不同类型心房颤动患者心脏结构及B型钠尿肽水平的变化

Objective: To analyze the risk factors related to plasma levels of BNP in patients with different types of atrial fibrillation（AF）. Methods:Sixty-five patients with AF were divided into paroxysmal AF group (n=35) and persistent AF group (n=30), and 30 patients without AF were included as control. Detailed information were recorded including the basic characteristics of patients, biochemical parameters, the levels of plasma BNP and transthoracic echocardiography indices. Results: The BNP level in patients with persistent AFgroup was significantly higher than that in paroxysmal AF group (BNP:397.70 ± 335.91vs215.17 ± 212.66,P<0.001), and the BNP level in the two groups with AF was higher than control group (63.93 ± 69.78, P <0.001). The blood BNP levels were positively correlated with LAD (r=0.419, P <0.001). Conclusion: The plasma BNP levels tend to increase with the development of atrial fibrillation, and are significantly positively correlated with LAD in patients with atrial fibrillation.     

吡拉西坦与脑苷肌肽治疗急性脑出血水肿分析

目的评价联合治疗(吡拉西坦、脑苷肌肽)急性脑出血伴脑水肿患者的影响,为急性脑出血伴脑水肿患者的临床用药提供参考。方法选择医院2018年4月-2019年10月收治治疗的急性脑出血伴脑水肿患者(n=96),进行相应手术治疗的基础上随机分组(试验1组、试验2组),试验1组采取吡拉西坦联合脑苷肌肽治疗,试验2组采取吡拉西坦治疗。对比试验1组与试验2组急性脑出血伴脑水肿患者治疗后临床疗效等情况。结果试验1组治疗总有效率高于试验2组,治疗后日常生活能力、认知功能、神经功能缺损、血清学指标水平对比试验1组优势明显,P<0.05。结论针对急性脑出血伴脑水肿患者,行吡拉西坦联合脑苷肌肽治疗预后效果更佳,促进患者症状体征改善。     

不同类型心房颤动患者心房钠尿肽水平及相关因素研究

目的：比较不同类型心房颤动（artial fibrillation, AF）患者血浆心房钠尿肽（atrial natriuretic peptide, ANP）水平的差异,分析影响患者血浆ANP水平的相关因素。方法：入选35名阵发性AF患者、30名持续性AF患者和30名非AF患者为研究对象。详细记录患者基线资料、生化指标及经胸超声心动图检查（the thoracic echocardiography,TTE）等指标,测定血浆ANP水平,分析ANP水平与心率、超声指标的关联,明确AF发作或持续时间与ANP水平的关系。结果：AF患者ANP水平明显高于非AF患者（P<0.05）,与AF时心率正相关（r=0.386,P=0.000）。阵发性AF患者AF时ANP水平显著高于窦性心律时（t=4.040,P=0.001）,且与AF持续时间明显正相关（r=0.742,P=0.000）;而持续性AF患者ANP水平与AF持续时间未见明显相关性（r=0.386,P=0.000）。持续性AF患者左心房内径（left atrial diameter,LAD）、右心室舒张末期内径（right ventricular end diastolic diameter,RVDd）明显高于阵发性AF（P=0.000 vs. P=0.013）和非AF（P=0.000 vs. P=0.023）患者;阵发性AF患者LAD亦明显高于非AF患者（P=0.000）。但未见ANP水平与超声指标间存在明显相关性（P>0.05）。结论：AF患者血浆ANP水平升高,且ANP水平与AF时心率、持续时间等因素相关,与AF类型、超声指标不相关。