丁苯酞预处理对缺血再灌注大鼠脑组织抗氧化能力的影响

脑梗死等临床常见缺血性脑血管病严重危害人类健康。开展对这类疾病的研究和防治是目前一项重要任务,药物预处理防治脑缺血再灌注损伤已成为目前研究的热点。近年研究发现,丁苯酞（dl-3n-butylphthalide,NBP）能够从多个环节改善脑缺血性损伤,对缺血性卒中具有较佳的治疗作用。但目前关于应用NBP对脑缺血再灌注损伤预防性保护作用的报道较少。本研究应用NBP预处理大鼠,观测神经功能评分和SOD、GSH-Px活性及MDA含量的变化,探讨NBP对大鼠脑缺血再灌注抗氧化能力的影响及可能机制。     

承德市四所高校教师亚健康现况调查

亚健康(sub-health)已被医学界称为21世纪人类健康的最大威胁之一。随着社会的发展,亚健康所困扰的主体人群在知识分子中有增加趋势,尤其是高校教师已成为亚健康的高发人群[1]。为了解承德市高校教师亚健康现状及主要影响因素,为有效防治教师亚健康提供依据,2011年11月,本科研小组对承德地区高校教师的亚健康状况进行了现况调查。1对象与方法     

富血小板血浆促进牵拉成骨的矿化过程

BACKGROUND: The platelet-rich plasma contains various growth factors that could enhance the regeneration of certain tissues. OBJECTIVE: To observe the effect of platelet-rich plasma on the mineralization process during distraction osteogenesis in rabbits. METHODS: Thirty-two adult Japanese white rabbits were randomly divided into four groups (n=8 per group). The upper 1/3 tibial osteotomy at the posterior limb was performed in all rabbits, and the 1 cm limb lengthening models were prepared, followed by the local injection of 500 μL platelet-rich plasma at 5, 15 and 25 days. The controls received no treatment. At 37 days after modeling, the rabbits were killed and newly formed callus was removed to undergo hematoxylin-eosin staining, and the frontal X-ray film of tibia was obtained. RESULTS AND CONCLUSION: Lane-Sandhu radiographic scoring showed that the scores in the injection groups at 15 and 25 days after modeling were obviously better than those in the control group and the injection at 5 days after modeling. Lane-Sandhu histological scoring revealed that the scores in the injected groups at 15 and 25 days after modeling were significantly higher than those in the control group and group at 5 days after modeling (P < 0.05), which highest at 25 days. These results suggest that local injection of platelet-rich plasma can promote bone mineralization during distraction osteogenesis effectively, especially in the middle period of distraction osteogenesis. 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程