer cells. For drug design and process development, the molecular docking analysis technique helps to clarify the effects of some DNA-targeted anticancer drugs to determine the interaction mechanisms of these drugs on DNA in a shorter time and at a lower cost. By using the molecular docking analysis and DNA binding assays, the interaction between the synthesized compound and DNA was elucidated and non-binding interactions were also determined. To predict the pharmacokinetics, and thereby accelerate drug discovery, the absorption, distribution, metabolism, excretion and toxicity values of the synthesized compound were determined by in silico methods. 相似文献
6.
Teke Kerem Yaprak Bayrak Busra Yuksekkaya Mustafa Uslubas Ali Kemal Kosem Mehmet Esat Yilmaz Hasan Kara Onder Dillioglugil Ozdal 《International urology and nephrology》2020,52(12):2289-2299
International Urology and Nephrology - We aimed to assess an “Immunological Profile (IP)” including CD8+ and FoxP3+ T lymphocytes for renal cell carcinoma (RCC) to evaluate its effects... 相似文献
7.
Self-healing is the capability of materials to repair themselves after the damage has occurred, usually through the interaction between molecules or chains. Physical and chemical processes are applied for the preparation of self-healing systems. There are different approaches for these systems, such as heterogeneous systems, shape memory effects, hydrogen bonding or covalent–bond interaction, diffusion, and flow dynamics. Self-healing mechanisms can occur in particular through heat and light exposure or through reconnection without a direct effect. The applications of these systems display an increasing trend in both the R&D and industry sectors. Moreover, self-healing systems and their energy storage applications are currently gaining great importance. This review aims to provide general information on recent developments in self-healing materials and their battery applications given the critical importance of self-healing systems for lithium-ion batteries (LIBs). In the first part of the review, an introduction about self-healing mechanisms and design strategies for self-healing materials is given. Then, selected important healing materials in the literature for the anodes of LIBs are mentioned in the second part. The results and future perspectives are stated in the conclusion section. 相似文献
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Huseyin Demirors Esra Circi Rahmi Can Akgun Nefise Cagla Tarhan Nuri Cetin Sercan Akpinar Ismail Cengiz Tuncay 《International orthopaedics》2010,34(4):531-536
The aim of this study was to investigate the correlation of tendon integrity following open cuff repairs with functional and
isokinetic strength measurements. Twenty-six shoulders of 25 patients were included in this study. At the final follow-up,
14 repairs (53.8%) were intact and 12 repairs (46.2%) had failed on magnetic resonance imaging (MRI). Mean UCLA score at latest
follow-up was 28.5 and mean Constant score was 80.3. Constant scores were found to be significantly low for the failed group.
Age was found to be significantly related to failed repair. Fatty infiltration stage in the failed repair group was significantly
high, and a strong positive correlation for both groups existed pre and postoperatively. When both groups were compared, the
failed group was found to have significantly low measurements at extension and internal rotation. Despite high failure rates,
functional results were satisfactory. Increased age and fatty infiltration stage decrease success. 相似文献
10.
Eva Shrestha Jonathan B. Coulter William Guzman Busra Ozbek Megan M. Hess Luke Mummert Sarah E. Ernst Janielle P. Maynard Alan K. Meeker Christopher M. Heaphy Michael C. Haffner Angelo M. De Marzo Karen S. Sfanos 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(32)