慢性荨麻疹和肝炎病毒感染的相关性研究进展

荨麻疹病因复杂，多种多样。近年来发现肝炎病毒感染不仅可以引起肝细胞的损伤，也可以引起肝外组织的损伤和相关症状，特别是乙型和丙型肝炎病毒感染，他们与慢性荨麻疹的发病也存在一定联系。本文的目的是系统的分析近年来国内外报道的慢性荨麻疹与乙型肝炎病毒及丙型肝炎病毒感染的相关性研究。通过临床表现和皮肤病理、皮肤免疫病理方面的调查研究，认为肝炎病毒感染，特别是乙型和丙型肝炎病毒感染，可能引起免疫复合物介导的肝外组织的损伤与免疫反应，与慢性荨麻疹的发生发展有相关性。     

微创皮下浅表刮吸法治疗腋臭方法的改良和疗效分析

目的：探索一种微创治疗腋臭的新方法。方法：观察121例采用皮下浅表刮吸法治疗腋臭患者的疗效和不良反应。结果：术后随访3个月～1年,121例中,114例患者在出汗时未闻到明显的异味,对治疗效果表示满意,满意率为94.2%,有效率达100%。对7例（5.8%）仍觉有轻度异味患者,4例行腋部激光脱毛治疗达到满意疗效,3例采用同样方法再次手术治疗达到满意效果。结论：肿胀麻醉下微创皮下浅表刮吸法治疗腋臭切口小、损伤轻、术后恢复快、疗效确切,值得推广。     

慢性荨麻疹与乙型肝炎病毒感染的关系

目的了解慢性荨麻疹与乙型肝炎病毒（HBV）感染的关系。方法检测150例慢性荨麻疹患者（病例组）HBV感染状况。并与100名正常人（对照组）进行比较,分析伴有HBV感染慢性荨麻疹的临床表现特点。结果HBsAg阳性率病例组为19．3％、对照组为10．0％,病例组HBsAg阳性率明显高于对照组（PearsonX2=3．970,P〈0．05）;病例组中HBsAg阳性者与阴性者之间病程、风团大小比较有统计学差异（P〈0.05）。结论慢性荨麻疹发病与HBV感染有一定关系。慢性荨麻疹伴有HBV感染者临床上病程较长、风团面积较大。     

纳米技术在光动力治疗恶性肿瘤中的应用前景

本文重点综述纳米颗粒技术在光动力学治疗中的应用,特别是对肿瘤治疗方面的应用前景.笔者分别从自发光纳米颗粒、自发光光动力疗法、纳米颗粒载体等方面进行阐述.     

慢性荨麻疹和肝炎病毒感染的相关性研究进展

荨麻疹病因复杂,多种多样。近年来发现肝炎病毒感染不仅可以引起肝细胞的损伤,也可以引起肝外组织的损伤和相关症状,特别是乙型和丙型肝炎病毒感染,他们与慢性荨麻疹的发病也存在一定联系。本文的目的是系统的分析近年来国内外报道的慢性荨麻疹与乙型肝炎病毒及丙型肝炎病毒感染的相关性研究。通过临床表现和皮肤病理、皮肤免疫病理方面的调查研究,认为肝炎病毒感染,特别是乙型和丙型肝炎病毒感染,可能引起免疫复合物介导的肝外组织的损伤与免疫反应,与慢性荨麻疹的发生发展有相关性。     

A comparative study on the enhancement efficacy of specific and non-specific iron chelators for protoporphyrin IX production and photosensitization in HaCat cells

The iron chelators can be utilized in target cells to improve 5-aminolaevulinic acid （ALA）-based photodynamic therapy （PDT）. The purpose of this study is to compare the effect of two kinds of iron chelators, desferrioxamine （DFO） and ethylenediaminetetraacetic acid （EDTA） on the enhancement of ALA-PDT. HaCat cells were cultured in medium containing 2.0 mmol/L of ALA and 0.5 mmol/L of DFO or EDTA. After 3-h incubation in the dark, the concentration of cellular pro-toporphyrin Ⅸ （PpⅨ） was detected by high performance liquid chromatography （HPLC）, and the fluorescence of PpⅨ was observed at 630 nm emission under confocal laser scanning microscope. For PDT, HaCat cells were irradiated using 632.8 nm laser, and the fractions of apoptotic and necrotic cells were flow cytometrically assayed. Related differences in morphology and ultrastructure of Ha-Cat cells were observed using optical microscope or transmission electron microscope. Compared to incubation with ALA alone, the addition of DFO or EDTA increased the concentration of cellular PpⅨ and the fluorescent density of PpⅨ, and also increased cell death ratio after PDT. PDT using ALA plus DFO produced the highest cellular PpⅨ level, greatest cell death ratio and most severe structural damage to the cells. It was concluded that both DFO and EDTA could enhance ALA-based PpⅨ production and PDT. Compared to the non-specific iron chelator of EDTA, the specific chelator, DFO, showed more potential for the enhancement.