西安市新生儿、婴儿体格发育探讨

在西安市１９９５年进行的０～７岁儿童体格发育调查中,对新生儿、婴儿体格发育特征进行探讨。具体如下：①五项指标：出生时除城男坐高（３５．０ｃｍ）略高于郊男（３３．７ｃｍ）外（Ｐ＜０．０５）,其它城郊男女均无显著差异（Ｐ＞０．０５）。生后０～１２月城男优于郊男（Ｐ＜０．０５）,城女优于郊女（Ｐ＜０．０５）,男童优于女童（Ｐ＜０．０５）。②五项指标增长速度：城市婴儿高于效区（Ｐ＜０．０５）,男婴除个别组外均显著高于女婴。③胸头围比：城女在２月时为１．０２,城男在４月时为１．００５,郊男、郊女交叉时间与…     

ERAP1基因多态性与非小细胞肺癌遗传易感性的关联研究

目的：探讨内质网氨肽酶1（endoplasmic reticulum aminopeptidase 1,ERAP1）基因多态性与非小细胞肺癌（non-small cell lung cancer,NSCLC）的相关性。方法入选NSCLC患者224例,健康体检人群207例。采用Taq Man探针基因分型方法对ERAP1基因SNP rs26653和rs26618两个位点进行基因分型,并构建单倍型,评估上述两个SNPs及单倍型与NSCLC的相关性。结果病例组和对照组ERAP1基因rs26618和rs26653基因型和等位基因频率差异有统计学意义（P＜0.05）。病例组和对照组rs26618/rs26653单倍型CG、TC的单倍型频率差异有统计学意义（P＜0.05）。结论 ERAP1基因与NSCLC的发生有关, rs26618/rs26653-CG单倍型可能增加NSCLC的患病风险,rs26618/rs26653-TC单倍型对NSCLC可能具有保护性作用。     

美容养颜说“贫血”

从古至今对一位女性美好容颜的赞誉莫若“人面桃花”了,施粉抹脂为的也是追求这样的效果,各种热敷术、按摩术、玉容养颜补剂等等又都在此做“文章”。做为一名妇幼保健工作者,我要说的是“贫血”——容颜如玉的大敌。血液循环是生命的河流,在这里流淌着由血浆与血细胞组成的红色粘稠的“河水”。血浆的主要功能是运载血细胞,运输养料和废物,使人体组织细胞生活的液体环境保持相对稳定,以利于细胞进行正常的生理活动。血细胞包括红细胞、白细胞和血小板。红细胞里有     

隔药灸对肿瘤坏死因子-α介导克罗恩病肠上皮细胞凋亡途径的影响

目的:观察隔药灸对肿瘤坏死因子-α(TNF-α)-肿瘤坏死因子受体相关死亡结构域(TRADD)-Fas相关的死亡结构域(FADD)途径介导克罗恩病(Crohn's disease,CD)肠上皮细胞凋亡的影响,探讨其作用机制。方法:将48只SD雄性大鼠随机分成正常组、模型组、隔药灸组和西药组,每组12只。采用2,4,6-三硝基苯磺酸(TNBS)制备CD模型,造模成功后隔药灸组采用隔药饼灸"天枢""气海"穴,每日1次,每次每穴隔药灸2壮,共灸10d。西药组采用美沙拉嗪灌胃,每日2次,每次2mL,共灌胃10d。治疗结束后取各组大鼠结肠上皮组织,分离、纯化和培养结肠上皮细胞建立体外肠上皮细胞屏障模型,将100ng/mL TNF-α分别与各组肠上皮细胞孵育培养24h,应用荧光黄透过率检测各组肠上皮细胞屏障通透性,Western blot法检测各组肠上皮细胞凋亡途径相关蛋白肿瘤坏死因子受体1(TNFR1)、TRADD、受体作用蛋白1(RIP1)、FADD、锌指蛋白A20(A20)表达以及流式细胞术观察各组肠上皮细胞凋亡情况。结果:与正常组比较,模型组的荧光黄透过率显著升高(P0.001),结肠上皮细胞TNFR1、TRADD、RIP1表达量明显升高(P0.01),A20表达量明显降低(P0.01),细胞凋亡率显著增高(P0.001)。与模型组比较,隔药灸组和西药组的荧光黄透过率显著降低(P0.001),结肠上皮细胞TRADD、RIP1、FADD表达量明显降低(P0.01),A20表达量明显升高(P0.01),结肠上皮细胞凋亡率显著降低(P0.001)。结论:隔药灸可能是通过调控TNF-α介导CD肠上皮细胞凋亡途径的异常,达到保护或修复CD肠上皮屏障损伤之效应。     

