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Stamatiou K Alevizos A Petrakos G Lentzas I Papathanasiou M Mariolis A Panagopoulos P Sofras F 《Clinical and experimental obstetrics & gynecology》2007,34(2):85-87
PURPOSE: The purpose of this study was to compare the efficacy and safety profile of twice daily versus the conventional three daily intake of cefaclor administrated orally for five to seven days in the treatment of asymptomatic bacteriuria or acute cystitis in pregnant women with a history of hypersensitivity to penicillin. METHODS: Between August 2003 and August 2004, 63 pregnant women with a positive urine culture and a history of suspicion of hypersensitivity to penicillin were randomly divided into two groups. The women in the first group received 500 mg of cefaclor while those in the second group received 750 mg of cefaclor for five to seven days. Laboratory and clinical results were assessed a week and a month after complettion of the therapy. RESULTS: Final therapy (bacteriologic eradication) succeeded in 93.7% (30/32) of the first group and in 90.3% (28/31) of the second group. CONCLUSION: Dosage of cefaclor at 750 mg is as effective as conventional cefaclor at 500 mg and better tolerated. 相似文献
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Stamatiou K Alevizos A Mariolis A Fanou D Alevizou A Michalodimitrakis E Sofras F 《The Canadian journal of urology》2007,14(2):3502-3506
The general consensus about prostatic duct adenocarcinomas is that they have a rather aggressive biological behavior. In addition, studies or reports of latent adenocarcinoma of the prostatic duct in necropsy material are scarce in the literature. We report here three cases of adenocarcinoma of the prostatic duct that were found incidentally among 39 cases of latent acinar prostate adenocarcinomas in necropsy material. We examined the morphologic and histological features of these prostatic duct adenocarcinomas, in order to better understand their biological behavior. We identified two cases of mixed ductal-acinar adenocarcinoma and one case of pure ductal adenocarcinoma. The pure form had a favorable histological differentiation, while the mixed forms had intermediate histological differentiation patterns. Invasiveness was related to both volume and histological differentiation. The finding of prostatic ductal adenocarcinomas among autopsy material, as well as some of their histological features, suggest that these tumors might have a similar biological potential as prostatic acinar cancer. 相似文献
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B Alevizos M Spengos D Vassilopoulos C Stefanis 《Journal of the neurological sciences》1976,28(2):225-231
gamma-Glutamyl transpeptidase, a membrane-bound enzyme playing an important role in the active amino acid transport across cellular membranes, is shown to be elevated in the serum of patients with myotonic muscular dystrophy. No increase of AP, LAP, GOT and GPT activities in the sera of some of the patients studied is observed. Possible interpretations in relation to the pathogenesis of myotonic dystrophy are discussed. 相似文献
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Respiratory pumping in Aplysia consists of transient, synchronous pumping actions of the gill, siphon, mantle shelf, and parapodia. This behavior has previously been shown to be driven by a network of coupled interneurons in the abdominal ganglion, the R25 and the L25 cells. We describe here a pair of electrically coupled cells, the R20 cells, which when active can initiate respiratory pumping or increase its spontaneous rate of occurrence. This action is mediated by a slow, long-lasting excitation of the endogenous burst mechanism of the cells in the R25/L25 network. The R20 cells, which are located in the abdominal ganglion, also make slow inhibitory connections to the RB cells and to the RG cells in that ganglion, and to the gill motoneurons in the branchial ganglion. The R20 cells are immunoreactive to SCPB, a molluscan neuropeptide. Biochemical purification studies demonstrate that each of the R20 cells synthesizes not only SCPB, but also SCPA, a closely related molecule known to be encoded by the same gene as SCPB. The R20 cells also synthesize in abundance several other low-molecular-weight, methionine-containing peptides. The excitatory actions of the R20 cells on the R25/L25 network are mimicked by SCPA and SCPB. However, the inhibitory actions of the R20 cells on the RB cells, the RG cells, and on the cells of the branchial ganglion are not mimicked by the SCPs. Thus, the data support the hypothesis that the R20 cells release SCPA and SCPB and at least one other unidentified transmitter. 相似文献