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Effect of general anaesthesia with combination of acupuncture and enflurane applied in radical operation of laryngocarcinoma
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Objective: To observe the effect of general anaesthesia with combination of acupuncture [ conducted with Han's acupoint nerve stimulator (HANS) applied] and enflurane in radical operation of laryngocarcinoma (LC). Methods: Sixty patients with LC of grade Ⅰ -Ⅱ, classified according to the standard of American Society of Anesthesiologists (ASA), were assigned by randomizing number table to the control group and the tested group, 30 patients in each group. The control group received anaesthesia with enflurane alone for inducing and maintaining; the tested group was anaesthetized with enflurane like that given to the control group but also received additionally needling stimulation conducted by HANS. The dosage of enflurane used, the minimum effective concentration of enflurane in alveolar air (MACEnf) and the changes of heart rate (HR) as well as blood pressure (BP) in patients at different time points in the operational process were observed. Results: As compared with those in the control group, in the tested group, both the MACEnf and the dosage of enflurane were reduced, with the difference between the two groups significant ( P〈0.01 ). The changes of HR and BP among different time points in the tested group were slight, and as compared with those in the control group at the corresponding time points, the difference was significant ( P〈 0. 05 or P〈0.01). Conclusion: General anaesthesia with combination of enflurane and needling conducted by HANS applied in radical operation of LC has definite effect with less complication. Needling could be cooperated with narcotics, and so it could be taken as an auxiliary measure of anaesthesia for radical operation of LC. 相似文献
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目的 探讨布托啡诺与盐酸左布比卡因在小儿骶管麻醉中的应用效果.方法 60例ASA Ⅰ~Ⅱ级择期行脐平面以下手术的患儿,均施行骶管麻醉,分为3组,骶管麻醉用药:0.25%盐酸左布比卡因注射液1 ml/kg(组Ⅰ),25 μg/kg布托啡诺用生理盐水稀释成1 ml/kg(组Ⅱ),25μg/kg布托啡诺和0.25%盐酸左布比卡因混合液1 ml/kg(组Ⅲ).术中静脉泵注丙泊酚辅助麻醉.术中监测心率、血压和呼吸,记录术中镇痛镇静药物用量和镇静评分、麻醉时效、术后苏醒时间、术后镇静、镇痛评分以及术后并发症等.结果 与组Ⅰ和组Ⅱ比较,组Ⅲ患儿术中丙泊酚用量显著降低,而镇静评分显著升高,苏醒时间明显缩短,麻醉时效显著延长,在术后组Ⅲ患儿镇痛评分显著低于其余两组,而术后镇静评分和麻醉并发症三组间差异无统计学意义(P〉0.05).结论 盐酸左布比卡因复合布托啡诺用于小儿骶管麻醉可显著减少术中镇静药物用量,延长麻醉效果,具有有效的术后镇痛作用,并减少呼吸抑制等不良反应,是一种安全、有效的小儿骶管麻醉方法. 相似文献
