2型糖尿病增加结直肠腺瘤和癌的风险

美国明尼苏达州罗切斯特市梅奥临床医学院Paul J．Limburg及其同事们在Am J Gastroenterol杂志上报告的一项基于人口的研究显示,2型糖尿病与结直肠癌流行率增加相关,特别在男性。他们指出,以前很多研究检查了糖尿病和结直肠腺癌之间的关系,但结果都很矛盾。因     

Pediatric intracranial aneurysms——clinical characteristics and therapeutic strategies

Objective To assess the radiological characteristics and therapeutic strategies of intracranial aneurysms in children. Methods From our dedicated neurovascular databank of patients, we reviewed 23 consecutive children who had 24 intracranial aneurysms. There were 14 boys and 9 girls with a mean age of 9.09 years ( range 1 - 14 years ). Results Intracranial aneurysms in children ≤ 14 years constituted 1.3% of all intracranial aneurysms. Internal Carotid artery (ICA) and middle cerebral artery (MCA) were the most frequent sites for aneurysms. About 58.3% of the aneurysms were complex, including dissecting, pseudoaneurysm, giant and fusiform aneurysm. 1/3 of all aneurysms were located in posterior circulation. Only 1 case had multiple aneurysms in this case series. Almost half of all cases presented with subarachnoid hemorrhage and others presented with mass effect. 14 cases underwent endovascular treatment. 4 patients received microsurgical therapy. 5 cases did not receive microsurgical or endovascular therapy, 2 of them whose aneurysms spontaneously thrombosed during follow up. One boy with left vertebral artery giant aneurysm died after endovascular therapy owing to gradual thrombosis in basilar artery. Another child had poor outcome because of rerupture of aneurysm before operation. Whereas the majority had a favorable outcome. Conclusions Intracranial aneurysms in children had many clinical and radiological characteristics different from those in adults : ( 1 ) remarkable male predominance; ( 2 ) ICA and MCA were the most common sites for aneurysms; (3) high incidence of large, traumatic, infectious, dissecting and fusiform aneurysms. (4)For pediatric intracranial aneurysms, both microsurgical approaches and endovascular treatment were effective. Endovaacular therapy was the best choice for complex aneurysms.     

脸色腰段椎间盘突出症21例临床分析

胸腰段椎间盘突出症罕见,约占椎间盘突出的0.6％～4％。随着CT及MRI的应用,其发病率有增加的趋势。因其发病率低,报道较少。但由于病变位于脊髓圆椎段,其发病较下腰段椎间盘突出有很大的特殊性,故有必要结合我院近年收治的21例对其作一回顾性分析。1 临床资料     

用氮源调控的FLD1启动子开发在毕赤酵母中生产外源蛋白的高细胞密度流加补料培养技术

构建了一株可在P．pastoris甲醛脱氢酶1基因的启动子（PFLD）转录控制下，表达稻根霉脂肪酶基因的毕赤酵母重组菌，以研究该表达系统可否用于无需甲醇诱导的高细胞密度流加补料培养技术生产重组蛋白。使用PFLD系统开发了简单可靠的流加补料技术，在诱导期分别用甲胺和山梨醇作为氮源和碳源。在3种恒定生长速率下分别进行3项流加补料发酵试验，     

服药喝水也有大学问

<正>你知道怎样吃药吗,不要以为医生开了药或从药师手中接过药,照说明书上用法用法就万事大吉。正确的服药方法可以提高药物的吸收,增强药物的疗效,还可以降低药物的副作用,避免与其他药物和食     

巡回性诊疗护理与老年人保健

饭富病院地处日本本州山黎县,远离大都市,地偏人稀,但环境优美,气候宜人,的确是疗养的好地方。饭富病院属公立医院,虽规模较小,但是一所综合性医院。我们在此院研修3个月,时间虽短,但期间的所见所闻,尤其护理方面给我们的启发和教益却是十分深刻的。现介绍几个片断,以飨读者。1     

乳头乳晕组织扩张后乳头再造

本文介绍一种新的扩充软组织乳头再造方法。即在残存乳头，乳晕皮肤软组织下应用扩张器，然后形成乳腺组织瓣作支撑，行乳头再造，作者详细介绍了切口设计的操作方法。     

“饲养细胞”在建立恶性疟原虫红内期体外培养中的作用

在建立恶性疟原虫（Ｐ．ｆ）新分离株体外连续培养的初期，使用小鼠腹腔洗脱细胞（主要是单核巨噬细胞）作为“饲养细胞”。结果表明，在饲养细胞的辅助下，Ｐ．ｆ虫株很快适应体外培养条件，生长发育良好，６周后停用饲养细胞，虫株仍能继续正常生长繁殖。     

异位心(胸腹型)1例报告

异位心是罕见的先天性畸形,以胸部型心异位最为常见。我们遇到1例胸腹型异位心,为明确心内畸形作了全面检查,现报告如下.患者,女,19岁,自幼发现心脏杂音,平时易受凉发烧,活动后气喘,一岁后逐渐出现紫绀,无蹲踞及晕厥史.发育营养较差,口唇、面部紫绀,杵状指趾。BP110/70mmHg,P88次/分。胸部对称,