SMALL HEPATOCELLULAR CARCINOMA CUNlICA! A.NALYSIS OF 30 CASES

30 small hepatocellular carcinoma (HCC) cascs a.re reported. Of these 23 were detecfed by alpha-fetoprotein (AFP) in mass sccrvey and 7 clinically, Resection was successful in 22 cases. There was no operative mortality 8 cases underwent cryosurgery with ligation of the hepatic artery or radiation. The l,2 and 3 year survival rate of the cntire series was 80.4%, 55.4% and 46.9%; in the resected group it was 83.37%, 70.5% and 70.5% and in the non- resected group 63.8, 26.6e7v and 7.l%., The dif- fcrence between the 2 groups is Phighly signi- ficant Prognosis is markedly iraproved with early treatment, especially early resection. It is concluded ihat AFP screening is the method of ehoice for mass detection of small HCC. In this series, reliability of AFP diagnosis was 98.O%. Generally, diagnosis was made 7.9 months beforc symptoms occurred. However, long-term results are limited due to associated cirrhosis, multicentric development and the location of the neoplasm. Therefore research on the etiologic approach is impor- tant:     

乙型肝炎病毒脱氧核糖核酸在人原发性肝癌及癌旁组织中存在状态和与肝癌的关系

应用纯化的不含载体质粒顺序的~(32)P-HBV DNA探针(3.2Kb),分析了66例人原发性肝癌中的DNA存在状态,发现34例(51.5％)有不均一的HBV DNA整合;14例(21.2％)存在复制型的游离HBV DNA;11例(16.7％)同时存在整合及游离HBV DNA,7例(10.6％)未见到HBVDNA痕迹。同时对20例癌及癌旁肝组织同时存在有整合型HBV DNA的病例,比较了癌与癌旁肝组织的HBV整合谱型,发现15例(75％)显示不同的整合区带;5例(25％)具有相似的整合谱型。