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1.
The most outstanding pathological changes of perinatal babies and children, based on the review of the autopsy files in the 1st Affiliated Hospital of West China University of Medical Sciences, are lymphocytic depletion, and reticuloepithelial cell swelling and/or fusiform malformation in the cortex, while in the medulla apoptosis is more prominent. We suppose that these alterations are due to immaturity of cortical thymocytes, and in the diseased condition, they are easily affected by extraordinary factors, especially the influence of corticosterone inducing acute severe necrosis, so the number of lymphocytes are obviously diminished. But, in the medulla, as intact mature lymphocytes exist, physiological phenomenon such as apoptosis is rather prominent in it. While in the medulla, Hassall's corpuscles have various characteristic changes, such as cornification, calcification, fusion, cystic change and disintegration. Besides, we observed a new alteration in the thymus defined as vacuolization. All the above pathological changes reached the peak in the 28- day group; there after, they might become either worse or better according to the condition of the disease and growth of the body. However, these are still problems to be further studied separately. 相似文献
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骨性纤维发育异常--好发于儿童的新病种 总被引:4,自引:0,他引:4
目的:为了提高骨性纤维发育异常的诊断水平,避免治疗失误及降低复发率。方法:通过35例长骨纤维性骨病变的复查,并加用特殊染色观察组织病变,发现本病10例,平均年龄6.7岁。全部经手术刮除病灶。结果:6例获1~9年随访,5例术后1~2年内复发,复发率高达83%,其中2例分别于术后5年和8年自愈。结论:综合临床、X线以及病理资料已足以将本病和单骨性纤维结构不良等病区别开来成为一个新的病种。本病预后良好,因手术年龄愈小,术后复发率愈高,故手术不宜在10岁以下进行。 相似文献
3.
对73例胃肠道平滑肌肿瘤的病理改变与预后的关系的研究结果表明:核分裂相数是估计该肿瘤良、恶性程度及预后的最好指标。0个/10HPF为良性,1~9个/10HPF为低度恶性,≥10个/10HPF为高度恶性;在易查见核分裂相的肿瘤中,直径>6cm者较<6cm者预后差。免疫组化染色,结蛋白阳性率为43.83%。电镜观察,5例中3例查见向平滑肌分化的证据。文内还对该肿瘤的组织起源进行了探讨。 相似文献
4.
为了把七年制医学生培养成有创新能力的高层次医学人才,华西临床医学院病理教研室在对2002级七年制病理学教学中,采取了要求学生撰写读书报告的教学方式,较早地训练了学生检索文献、阅读文献、理解及评价文献等方面的能力.结果表明,该教学方法取得了较好的教学效果,若稍加改进,可在今后的七年制病理学教学中推广. 相似文献
5.
通过对584例儿童尸检胸腺的研究,发现各种病因对任何年龄儿童均可导致胸腺不同程度的退化,轻者仅见其皮质淋巴细胞轻度减少,重者皮质淋巴细胞大量减少,皮髓质分界不清,小叶体积缩小。影响胸腺退化程度的因素,除与病程有关外,主要是病因。病因中生物性因子较非生物性因子所致为重,和患肿瘤时相似。胸腺小叶体积缩小主要与病程有关,患肿瘤时小叶体积也易缩小。作者提出,对小儿所患疾病应进行病因治疗,以缩短病程,避免胸腺重度退化。 相似文献
6.
阿霉素诱发大鼠肾病模型的实验研究 总被引:15,自引:0,他引:15
A single intravenous injection of adriamycin (5 mg/kg) into rats caused the full expression of nephrotic syndrome characterized by heavy proteinuria, hypoalbuminemia, hypercholesterolemia, thoracic and ascitic fluid; swelling and fusion of foot processes of epithelial cells could be observed under electron microscope; histologic examination by light microscopy did not reveal any significant changes. The features of the model in clinic and pathology were very similar to those described humans with minimal change nephrotic syndrome. The observation in the various periods of the model indicated that the ultrastructure changes in epithelial cells occurred prior to the onset of proteinuria. The present study, combined with the results of quantitative analysis with image analyzer for alteration of glomerular polyanions, suggests that both morphologic changes and proteinuria may be the consequence of a common primary event that is the loss of glomerular polyanions. The model has the advantages of being rather simple and convenient; providing lasting proteinuria and pathological changes in stable condition; and having high reproducibility and a sufficient supply of the drug used. 相似文献
7.
肾小体的体视学研究方法 总被引:1,自引:0,他引:1
体视学用于定量研究肾小体形态结构仅有二、三十年的历史,现已成为肾小体研究中最有价值的定量分析技术。本文概述了研究肾小体的常用体视学参数及其测试方法,并就其中一些值得注意的问题进行了讨论。 相似文献
8.
作者报告了441例小儿畸形尸检病例。尸检畸形总检出率为12.03%,其中围产儿尸检畸形检出率(48.43%)是非围产儿(9.21%)的两倍(P<0.005%),年龄愈小,畸形愈多。不同年代的畸形检出率波动较大。系统畸形与疾病畸形均以心血管系统为主,占31%以上,其次为消化系统,再次为神经系统。此外,就畸形对婴儿和儿童生长发育的影响,及畸形与死亡的关系进行了简单讨论。 相似文献
9.
儿童胸腺退化的形态变化及临床意义 总被引:1,自引:0,他引:1
通过584例儿童胸腺研究发现任何年龄的儿童各种病因都可导致胸腺退化。影响退化程度的因素,主要为病因。生物性因子所致退化较非生物性因子所致的重。胸腺小叶体积缩小主要与病程有关。作者提出,应针对患儿所患疾病的病因进行治疗,以缩短病程,避免胸腺重度退化塌陷,有利于结构和功能恢复。 相似文献
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注射性臀肌挛缩是累及儿童的一种疾患;常致行走障碍。患儿在幼年时多有较长期的臀部肌肉注射青霉素(以下称PNC)等药物史。为了探讨其发病是否与注射药物有关,本院小儿科成功地建立了注射性肌挛缩动物模型。在此基础上,我们进行了病理学观察,现将结果报道于下。 相似文献