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目的探讨L5峡部裂并滑脱的手术治疗技巧及效果。方法回顾分析31例L5峡部裂并滑脱的患者,采用减压、复位、L5、S1椎间植骨,L4-5弹性固定的内固定术。结果所有病人经3月~2年的回访,术前Ⅰ度4例,Ⅱ度19例,Ⅲ度8例,术前单侧峡部裂的7例,双侧峡部裂的24例。术后优26例,良4例,可1例,无差级病例。结论减压、复位、固定和融合是治疗腰椎滑脱症的基本原则,术中彻底减压及术后植骨融合是保证疗效的关键。 相似文献
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在2003年1月~2005年11月,我院对46例颅脑损伤患者和17例高血压性脑出血患者实施了开颅手术治疗,手术后采用了腰池持续外引流血性脑脊液(CSF),取得良好效果,现报告如下. 相似文献
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目的探讨完全显微镜下颈椎后路椎管减压手术的临床疗效分析。方法选取2014年1月至2017年1月在本院因"颈椎管狭窄"住院的48例患者为研究对象。患者入院后,全部采用完全显微镜下颈椎后路椎管减压、椎板切除、植骨融合侧块钉棒系统内固定手术,经过治疗,对比全部患者术后和术前的神经功能改善情况,比较手术前、手术后JOA评分、Forankel分级、出血量分析、手术疗效计算资料采用t检验P0.05为差异有统计学意义。结果与手术前相比,48例患者中总改善率达98%,JOA评分显著提高,Forankel评分提高明显。结论完全显微镜下颈椎后路椎管减压手术治疗颈椎管狭窄症手术疗效显著。 相似文献
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外伤性脾破裂保脾手术方法的临床探讨 总被引:4,自引:0,他引:4
林云东 《中国现代医学杂志》2001,11(7):99-99,101
目的:探讨外伤性脾破裂的手术方法,方法:要用7号粗丝线U型交锁缝合修补脾破裂,结果:62例痊愈,2例再次手术切除脾脏,结论:脾破裂保脾手术方法多种,只要有保脾手术适应证。对某一手术方法掌握熟练,均可达满意疗效。文中讨论了保脾的意义,手术时机、方法、围术期治疗与疗效的关系。 相似文献
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目的 探讨环氧化酶-2(COX-2)抑制剂尼米舒利(NIM)对裸鼠胶质瘤移植瘤血管生成素(Ang)基因表达的影响及意义.方法 人胶质瘤SHG44细胞接种于裸鼠皮下,建立裸鼠胶质瘤移植瘤模型,并按随机数字表法分为对照组(灌注等量生理盐水)和NIM治疗组[6 mg/(kg·d)],逆转录PCR技术检测移植瘤组织Ang-1、Ang-2mRNA表达,免疫组织化学染色测定肿瘤组织微血管密度(MVD),并绘制肿瘤生长曲线和计算肿瘤抑制率.结果 NIM可有效抑制移植瘤的生长,其抑瘤率为42.03%.NIM治疗组肿瘤组织Ang-2 mRNA表达水平(0.2032±0.0185)较对照组(0.6024±0.0289)明显降低,差异有统计学意义(P<0.05);Ang-1 mRNA表达水平无明显改变,差异无统计学意义(P>0.05);Ang-2/Ang-1 mRNA比值下降(0.5825±0.0621vs 1.5847±0.1948),差异有统计学意义(P<0.05).NIM治疗组肿瘤组织MVD较对照组明显下降,差异有统计学意义(P<0.05).结论 COX-2抑制剂NIM可下调Ang-2基因表达,改变Ang-2/Ang-1 mRNA比值,抑制肿瘤生长.Abstract: Objective To investigate the effect of nimesulide (NIM), a selective cyclooxygenase-2 (COX-2) inhibitor, on angiopoietins (Ang) gene expression of human glioma xenografts in nude mice and its significance. Methods Human SHG44 glioma cells were inoculated subcutaneously in 16 nude mice to establish xenograft models, and then these mouse models were randomly divided into NIM treatment group and control group. NIM (6 mg/kg) and saline were poured into the stomachs of the mice in each group, respectively, once daily for 35 d. The mRNA expressions of Ang-1 gene and Ang-2 gene in the xenografts were determined by RT-PCR. Microvessel density (MVD) in the xenografts was assessed by immunohistochemical technique. The tumor growth curve was drawn and the inhibition ratio of tumor growth was calculated. Results NIM could significantly inhibit the glioma xenografts growth with its inhibition rate reaching 42.03%. The mRNA expression of Ang-2 gene in NIM treatment group (0.2032±0.0185) was significantly lower than that in control group (0.6024±0.0289, P<0.05), but that of Ang-1 gene showed no significant changes; therefore, the mRNA ratio of Ang-2/Ang-1 genes was decreased (0.5825±0.0621 vs. 1.5847±0.1948, P<0.05). MVD in the xenografts of the NIM treatment group was significantly lower than that in the control group (P<0.05). Conclusion NIM, by down-regulating the mRNA expression ofA ng-2 gene and changing the mRNA ratio of Ang-2/Ang-1 genes, can inhibit the tumor growth 相似文献
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