老年性痴呆病因病机探析

老年性痴呆是伴随着人类衰老而出现的常见病、多发病.其中阿尔茨海默病(Alzheimerdisease, AD)和血管性痴呆(vascular dementia, VD)是两大主要类型.随着世界人口的老龄化,痴呆在老年人的疾病谱和死亡谱中已占有十分重要且突出的地位,并成为老年人群中仅次于心脏病、恶性肿瘤和脑卒中之后的第4位死亡原因,严重威胁中老年人身体健康和生活质量.     

祛浊化痰中药干预食饵性动脉粥样硬化模型兔血脂及相关炎性因子的变化

BACKGROUND: Many animal experiments and clinical observation proved that dispelling turbid phlegm herb has good adjustment function on serum lipid, lipoprotein and liver lipid. OBJECTIVE: To observe the effects of dispelling turbid phlegm herb on monocyte chemotactic factor-1, C-reactive protein and serum lipids in rabbits with dietary atherosclerosis.  METHODS: A total of 50 New Zealand white rabbits were randomly divided into five groups. Rabbits in the blank control group were fed with basic feed, and simultaneously intragastrically administrated physiological saline 10 mL/kg per day, for 10 consecutive weeks. Rabbits in the model group were given high-fat diet to prepare atherosclerosis models, and simultaneously intragastrically administrated physiological saline 10 mL/kg per day, for 10 consecutive weeks. Rabbits in the phlegm turbidity treatment group were given high-fat diet to prepare atherosclerosis models, and simultaneously intragastrically administrated dispelling turbid phlegm herb 10 mL/kg per day, for 10 consecutive weeks. Rabbits in the Xuezhikang group were given high-fat diet to prepare atherosclerosis models, and simultaneously administrated Xuezhikang 10 mL/kg per day, for 10 consecutive days. Rabbits in the phlegm turbidity treatment group were given high-fat diet for 10 weeks to prepare atherosclerosis models, and intragastrically administered physiological saline 10 mL/kg per day for 6 weeks, and then given dispelling turbid phlegm herb 10 mL/kg per day for 4 weeks. At 10 weeks, serum lipid, C-reactive protein, and monocyte chemokine 1 mRNA expressions were detected, and pathological observation of the aorta was performed. RESULTS AND CONCLUSION: Xuezhikang and dispelling turbid phlegm herb could decrease serum total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipid protein cholesterol, C-reactive protein and monocyte chemokine 1 mRNA expression level, and apparently inhibited atherosclerotic changes. The preventive effect of dispelling turbid phlegm herb was better that its therapeutic effect.      

益气强心煎剂对慢性心力衰竭大鼠血清AngⅡ浓度及心室重构相关因子表达的影响

目的:探讨益气强心煎剂对慢性心力衰竭大鼠血清AngⅡ浓度以及心肌组织periostin、collageⅠ蛋白表达的影响。方法:成年雄性SD大鼠120只,随机选取20只作为对照组,余下100只建立心衰模型。造模成功后,随机分成5组,模型组(每日1次灌服同等体积的生理盐水)、益气强心煎剂高剂量组(以6.36 g/100 g体质量灌胃)、益气强心煎剂中剂量组(以3.18 g/100 g体质量灌胃)、益气强心煎剂低剂量组(以1.59 g/100 g体质量灌胃)、西药对照组(以洛丁新0.45 mg/kg体质量灌胃),上述药物与生理盐水制成3 mL溶液或混悬液,每日灌胃1次。用药4周后,观察所有大鼠心脏形态学、血清AngⅡ浓度以及心肌组织periostin、collageⅠ蛋白表达水平。结果:心脏形态学方面,对照组心肌细胞排列整齐紧密,分布均匀,形态正常。模型组心肌细胞大面积变性坏死,分布不均,间质纤维组织增生,少量炎性细胞浸润,心肌细胞交织成网状,心肌纤维出现断裂缺失、坏死和纤维化改变。AngⅡ浓度方面,与模型组比较,益气强心汤高剂量组、洛丁新组大鼠血清AngⅡ浓度偏低(P0.05),与益气强心汤高剂量组相比,洛丁新组AngⅡ浓度较低(P0.01)。与模型组比较,各组大鼠心肌组织periostin蛋白表达水平较低,其中洛丁新组益气强心汤高剂量组益气强心汤低、中剂量组(P0.01);与模型组比较,益气强心汤中、高剂量组,洛丁新组大鼠心肌组织collageⅠ蛋白表达水平较低,其中洛丁新组益气强心汤高剂量组益气强心汤低剂量组(P0.01)。结论:益气强心汤能够有效调节慢性心力衰竭大鼠心肌纤维化发展,延缓左室重构,改善心功能,其机制可能与其调节慢性心衰大鼠血清AngⅡ浓度,抑制collagenⅠ与periostin蛋白表达相关。     

老年性痴呆病因病机探析

老年性痴呆是伴随着人类衰老而出现的常见病、多发病。其中阿尔茨海默病（Alzheimer disease,AD）和血管性痴呆（vascular dementia．VD）是两大主要类型。随着世界人口的老龄化,痴呆在老年人的疾病谱和死亡谱中已占有十分重要且突出的地位,并成为老年人群中仅次于心脏病、恶性肿瘤和脑卒中之后的第4位死亡原因,严重威胁中老年人身体健康和生活质量。流行病学调查,老年性痴呆的发病率占老年人的7％～8％,且患病率呈逐年上升趋势。近年来我国上海市和美国多家科研机构联合进行痴呆患病率的调查结果表明,AD是引发痴呆的首位原因,约占2／3。因此,对于老年性痴呆的认识和治疗有着重要的医学和社会意义。