排序方式: 共有13条查询结果,搜索用时 0 毫秒
1.
2.
1978~1989年在食管癌高发现场用复合核黄素对食管上皮重度增生患者进行阻断治疗,约2年吞(拉)网细胞学随诊一次,共6次。本文报告137例效果评价分析。第6年时与对照组比较,两组好转率分别为47.2%(42/89)及20%(7/35),进展率为19.1%(17/89)和42.9%(15/35),癌变率为1.1%(1/89)及14.3%(5/35),两组间差别均有显著性(P<0.025)。治疗组第12年好转率为46.6%(34/73),癌变率为5.5%(4/73)。12年中累计发现癌患者8例,占5.8%。远低于文献回顾调查1~12年的自然癌变率(14.9%,79/530)。 相似文献
3.
早期食管原发性腺癌初步病理分析 总被引:3,自引:0,他引:3
通过7例早期食管原发性腺癌手术标本系列大切片的观察,证明在早期食管癌中确有原发性腺癌存在。患者平均年龄46岁,较中晚期癌患者年轻约10岁。病理类型以浅表缺损型为主,癌灶平均长度13mm。病理特征为:(1)癌变多起始于食管固有腺腺管上段,可在相邻数个腺体内同时发生;(2)组织学上多表现为腺管癌;(3)癌灶表面和周围覆盖有受压变薄或呈增生性改变的鳞状上皮;(4)多伴有鳞癌成分。 相似文献
4.
5.
应用扫描电镜技术观察了22例在河南林县取材的食管拉网涂片中,经光镜定性、定位的正常、轻度增生、重度增生Ⅰ级、重度增生Ⅱ级、近癌和癌变鳞状上皮细胞的表面超微结构的变化。发现从正常到近癌阶段细胞间嵴由清晰渐至消失,微嵴渐增多致密,由正常的条纹状平行排列逐渐变为不规则的螺纹、漩涡和线团状排列。癌细胞形态不规则、细胞明显增厚、微嵴及间嵴消失,与正常和增生细胞明显不同。文内还讨论了各级细胞表面结构与分化和代谢变化的关系。 相似文献
6.
7.
On cytosmears of esophageal epithelium of individuals from high-risk area of esophageal cancer squamous epithelial cells, according to standard cytologic diagnostic criteria, can be categorized as normal, hyperplasia, severely dysplastic grade I and grade II, nearly-carcinoma and early carcinoma. Cytosmears from 60 patients, 10 for each category, were studied with a semiautomatic image analysis system. Thirteen morphologic parameters so obtained were further analyzed by computer-based stepwise regression and linear correlation analyses. The results showed that the following 5 parameters could be used to judge the nature of the cells, i.e. a) cytoplasmic area, b) cytoplasmic mean diameter, c) cytoplasmic form factor, d) nuclear form factor and e) N/C ratio. Comparing with cells of the other categories, values of the first 4 parameters for early cancer cells were decreased whereas that of the fifth parameter was significantly increased. From normal to hyperplastic and to dysplastic cells, the nuclear area and mean nuclear diameter were gradually increasing. Therefore, they were the major parameters in judging the degree of hyperplasia and dysplasia. These numerical features of morphologic quantitation conformed with the cytologic diagnostic criteria for cancer, hyperplasia and dysplasia under light microscope. It indicates that visual judgement is relatively accurate and application of the ocular micrometer to measure the cells would make this grading more objective. 相似文献
8.
9.
10.
The relative DNA contents of normal esophageal squamous epithelial cells, hyperplastic, dysplastic (grade I and II), nearly malignant and early malignant squamous epithelial cells of the esophagus were measured in 74 cases by microspectrophotometric technique. The results showed that from normal cells to early stage of malignancy, the DNA contents gradually increased with the increase in severity. In addition, the distribution of DNA values became broader; the peak DNA values shifted to the right, reduced and disappeared. In the meantime, aneuploid cells appeared. There was a definite positive correlation between DNA content and nuclear area in precancerous dysplasia (r greater than 0.9). The results indicate that the current grading of esophageal cytology has its quantitative biochemical basis. 相似文献