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1.
聚合酶链反应诊断女性外阴尖锐湿疣初步探讨郑惠方单祥年李明发蒋清龚嘉仪(南京铁道医学院附属医院妇产科,生物学教研室,附属医院病理科南京210009)尖锐湿疣(CA)主要由人乳头瘤病毒(HPV)6及11型DNA感染引起。尖锐湿疣和假性湿疣... 相似文献
2.
病人 ,女 ,43岁 ,因上腹部不适 ,隐痛来院就诊。采用日本东芝 PRO- 35 0彩超诊断仪 ,探头频率 3.5 MHz。超声检查 :肝脏外形正常 ,被膜光滑 ,回声均匀 ;胆囊及肝内外胆管无扩张 ;胰头及部分可见胰体回声正常 ;胰腺体尾部见一液性暗区 90mm× 88mm,囊壁光滑 ,与周围胰腺脾、肾组织界限清楚。囊腔内可见粗细不等的略强回声分隔光带 ,调整增益 ,部分房内可见密集点状回声或混合性结节 ,呈乳头状。胰管不扩张。腹主动脉旁可见低密度结节 5 mm× 6mm,1 0 mm× 1 4mm。B超诊断 :胰腺囊腺癌 ,术后病理回报与 B超相符。讨论 :胰腺囊腺癌来自胰腺… 相似文献
3.
1 Introduction It is well known that mechanical forces have important influence on endothelial cells, in particular, on cytoskeleton reorganization. VASP (vasodilator stimulated phosphoprotein) is a 46 KD actin associated protein. It is a member of Ena/VASP protein family and composed of EVH1, proline-rich and EVH2 domains. It is considered as an important component of the sub-cellular regions where remodelling of the actin cytoskeleton takes place, such as the front of spreading lamell… 相似文献
4.
Riadh Nciri Ezzeddine Bourogaa Samira Jbahi Mohamed Salah Allagui Abdelfattah Elfeki Christian Vincent Franoise Croute 《中国神经再生研究》2014,9(7):735-740
To investigate the molecular mechanism underlying the neuroprotective effect of lithium on cells, in this study, we exposed SH-SY5Y cells to 0.5 mmol/L lithium carbonate(Li2CO2) for 25–50 weeks and then detected the expression levels of some neurobiology related genes and post-translational modifications of stress proteins in SH-SY5Y cells. cDNA arrays showed that pyruvate kinase 2(PKM2) and calmodulin 3(CaM 3) expression levels were significantly down-regulated, phosphatase protein PP2A expression was lightly down-regulated, and casein kinase II(CK2), threonine/tyrosine phosphatase 7(PYST2), and dopamine beta-hydroxylase(DBH) expression levels were significantly up-regulated. Besides, western blot analysis of stress proteins(HSP27, HSP70, GRP78 and GRP94) showed an over-expression of two proteins: a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27. These results suggest that the neuroprotective effects of lithium are likely related to gene expressions and post-translational modifications of proteins cited above. 相似文献
5.
目的:观察百令胶囊对频繁发作慢性阻塞性肺疾病(COPD)病人免疫功能和肺功能的影响。方法: 选取 100 例年发作次数在 2 次以上,每次发作均来本院呼吸内科住院诊治的慢性阻塞性肺疾病急性加重期病人 (AECOPD)。52 例对照组病人在常规治疗的基础上增加无创正压通气(NIPPV),48 例观察组病人在对照组之 上增加百令胶囊治疗。观察两组病人治疗前后免疫功能和肺功能情况。结果:观察组临床治疗有效率为83.33% 显著高于对照组的65.38%,有统计学意义(χ2 = 4.18,P<0.05);观察组治疗后 FEV1 、FEV1 预测值、FEV1 / FVC 均 高于对照组,差异有统计学意义(P<0.05);观察组治疗后 T 淋巴细胞亚群 CD4+、CD4+ / CD8+高于对照组,CD8 +低于对照组,均有统计学差异(P<0.05)。结论:采用百令胶囊辅助治疗,可改善病人免疫功能,提高肺功能,有 望降低 AECOPD 发作次数。 相似文献
6.
《甲乙经》一书,乃《针灸甲乙经》之简称,为晋代皇甫谧据《素问》、《针经》、《针灸治要》三书内容除去重复重新归类编撰而成,是针灸学的一部宝贵典籍。由于年代久远,文字错简脱落者有之,亥豕鲁鱼者有之,字形义训变迁者亦有之,今人一般很难通读之,必须采用研究古籍方法始克奏效。 相似文献
7.
患者张某,男,44岁,1980年5月22日门诊。
据患者述1960年感右胁隐痛,疑为肝炎,而作超声波、肝功能检查,结果均无异常发现。右胁隐痛持续至1965年5月,每日痛2~3次,有时可间歇半个月不痛,痛位不甚固定,并连及右腰背,当时又疑为胆囊炎,在某院住院检查,行胆囊造影及。肾脏造影均无异常。 相似文献
8.
Raquel Francine Liermann Garcia Simone Moreira Ana Lucia de Araújo Ramos Leslie Ecker Ferreira Angelo Alves de Mattos Cristiane Valle Tovo Lysandro Alsina Nader Juliene Antonio Ramos Edson Rondinelli Arnaldo de Jesus Dominici Christian Evangelista Garcia Mauro de Souza Leite Pinho Carlos Eduardo Brando-Mello Cristiane Alves Villela-Nogueira Paulo Henrique Condeixa de Frana 《World journal of gastroenterology : WJG》2013,19(42):7399-7404
AIM:To analyze the role of rs12979860 and rs8099917polymorphisms in hepatitis C virus(HCV)genotype 1infection of Brazilians.METHODS:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C(CHC)who had completed a 48-wk regimen of pegylated-interferonα-2a or-2b plus ribavirin combination therapy were recruited from six large urban healthcare centers and199 healthy blood donors(controls)from a single site between January 2010 and January 2012.Data on the patients’response to treatment was collected.Polymerase chain reaction-restriction fragment length polymorphism genotyping of the interleukin(IL)28B gene fragment encompassing the single nucleotide polymorphisms(SNPs)rs12979860(C/T)and rs8099917(T/G)was carried out for 79 of the CHC patients and 199 of the controls.Bi-directional amplicon sequencing of the two SNPs was carried out for the remaining 66 CHC patients.RESULTS:SNP rs12979860 genotyping was successful in 99.5%of the controls and 97.2%of the CHC patients,whereas the SNP rs8099917 genotyping was successful in 95.5%of the controls and 100%of the CHC patients.The genotype and allele distributions for both rs12979860 and rs8099917 were significantly different between the control and CHC patient groups,with significantly higher genotype frequencies of CC and TT in the controls(P=0.037 and 0.046,respectively)and of TT and GG in the CHC patients(P=0.0009and 0.0001,respectively).Analysis of the CHC patients who achieved sustained virological response(SVR)to treatment(n=55)indicated that the rs12979860 C allele and CC genotype were predictors of SVR(P=0.02).No significant correlation was found between rs8099917 genotypes and treatment response,but carriers of the T allele showed significantly higher rates of SVR(P=0.02).Linkage disequilibrium analysis of the group that achieved SVR showed a significant association between rs12979860 and rs8099917(P=0.07).CONCLUSION:The higher allele frequency of rs12979860 C and rs8099917 T observed in non-HCVinfected individuals may indicate a potential pro 相似文献
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10.