Graves病硫脲类药物治疗所致甲减（附32例临床分析）

Ｇｒａｖｅｓ病硫脲类药物治疗所致甲减（附３２例临床分析）广东省广宁县人民医院内科（５２６３００）梁如庆广州军区广州总医院内分泌科王国华，林延德Ｇｒａｖｅｓ病（弥漫性甲状腺肿伴甲状腺功能亢进症）的治疗方面，鉴于多数患者对手术有顾虑，同位素碘治疗尚不能普...     

载脂蛋白E基因多态性与脑梗死的相关性分析

目的　探讨载脂蛋白 E基因多态性与脑梗死的关系。方法　通过聚合酶链反应 -限制性片段长度多态性 (PCR- RFL P)分析结合 DNA直接银染技术检测 6 6例脑梗死 (CI)患者的载脂蛋白 E(Apo E)基因型 (其中家系中有明确脑梗死先证者的家族聚集性脑梗死 (FMACI)亚组 2 6例 ,家系中无脑卒中史的非家族聚集性脑梗死 (NF-MACI)亚组 4 0例 ) ,并与 90例健康对照组比较 ,同时检测血脂、脂蛋白 (a) [L P(a) ]及部分载脂蛋白。结果　脑梗死组ε3/4基因型频率明显高于对照组 (P<0 .0 1) ,ε3/3基因型频率明显低于对照组 (P<0 .0 1) ;两脑梗死亚组之间的ε3/4/ε3/3基因型频率虽有上升 /下降趋势 ,但未发现明显的统计学差异 ;FMACI组高密度脂蛋白 (HDL )水平明显低于 NFMACI组 (P<0 .0 5 )。结论　 Apo E基因多态性与脑梗死的发生有关 ,ε4等位基因是脑梗死的易感因子 ,ε3等位基因对脑梗死的发生有保护作用 ;Apo E基因多态性和 HDL水平双重作用于家族聚集性脑梗死的发生。     

巩膜腔内硅胶球植入的临床研究(摘要)

我科在13例眼球摘除患者中应用改良的巩膜腔内硅胶球植入术的方法,装配义眼后,有一定活动度,患者容貌得到了满意的改善。报告如下。本组13例中男10例,女3例。年令10～60岁。眼球摘除原因:眼球萎缩6例,角膜葡萄肿2例,眼内炎4例,角膜瘘1例,材料选用国产硅橡胶球。常规行眼球内容物剜出术,将巩膜腔内处理干净后:(1)于巩膜缘3及9点处各做以缘为底的三角形切除;(2)植入硅胶球,丝线交叉贯穿硅胶球,缝合固定于巩膜内板层壁上,连续缝合巩膜;(3)交     

脂氧素A4对心肌缺血再灌注损伤的保护作用

Objective To investigate the roles of lipoxin A4, an endegenous lipid mediator with wide anti-inflammatory fea- tures, in attenuating myocardial ischemia-reperfusion injury and the possible mechanisms. Methods Thirty male KM mice were divid- ed randomly into three groups, 10 in each: ischemia-reperfusion group (group A), lipoxin A4 (0.1 mg/kg) group (group B) and Zn- PP (Zinc protoporphyrin Ⅸ, 25 mg/kg)phus lipoxin A4 (0.1 mg/kg)group (group C). A ischemia-reperfusion heart model was de- veloped by ligating the lift anterior descending branch of the coronary artery. A dine of 10% dehydrated alcohol in 0.2 ml for group A, a dose of isochoric lipoxin A4 for group B and a dose of isochoric ZnPP + lipoxin A4 for group C was infused into the ascending aorta through a catheter, which was kpassing the right common carotid artery, 30 minutes after reperfusion. The concentration of serum TNF-α, activities of serum crestine kinase(CK) and lactate dehydrogenase (LDH), activities of myeloperoxidase (MPO) and malond- ialdehyde (MDA) and the cell apoptosis rate in the myocardial tissue were measured 5 hours after reperfusion. Pathological features of the inflammatory infiltration in the myocardium were also observated.Results As compared with group A, the inflammatoryry infiltra- tion in the ischemic and necrotic regions tithe myocardium was reduced, with group C in the intermediate range. The serum activities of CK and LDH wine significantly lower in group B and C than that in group A, and the lowest activities were detected in group B. Similar findings were observed for MPO, an indicator for neutrophil infiltration, and MDA, an indictor for cell injury caused by oxy- gen radicals, in the myocardium. The concentration of TNF-α and the rate of cadiocyte apoptosis were decreased significantly in group B(P < 0.01). ZnPP, an inhibitor of heine oxygenase (HO)-1, attenusted the above protective effects of lipoxin A4 significantly (P<0.05). Conclusion Lipoxin A4 has protective effects against myocardial ischemia-reperfusion injury, and HO-1 may have a potential role in the protectve mechanisms of lipoxin A4, probably pertly by means of reducing the production of reactive oxygen spe- cies and TNF-α, decreasing the activation and infiltration of neutrophils, alleviating inflammatory damage and avoiding apoptosis.     

自制幼儿口垫在临床胃镜检查中的作用

近年来，幼儿将硬币、游戏机币、钮扣等小物件吞入食管、胃内的病例时有发生。行胃镜取幼儿食管及胃内异物时。建立口通道常有困难，市售口垫直径过大，难以放入幼儿口部且质地过硬，容易对幼儿口唇造成损害，再就是长度过短，不能压住幼儿舌体。笔者从2001年用自制口垫很好地解决了这些问题。     

老年人高血压性脑出血急性期T淋巴细胞亚群的检测及初步探讨

老年人高血压性脑出血急性期Ｔ淋巴细胞亚群的检测及初步探讨王国华，张秀华，白颖哈市第一医院神经科王文宝哈市第一医院血液病研究所祁威，方俊兰哈市第十医院神经科自从１９７９年Ｒｅｉｎｈｅｒｚ获得淋巴细胞单克隆抗体以来，使人们对Ｔ淋巴细胞亚群及其临床意义逐渐...     

一种治疗翼状胬肉的新术式

翼状胬肉治疗方法很多,却很难有效控制其复发。笔者采用彻底切除翼状胬肉根部的方法,治疗146例,经长期随访观察,效果满意。报告如下。对象与方法1.对象:本文以门诊及住院的翼状胬肉患者134人(146眼)为治疗观察对象。男93人,女41人。年龄18—74岁。双眼发病12     

脑肿瘤

在美国成人每年脑瘤的新发生数约35000人,这些脑瘤被分为二类:即原发于脑实质和脑膜的肿瘤以及起源于身体其它脏器的转移性脑瘤.每年死于恶性胶质瘤占癌症死亡人数的2.5％,且是15至34岁人群死于癌症的第二位原因.原发性脑瘤形成与环境因素之间无必然联系,但头部受到放射线或被某些化学物质侵袭,有可能使星形细胞瘤和脑膜瘤发生率增加,头颅外伤也可能诱发脑膜瘤。原发性脑瘤患者16％有癌症家族史。