Effects of IL-17 on expression of GRO-α and IL-8 in fibroblasts from nasal polyps

Recent studies indicated that interleukin（IL）-17, growth-related oncogene（GRO）-α and IL-8 play an important role in the pathogenesis of nasal polyps. However, the effects of the increased amount of IL-17 and the production of GRO-α and IL-8 in human nasal polyp fibroblasts are not completely understood. This study aimed to determine the effects of the increased IL-17 on the changes of GRO-α and IL-8 expression in human nasal polyp fibroblasts and further investigate the mechanism of neutrophil infiltration in nasal polyps. Nasal polyp fibroblasts were isolated from six cases of human nasal polyps, and the cells were stimulated with five different concentrations of IL-17. Real-time fluorescence quantitative polymerase chain reaction（RT-PCR） was used to detect the mRNA expression of GRO-α and IL-8. The mRNA of GRO-α and IL-8 was expressed in unstimulated controls and remarkably increased by stimulation with IL-17. Moreover, the levels of GRO-α and IL-8 produced by fibroblasts were increased gradually with the increases in IL-17 concentrations. The present study showed that nasal fibroblasts can produce GRO-α and IL-8, and their production is remarkably enhanced by IL-17 stimulation, thereby clarifying the mechanism of the IL-17 mediated neutrophil infiltration in nasal polyps. These findings might provide a rationale for using IL-17 inhibitors as a treatment for nasal inflammatory diseases such as nasal polyps.     

耳廓大部断离伤的综合治疗

目的　探讨采用手术联合药物综合治疗耳廓大部断离伤的临床疗效。方法　回顾性分析2017年5月～2018年8月在我院诊治的耳廓大部断离伤患者7例,经彻底消毒清创后采用对位缝合、局部放置引流、敷料加压包扎,术后给予预防和控制感染、改善微循环联合高压氧的综合治疗措施,观察治疗效果。结果　术后耳廓外观及患者感觉均良好,无1例发生耳廓坏死,治疗效果满意。结论　经过该综合治疗方案,耳廓大部断离伤治愈效果好,成活率高,取得良好临床疗效,值得临床推广。     

难治性慢性鼻-鼻窦炎与细菌生物膜

慢性鼻-鼻窦炎（CRS）是鼻腔和鼻窦黏膜的慢性炎症,症状持续至少12周,是宿主和环境多因素相互作用的结果。CRS是耳鼻咽喉科的常见疾病,最近有报道指出美国CRS患病率大于16％,