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目的探讨抗凝血酶对Stanford B型主动脉夹层覆膜支架植入术患者炎性细胞因子和粘附分子的影响及临床意义。方法拟行覆膜支架植入术的Stanford B型主动脉夹层患者40例,随机分为两组各20例。治疗组术中肝素化前和肝素化后24 h输注抗凝血酶3 000 U,大于30 min输完;对照组为空白对照组。分别于手术前和手术后即刻、手术后1 d和2 d采动脉血标本,检测血浆肿瘤坏死因子α(TNF α)、白细胞介素1(IL 1)、IL 6、IL 8和细胞间粘附分子1(ICAM 1)、内皮白细胞粘附分子1(ELAM 1)和血管细胞粘附分子1(VCAM 1)含量变化。结果对照组术后2 d ICAM 1从术前(194.25±42.32) ng8226;mL-1升至(268.64±22.09) ng8226;mL-1,治疗组从术前(194.22±41.42) ng8226;mL-1降至(115.03±24.11) ng8226;mL-1,两组术后2 d差异有统计学意义(P<0.01);两组术后IL 1、IL 6、IL 8、TNF α、VCAM 1和ELAM 1均有升高趋势,但治疗组升高幅度显著低于对照组,差异有统计学意义(P<0.01或P<0.05)。结论Stanford B型主动脉夹层覆膜支架植入术患者炎性反应激活,表现为大量炎性因子释放和粘附分子表达,而抗凝血酶能降减低机体高炎性反应状态,预防术后不良反应。 相似文献
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韩氏穴位神经刺激仪对甲状腺术后的影响 总被引:2,自引:0,他引:2
目的观察应用韩氏穴位神经刺激仪(HANS)对甲状腺手术病人术后循环和疼痛的影响。方法选择100例ASAⅠ。Ⅱ级拟行甲状腺部分切除术病人,随机分为A、B两组,每组各50例。均采用C4一针法进行双侧颈浅神经丛及患侧颈深神经丛阻滞,所用药物为0.35%罗哌卡因。A组为单纯颈神经丛阻滞组(对照组);B组为颈神经丛阻滞辅以穴位粘电极HANS组,颈神经丛阻滞前使用HANS刺激20min,术中持续刺激,并且在术后4、8、12h再行电针刺激3次,每次20min。结幂B组术后心率、血压、血氧饱和度各项生理指征平稳,疼痛及恶心呕吐评分与A组相比有统计学差异。术后使用镇痛药的病人例数明显少于A组。结论甲状腺手术病人应用韩氏穴位神经刺激仪,可减轻术后疼痛,保持术后循环稳定。 相似文献
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摘要 目的 观察臭氧对膝骨性关节炎患者关节腔滑液和血浆中肿瘤坏死因子(TNF) α、白细胞介素(IL)-1和基质金属蛋白酶(MMP)-1的影响,探讨医用臭氧治疗膝骨性关节炎的机制。方法膝骨性关节炎患者60例,随机分为3组,分别为臭氧组(Ⅰ组)、消炎镇痛液组(Ⅱ组)和臭氧+消炎镇痛液组(Ⅲ组),每组20例。Ⅰ组膝关节内注射30 μg·mL-1臭氧30 mL;Ⅱ组膝关节内注射2.5 mg·mL-1维生素B6+0.1 mg·mL-1甲钴胺+1%利多卡因10 mL;Ⅲ组膝关节内注入消炎镇痛液同Ⅱ组,并于5 min后再注入30 μg·mL-1臭氧30 mL。每周2次,共注射3周为1个疗程。治疗前和治疗1个疗程后采外周静脉血和治疗侧膝关节滑液,检测TNF α、IL 1和MMP 1的含量。结果1个疗程结束后,患者关节滑液TNF α、IL 1和MMP 1的含量在Ⅰ组分别为(43.21±3.55),(23.69±2.12)和(87.47±6.84) pg·mL-1;在Ⅱ组分别为( 89.56±7.06),(54.66±4.89)和(369.65±15.35) pg·mL-1;在Ⅲ组分别为( 42.25±7.11),(19.44±5.09)和(75.96±8.25) pg·mL-1。3项指标在Ⅰ组和Ⅲ组治疗后均显著低于Ⅱ组,差异有统计学意义(P<0.05或P<0.01);且3项指标在Ⅰ组和Ⅲ组治疗后均显著低于治疗前(P<0.05或P<0.01),而在Ⅱ组治疗前后的变化不明显。3组中血浆TNF α、IL 1和MMP 1的含量治疗后虽均有下降趋势,但3组间无明显差异,且与治疗前比较也均差异无统计学意义(P>0.05)。结论膝骨性关节炎患者关节内注射臭氧可抑制关节腔和血浆内炎性因子的释放,减轻关节炎的炎性反应,这可能是医用臭氧有效治疗膝关节炎的作用机制之一。但关节腔注射对全身的炎性反应影响不明显。 相似文献
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