复发性口疮患者超氧化物歧化酶的临床研究

Activity of superoxide dismutase (SOD) was determined in erythrocytes obtained from 74 patients with recurrent aphthous ulcerations (RAU) and 100 healthy individuals. The results showed that activity level of SOD in RAU was significantly lower as compared with that in the controls (P less than 0.01). The activity of SOD in 30 cases of RAU at interval period was elevated on reexamination, but it was still lower than that in the controls (P less than 0.01). There is evidence that damage of superoxide radicals (O.2) and decrease of activity of SOD may play important roles in the pathogenesis of RAU. A random double-blind, placebo-controlled, cross-over trial on membrane SOD was carried out in 40 patients with RAU. The results demonstrated that the effective rate of SOD was 90%, being markedly higher than that of placebo. It is suggested that membrane SOD, as a topical medicine, could increase the concentration of SOD on the ulcerous surfaces, prevent O.2-induced injury, decrease capillary permeability, relieve inflammation and improve cure of ulcer.     

复发性口疮患者超氧化物岐化酶的临床研究

本文对74名RAU患者和100名健康人作了血液SOD活性测定。结果显示患者的SOD活性较正常人明显降低(P<0.01),对30名患者在间歇期进行复查,发现SOD活性虽有回升,但仍低于正常人(P<0.01)。说明超氧自由基损伤及SOD活性的下降在RAU的发病机制中起重要作用。对40名口疮患者使用SOD药膜及安慰剂膜。通过自身交叉试验观察疗效。结果表明,SOD药膜的有效率为90％,明显优于安慰剂。其作用机理可能为患者贴药膜后,病损区局部的SOD浓度增高,可有效地清除病损区大量的O_2~(?),降低了血管的通透性,减轻炎症反应,减少组织损伤,从而加速了组织的愈合、     

复发性口疮患者超氧化物歧化酶的临床研究

作者对74名复发性口疮(RAU)患者和100名健康人作血液超氧化物歧化酶(SOD)活性测定,分别为779.6±198.8和418.3±205.6(P<0.01)。对30名患者在间隙期进行复查,发现SOD虽有回升,但仍低于正常人。对40名口疮患者使用SOD药膜及安慰膜,通过自身交叉试验观察疗效,结果:SOD药膜的有效率为90％,明显优于安慰剂。其作用机理可能为有效地清除了病损区大量的超氧自由基,从而加速了组织的愈合。     

银耳制剂对急性放射病犬的治疗效果

银耳制剂对~(60)Coy线全身致死剂量照射犬具有明显的治疗作用。动物照射后6、24、48小时肌注银耳制剂15毫克/公斤,可提高经300和320拉德照射犬的活存率56.9％及30.8％。治疗动物病情减轻,活存时间明显延长,外周血白细胞数高于对照犬。对银耳制剂治疗放射病的作用机制进行了讨论。