种植义齿支架适合性的临床评估方法

种植义齿修复中,种植支架与下部结构的被动适合(passive fit)对于达到成功的骨整合是非常关键的。许多学者尝试明确提出种植修复体的适合性的可接受水平:Branemark在1983年率先将被动适合定义为10μm的水平,该水平能使骨在(牙合)力作用下成熟和改建。Klineberg和Murray在1985年则认为间隙大于3μm超     

应力对体外培养破骨细胞影响的研究

骨代谢受各种机械力的影响,对骨吸收起重要作用的破骨细胞也受各种应力的影响。本文就破骨细胞的体外培养及鉴定标准,应力对体外培养破骨细胞的影响及其机制作一综述。     

科学饮食可减缓生理功能衰退

人的生理衰退期从40岁左右开始,随年龄增长生理功能发生系列变化,导致人体衰老。 老龄性身体最大变化是组成身体细胞数减少,70岁细胞总数仅为20～30岁人的2/3,各器官重量相应减轻,高龄者肝脏、脾脏、肾脏重量分别为年轻人的67％、45％、81％,但脑重量几乎不变。其次是人体细胞内水分显著减少。75岁高龄人与25岁     

颞下颌关节骨关节炎患者滑膜受累的光镜研究

本文旨在通过光镜研究骨关节炎的颞下颌关节中滑膜的特征,以评估滑膜在骨关节炎进展过程中的作用。 作者对40例长期接受非外科治疗的难治性颞下颌关节病患者(女33例,男7例,平均29.4岁)以关节镜取单侧关节上腔滑膜活检。经固定、包埋、切片后以甲苯胺蓝染色。其种31例被诊断为有骨关节炎,定为骨关节炎组,组内又再根据有无关节盘移位和穿孔引起的症状分为:无关节盘累及组(ADI组,6例)、可复位的关节盘移位组(RDD组,0例)、关节盘移位组(PDD组,22例)、关节盘穿孔组(DP组,3例)。另外9例患者无骨关节炎,定为对照组,组内又分为疼痛性移位过度(6例)、创伤性关节炎(2例)、疼痛性过载荷(1例)3组。 光镜观察结果发现骨关节病组滑膜内膜细胞层数显著多于对照组,纤维内膜基质及内膜下纤维化也显     

Analysis of acupoint-selection patterns in acupuncture-moxibustion treatment of polycystic ovarian syndrome based on data mining

Objective

To analyze the meridian and acupoint-selection patterns in acupuncture-moxibustion treatment of polycystic ovarian syndrome (PCOS) by data mining technique, for exploring acupoints that could be effective for PCOS and providing suggestion and reference in selecting acupoints for the acupuncture-moxibustion treatment of PCOS.

Methods

Literatures related to the acupuncture-moxibustion treatment of PCOS published before April 2018 were collected. By a self-made data mining program developed using Microsoft Excel 2007, a database of acupuncturemoxibustion treatment of PCOS was then established. The correlation analysis was performed for the frequency of use of acupoints and acupoint groups. Cluster analysis was also conducted.

Results

A total of 92 articles were recruited finally. Sanyinjiao (SP 6), Conception Vessel and chest-abdomen region ranked the top on the list of the most frequently used acupoints, meridians and regions, respectively. Correlation analysis showed that the acupoint group with the highest confidence was Sanyinjiao (SP 6) and Zusanli (ST 36), and the group with the highest support was Sanyinjiao (SP 6) and Guanyuan (CV 4). Cluster analysis revealed five effective clusters: Guanyuan (CV 4) and Sanyinjiao (SP 6); Zhongwan (CV 12) and Tianshu (ST 25); Zhongji (CV 3), Zusanli (ST 36) and Qihai (CV 6); Xuehai (SP 10), Shenshu (BL 23), Taichong (LR 3) and Guilai (ST 29); Ganshu (BL 18), Taixi (KI 3), Yinlingquan (SP 9) and Pishu (BL 20).

Conclusion

According to the confidence and support report, Sanyinjiao (SP 6) and Zusanli (ST 36) or Sanyinjiao (SP 6) and Guanyuan (CV 4) are recommended in acupuncture-moxibustion treatment of PCOS, with adjunct points selected for different patterns, e.g. Zhongwan (CV 12) and Tianshu (ST 25) for tonifying spleen and expelling dampness; Zhongji (CV 3) and Qihai (CV 6) for supplementing qi and cultivating blood; Xuehai (SP 10), Shenshu (BL 23), Taichong (LR 3) and Guilai (ST 29) for tonifying kidney and dissolving stasis; Ganshu (BL 18), Taixi (KI 3), Yinlingquan (SP 9) and Pishu (BL 20) for tonifying kidney and spleen and regulating liver.