安全留置针与普通留置针在院前急救中的应用比较

目的对比观察安全型留置针与普通型留置针在院前急救静脉输液中的应用效果。方法将580例院前急救患者随机分为安全留置针组(290例)和普通留置针组(290例)。对2组的一次穿刺成功率、操作者与周围人群针刺伤发生率进行比较。结果安全留置针组一次穿刺成功率高于普通留置针组(p0.05)。普通留置针组针刺伤发生率高于安全留置针组(p0.05)。结论安全留置针在院前急救中心的应用效果优于普通留置针。     

综合康复护理对预防脊柱骨折术后患者下肢深静脉血栓的效果分析

目的观察综合康复护理对脊柱骨折术后患者下肢深静脉血栓的预防效果。方法 96例脊柱骨折患者随机分为康复组和对照组,每组各48例,术后均常规预防性皮下注射低分子肝素钙,康复组施行综合康复护理,对照组按常规护理,随访6~12个月,分别总结两组患者的效果。结果康复组患者中无下肢深静脉血栓发生,对照组有5例发生,两组发生率有明显差异（P〈0.05）,经过积极治疗和护理,5~7天后患肢肿胀消退,未出现肺栓塞等全身并发症。结论综合康复护理对脊柱骨折术后患者下肢深静脉血栓的预防效果明显,可在临床推广应用。     

CPCR后继发感染的分析及防治

<正> 心搏呼吸骤停的原因多种多样,CPCR的结果亦相差悬殊,因此CPCR后的处理十分复杂,涉及各个方面,除预防和纠正各种心律失常,维护心肾功能,纠正水、电解质紊乱及酸碱平衡失调外,预防感染是巩固CPCR成功的一个相当重要的环节,在临床护理与配合治疗方面尤为重要。1 CPCR后继发感染的原因1.1防御能力降低:CPCR后病人处于昏迷状态,机体防御能力降低,易招致感染。1.2 操作不洁性。①静脉切开;②气管切开;③开胸心脏挤压。④导尿操作等。1.3 肾上腺皮质激素等药物的应用:此类药物抑制机体免疫力,易导致感染。     

Anticancer Effect of Total Annonaceous Acetogenins on Hepatocarcinoma

Objective:To confirm the anticancer effect of total annonaceous acetogenins(TAAs)abstracted from Annona squamosa Linn,on human hepatocarcinoma.Methods:The inhibitory effect of TAAs was demonstrated in H_(22)-bearing mice.The potency of TAAs was confirmed as its 50%inhibiting concentration(IC_(50))on Bel-7402 cell under Sulfur Rhodamine B staining.Both underlying mechanisms were explored as cellular apoptosis and cell cycle under flow cytometry.Mitochondrial and recipient apoptotic pathways were differentiated as mitochondrial membrane potential under flow cytometry and caspases activities under fluorescence analysis.Results:The inhibitory rate of TAAs in mice was 50.98%at 4 mg/kg dose.The IC_(50)of TAAs on Bel-7402 was20.06μg/mL(15.13-26.61μg/mL).Effective mechanisms of TAAs were confirmed as both of arresting cell cycle at G_1 phase and inducing apoptosis dose-and time-dependently.Mitochondrial and recipient pathways involved in apoptotic actions of TAAs.Conclusion:TAAs is effective for hepatocarcinoma,via inhibiting proliferation and inducing apoptosis.