降糖灵中毒抢救的护理体会

降糖灵中毒抢救的护理体会我科于１９９１年６月２８日收治１例误服大量双胍类药物降糖灵中毒患者，经抢救、治疗和精心护理痊愈出院。现将有关护理体会报告如下。冯某，男，５５岁，农民。因患糖尿病１年，呕吐２天，昏迷１０ｈ于１９９１年６月２８日入院。患者６月２４...     

穴位埋线治疗单纯性肥胖35例观察

单纯性肥胖是指由于能量摄入超过消耗,导致体内脂肪积聚过多,且无明显内分泌病因造成的疾病,可占肥胖总数的95%以上。它不仅影响美观,严重时可引发糖尿病、高血压、高血脂等多种疾病。穴位埋线是最近这些年兴起的一种治疗肥胖症的绿色方法。其安全性高,副作用少,不仅省时,经济有效,     

少商放血治疗慢性咽喉炎临床观察

慢性咽喉炎是咽喉部的慢性炎症,是临床常见病、多发病,为上呼吸道慢性炎症的一部分,病程较长.多为急性咽喉炎反复发作迁延而致[1].临床上主要表现为咽喉异物感、灼热、干燥感或微痛、咽痒、刺激性咳嗽等咽部不适症状.检查可见咽部黏膜慢性充血,咽后壁淋巴滤泡增生,或咽部黏膜干燥萎缩.作者自2009年5月至2010年8月采用少商放血疗法治疗慢性咽喉炎56例,取得了满意的疗效,现总结如下.     

SHOX2基因甲基化水平对肺癌和良性肺部疾病的鉴别诊断研究

Objective　To evaluate the value of SHOX2 gene methylation level for differential diagnosis in patients with lung cancer and benign lung diseases.Methods　Patients with lung cancer and benign lung diseases hospitalized in the Department of Thoracic Surgery and Department of Eespiration of the Central Hospital of Wuhan from March 2014 to June 2016 were enrolled.Among them,173 patients with lung cancer were defined as lung cancer group,and 194 patients with benign lung diseases as benign lung disease group.Routine serological examination and tumor markers were detected in all patients.The SHOX2 gene methylation was detected by Sanger sequencing,and the SHOX2 gene methylation level was calculated by △△CT method.The value of each index in differential diagnosis of lung cancer was analyzed by receiver operating characteristic（ROC） curve.The relationship between each index and lung cancer pathological type and TNM staging was analyzed.Results　The white blood cell count（WBC） and △△CT value of lung cancer group were lower than those of benign lung disease group,while the serum gastrin releasing peptide precursor（ProGRP）,squamous cell carcinoma antigen（SCC-Ag）,cytokeratin 21 fragment antigen（Cyfra21-1） and carcinoembryonic antigen（CEA） were higher than those in benign lung disease group（P<0.05）. The result of multivariate Logistic regression analysis showed that serum ProGRP,serum Cyfra21-1,and △△CT values were factors influencing lung cancer（P<0.05）. The area under ROC curve（AUC） of △△CT value for the diagnosis of lung cancer was 0.843.The sensitivity was 58.2%,and the specificity was 93.1% when the optimal threshold was 2.69.The AUC of serum ProGRP was 0.711,with optimal threshold of 32 ng/L,sensitivity of 63.5% and specificity of 77.4%.The AUC of serum Cyfra21-1 was 0.677,the best cut-off value 2.92 μg/L,sensitivity 56.1%,and specificity 72.3%.The AUC of serum ProGRP for the diagnosis of lung cancer was greater than that of serum Cyfra21-1（Z=3.569,P=0.038）. The AUC of the △△CT value combined with serum ProGRP was 0.860.The AUC of △△CT value combined with serum ProGRP in the diagnosis of lung cancer were greater than that of △△CT value,serum ProGRP,and serum Cyfra21-1（Z=4.046,Z=5.607,Z=8.215,P<0.05）. The △△CT value of patients with squamous cell carcinoma,small cell carcinoma was lower than that of patients with adenocarcinoma,large cell carcinoma and other unknown pathological types（P<0.05）. The △△CT value of patients in stage Ⅲ lung cancer was lower than that of those in stage Ⅰ and stage Ⅱ（P<0.05）,and the △△CT value of patients in stage Ⅳ lung cancer was lower than that of those in stage Ⅰ,stage Ⅱ and stage Ⅲ（P<0.05）. Conclusion　SHOX2 gene methylation has its value in the differentiation of lung cancer and benign lung disease.It is correlated with lung cancer pathological type and TNM staging,which can be used as an auxiliary index for diagnosis of lung cancer.     

上海市闵行区小学教师对学生运动伤害的KAP调查

当前伤害已经成为危害儿童青少年健康的重要原因之一,也是发达国家和发展中国家青少年的首位死因。以往的研究结果表明,学校是伤害的主要发生场所之一,教师作为小学生在学校中的直接教育者和保护者,在伤害预防控制的环节中起着重要作用,他们对伤害知识的了解程度与其对学生的安全教育开展情况直接相关,通过对其进行干预能有效预防学生在学校发生运动伤害。我们通过分析干预前后教师对学生中常见运动伤害相关知识知晓情况的变化,为干预效果评估提供依据。     

黄芫花乙醇液的稳定性实验

目的：考察黄芫花乙醇液的稳定性,方法：用ＨＰＬＣ法测定含量,以经典恒温加热预测有效期。结果：各国温条件下加热时间与含量对数变化线性关系良好,结论：黄芫花乙醇液在２０℃的有效期提定为４年,在２５℃的有效期为２年。     

非小细胞肺癌患者介入治疗前后血清HIF-1α、VEGF的变化及相关性研究

目的:探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)患者介入治疗前后血清缺氧诱导因子-1α(hypoxia-inducible factor 1 alpha,HIF-1α)和血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的动态变化规律及两者间的相关性。方法:采用酶联免疫吸附试验法(enzymelinked immunosor-bent assay,ELISA)检测40例NSCLC患者介入治疗前、后及30例健康体检者血清HIF-1α、VEGF水平。结果:NSCLC患者血清HIF-1α水平(49.03±8.36)ng/L显著高于正常对照组(37.69±3.33)ng/L(P<0.001);介入治疗前、治疗后1天及7天血清HIF-1α水平分别为:(49.03±8.36)ng/L、(53.46±7.66)ng/L、(60.83±9.43)ng/L,组间比较差异具有统计学意义(P<0.02);NSCLC患者血清VEGF水平(742.71±113.09)pg/ml显著高于正常对照组(592.81±71.01)pg/ml(P<0.001);介入治疗前、治疗后1天及7天血清VEGF水平分别为(742.71±113.09)pg/ml、(877.47±164.29)pg/ml、(1119.00±164.27)pg/ml,组间比较差异具有统计学意义(P<0.001)。介入治疗前、介入治疗后1天及7天血清HIF-1α水平与血清VEGF水平均存在正相关性(r=0.506,P<0.01;r=0.406,P<0.01;r=0.525,P<0.01)。结论:NSCLC患者血清HIF-1α及VEGF水平介入治疗后显著升高,且两者存在显著正相关性。