食管125I粒子支架姑息治疗晚期食管癌剂量学参数与疗效的关系

目的观察食管¹²⁵I粒子支架姑息治疗Ⅲ~Ⅳ级吞咽困难初治食管癌患者的疗效,分析剂量学参数与预后的关系。 方法采用食管¹²⁵I粒子支架置入姑息治疗吞咽困难食管癌患者28例。粒子活度0.4～0.8 mCi,术前处方剂量60～80 Gy。术后行CT扫描并行剂量验证,评估90%、100%肿瘤体积接受的处方剂量(D90、D100)、计划靶区接受90%、100%处方剂量的体积百分比(V90、V100)。按照粒子活度将患者分为低中活度组和高活度组,按照D100将患者分为D100＜30 Gy组和D100≥30 Gy组,比较各组吞咽困难缓解维持时间、总生存期(OS),并分析其关系。 结果全组28例均成功完成支架植入,术后吞咽困难缓解维持时间为150天(95%CI 65～234),OS为173天(95%CI 66～280)。多因素分析提示,粒子低中活度组有吞咽困难缓解维持时间的优势(χ²=5.413,P＝0.020),术后D100≥30 Gy有吞咽困难缓解维持时间优势和生存优势(χ²=5.496/4.035,P＝0.019/0.045)。 结论食管¹²⁵I粒子支架姑息治疗晚期食管癌有效,低中剂量粒子活度0.4~0.6 mCi、术后D100≥30 Gy有利于提高患者吞咽困难缓解维持时间和总生存期。     

Correlation between increased circulating endothelial progenitor cells and stage of non-hodgkin lymphoma

This study aims to examine the levels of circulating endothelial progenitor cells (cEPCs) in the peripheral blood of patients with non-Hodgkin lymphoma (NHL) and their correlation with the tumor stage. Forty-one patients with biopsy-proven NHL and 16 healthy individuals were recruited. Peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation, and cEPCs were characterized by triple staining using antibodies against CD133, CD34 and vascular endothelial growth factor receptor-2 (VEGFR-2, CD309) and quantified by flow cytometry. In NHL patients, the number of cEPCs was significantly greater than in control group (P=0.000). The cEPCs counts in patients with NHL of stage Ⅲ-Ⅳ were significantly greater than in stage Ⅰ-Ⅱ (P=0.010). FACS analysis revealed that the number of cEPCs in NHL patients had no correlation with the gender (P=0.401) or the pathological category (P=0.852). It was suggested that the over-expression of cEPCs in NHL patients may serve as a novel biomarker for disease progression in NHL.     

食管125I粒子支架姑息治疗晚期食管癌剂量学参数与疗效的关系

目的 观察食管125I粒子支架姑息治疗Ⅲ～Ⅳ级吞咽困难初治食管癌患者的疗效,分析剂量学参数与预后的关系.方法 采用食管125I粒子支架置入姑息治疗吞咽困难食管癌患者28例.粒子活度0.4～0.8 mCi,术前处方剂量60～80 Gy.术后行CT扫描并行剂量验证,评估90％、100％肿瘤体积接受的处方剂量(D90、D10...     

细菌木聚糖酶粗酶的提取及性质的研究

在 2 0℃条件下 ,采用相对饱和度为 50 %的 (NH4) 2 SO4一步盐析并经 4 5～ 50℃烘干 1 0h得到木聚糖酶粗酶粉 .初步研究了该酶的一些基本性质 ,结果表明 ,该酶在 55℃下 ,pH值为 4 .6～1 0 .5之间较稳定 .最适作用温度与 pH值分别为 50℃和 7.6.该粗酶产品适合造纸工业的纸浆处理 .