Biomechanical behavior of brain injury caused by sticks using finite element model and Hybrid-III testing

Objective: To study the biomechanical mechanism of head injuries beaten with sticks, which is common in the battery or assaultive cases. Methods: In this study, the Hybrid-III anthropomorphic test device and finite element model (FEM) of the total human model for safety (THUMS) head were used to determine the biomechanical response of head while being beaten with different sticks. Total eight Hybrid-III tests and four finite element simulations were conducted. The contact force, resultant acceleration of head center of gravity, intracranial pressure and von Mises stress were calculated to determine the different biomechanical behavior of head with beaten by different sticks. Results: In Hybrid-III tests, the stick in each group demonstrated the similar kinematic behavior under the same loading condition. The peak values of the resultant acceleration for thick iron stick group, thin iron stick group, thick wooden stick group and thin wooden stick group were 203.4 g, 221.1 g, 170.5 g and 122.2 g respectively. In finite element simulations, positive intracranial pressure was initially observed in the frontal comparing with negative intracranial pressure in the contra-coup site. Subsequently the intracranial pressure in the coup site was decreasing toward negative value while the contra-coup intracranial pressure increasing toward positive values. Conclusions: The results illustrated that the stiffer and larger the stick was, the higher the von Mises stress, contact force and intracranial pressure were. We believed that the results in the Hybrid-III tests and THUMS head simulations for brain injury beaten with sticks could be reliable and useful for better understanding the injury mechanism.     

高频声像图对诊断乳腺肿块的意义

高频声像图对诊断乳腺肿块的意义林永，林新霖，石铮，陈玲，刘景丰，高美静关键词：高频声像图，乳腺肿块乳腺癌是女性常见的恶性肿瘤，Ｈｅｎｓｏｎ［１］报告１０年无瘤生存率低于３０％，其主要原因是病人延误诊断。为了提高生存率，目前临床上应用各种影像学检查方法...     

Good regulation of acupuncture in simple obesity patients with stomach-intestine excessive heat type

In order to investigate the regulatory effect of acupuncture on obesity patients with the Stomach-Intestine Excessive Heat Type, the pre-acupunctureal and post-acupunctural obesity index and biochemical indices of 718 simple obesity patients with Stomach-Intestine Excessive Heat Type were observed. It was showed that the marked weight loss effect was achieved in the cases by acupuncture, and the biochemical indices improved. It suggests that acupuncture had a optimal regulatory effect on the function of nerve, endocrine, digestion and energy metabolism.     

胞壁酰二肽激活小鼠原代肝窦内皮细胞中NOD2信号

目的调查小鼠原代肝窦内皮细胞(liver sinusoidal endothelial cells,LSECs)中NOD2信号通路激活后产生的免疫应答效应。方法使用胶原酶灌注方法结合percoll密度梯度离心加抗小鼠LSEC免疫磁珠分离纯化小鼠LSEC。定量PCR检测小鼠原代LSEC NOD1和NOD2 mRNA表达水平,同时给胞壁酰二肽刺激小鼠原代LSEC;定量PCR检测NOD2、RIP2、TNF-α和IL-6mRNA表达水平;定量ELISA检测细胞上清IL-6和TNF-α蛋白产量。结果小鼠原代LSEC中NOD2基础表达水平相对于NOD1基础表达水平较低。胞壁酰二肽刺激LSEC后诱导NOD2及其下游分子RIP2表达水平上调,接着诱导产生IL-6效应分子,而没有诱导产生TNF-α等其它细胞因子和趋化因子。结论胞壁酰二肽能够激活小鼠LSEC中NOD2介导的信号通路,并诱导产生IL-6效应分子,可能在维持肝脏内环境稳定中发挥着重要作用。     

心房粘液瘤对心房除极的影响

为探讨心房粘液瘤对心房激动过程的影响,对19例左心房粘液瘤和2例右心房粘液瘤的VCG高倍P环(1mV=360mm)进行测量,结果显示不同部位粘液瘤对心房激动的影响不同,VCGP环亦不同.左心房粘液瘤P环时限延长,除左心房肥大外,较容易判断出双侧心有肥大、房内传导阻滞.右心房粘液瘤P环时限正常,仅表现右心房肥大.VCG上放大的P环能比ECG上P波更敏感地反映出心房异常活动的电变化.     

Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus

Continuous renal replacement therapy(CRRT) is widely used for treating critically-ill patients in the emergency department in China. Anticoagulant therapy is needed to prevent clotting in the extracorporeal circulation during CRRT. Regional citrate anticoagulation(RCA) has been shown to potentially be safer and more effective, and is now recommended as the preferred anticoagulant method for CRRT. However, there is still a lack of unified standards for RCA management in the world, and there are m...     

BiPAP呼吸机治疗COPD急发并Ⅱ型呼吸衰竭的临床观察

目的 探讨BiPAP通气在救治慢性阻塞性肺疾病(COPD)急发并Ⅱ型呼衰的疗效.方法 将60例COPD急发并Ⅱ型呼衰分2组,在常规应用抗菌药物及对症治疗的基础上给予BiPAP通气5天,判断两者之间治疗前后生命体症及血气变化.结果 两组治疗5天后,BiPAP通气组在心率、呼吸频率及血气(PaO2及PaCO2)方面发送均显著优于对照组(P＜0.05).结论 BiPAP呼吸机治疗COPD急发并Ⅱ型呼吸衰患者,其在改善临床症状和动脉血气方面,均优于常规治疗,值得推广.     

CT引导^125Ⅰ放射粒子联合间质化疗治疗晚期非小细胞肺癌

目的 探讨CT引导^125Ⅰ放射粒子联合间质化疗治疗晚期非小细胞肺癌的临床价值,可行性和安全性。方法 回顾分析经病理证实的晚期非小细胞肺癌患者31例、33个病灶,在CT引导下植入^125Ⅰ放射性粒子,联合植入化疗粒子缓释剂中人氟安,比较治疗前及治疗后6个月肿瘤变化,判定疗效。结果 31例患者33个病灶,6个月后CT复查,CR 6例（19.4%）、PR 21例（67.7%）、NC 3例（9.7%）、PD 1例（3.2%）,有效率（CR＋PR）87.1%。术中4例出现少量气胸,1例肺内少量出血,术后1周内痰中带血丝3例。结论 CT引导^125Ⅰ放射粒子联合间质化疗治疗晚期非小细胞肺癌安全、微创、近期疗效明显。     

原发性下肢深静脉瓣膜功能不全戴戒术的疗效观察

目的 探讨戴戒术治疗下肢原发性深静脉瓣膜功能不全的疗效和手术经验。方法 ３５例（４７条肢体）下肢原发性深静脉瓣膜功能不全采用Ｇｏｒｅ－Ｔｅｘ人造血管行戴戒术治疗,在股浅静脉最高位第一对瓣膜下缩小原静脉周径１／４～１／３。结果 该手术简便、安全易掌握,疗效满意,为提高本手术效果,应做到：①熟悉掌握本术式的技术要点;②合理掌握手术适应和手术时机。