成年人肝未分化肉瘤合并炎性假瘤1例报告

患者男性,52岁。因上腹部持续性闷痛伴发热,纳差,消瘦2~+月,拟诊溃疡病于1989年5月3日入院。既往无肝炎及胆道感染史。体检:巩膜无黄染,浅表淋巴结不大;腹肌软,剑突下偏右可扪及8×5×3cm肿物,质硬,表面不平,有压痛,活动度差;肝脾肋下未及,腹水征(-)。直肠指检未及异常。化验室检查:WBC6.79×10~9/L,肝功能正常,HBsAg(-),AFP(-),A/G4.12/2.70;B超示肝左叶有一4.5×4.5cm低回声区,考虑为肝癌;CT:肝门区有一直径约1cm高密度影,左外叶有块状5×     

参附青注射液对休克大鼠血压、心脏血液动力学和肠系膜微循环的影响

采用内毒素休克和心源性休克大鼠模型，观察参附青注射液对血压、心肌收缩力、肠系膜微循环的影响。结果表明，该方对内毒素休克大鼠上述指标有明显改善，而仅改变心源性休克大鼠的微循环     

参附青注射液对休克大鼠血压、心脏血液动力学和肠系膜微循环的影响

采用内毒素休克和心源性休克大鼠模型，观察参附青注射液对血压、心肌收缩力、肠系膜微循环的影响。结果表明，该方对内毒素休克大鼠上述指标有明显改善而仅改变心源性休克大鼠的微循环。     

非那雄胺与多沙唑嗪联用对鼠前列腺增生模型的影响

目的:探讨非那雄胺与多沙唑嗪联用对鼠前列腺增生模型的影响。方法:将34只雄性W istar大鼠,随机分为模型组(28只)、假手术组(6只)。造模成功后将24只模型鼠随机分为非那雄胺与多沙唑嗪联用、非那雄胺、多沙唑嗪组、阴性对照组,继续予皮下注射丙酸睾酮4mg/d.kg造模,连续4周;假手术组继续予皮下注射等量橄榄油4周。各组实验鼠分别于注射4周后处死,取出前列腺,光镜下观察其形态学变化,计算各实验组前列腺指数(PI)。免疫组化检测bax、fas、bcl-2蛋白表达情况。结果:与阴性对照组相比,给药4周后非那雄胺与多沙唑嗪联用、非那雄胺组PI、bcl-2表达下降(P<0.05),bax、fas表达增加(P<0.05)。结论:两种药物联用显著地降低了鼠前列腺增生的进展,有望成为临床治疗前列腺增生的新方法。     

双胶膏免疫调节作用的实验研究

运用淋巴细胞体外培养技术观察双胶膏的免疫作用．结果显示其能刺激T细胞有丝分裂，使T细胞增殖，对B细胞无作用。应用“氢考”造成的免疫抑制动物模型进行双胶膏对免疫功能影响实验，表明其对“氢考”造成的白细胞、血红蛋白量下降有一定的复原作用；能提高“氢考”模型小鼠的Th、Ts细胞百分率；一定程度地抵抗胸腺萎缩．     

Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊) in Treating Patients of Chronic Hepatitis B with Liver Cirrhosis

Objective: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Methods: Sixty-three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type Ⅳ (C-Ⅳ) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. Results: The liver cirrhosis indexes, HA, C-Ⅳ and LN, were improved significantly in the treated group after treatment, P<0.05. The liver function improvement rate in the treated group and the control group was 90.3% and 66.7% respectively, comparison of the two groups showed insignificant difference, P>0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8% and that on liver fibrosis stage was 75.6%, which were significantly improved as compared with those before treatment (P<0.05 and P<0.01), while in the control group, no significant improvement was found after treatment (P>0.05). Conclusion: QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively.     

痹痛灵胶囊治疗风湿性关节炎

目的 探讨痹痛灵胶囊抗风湿镇痛的临床效果。方法 56例活动期风湿性关节炎患者采用痹痛灵胶囊治疗，并作治疗前后对照研究。结果 主要症状、体征如关节疼痛指数、功能障碍指数、关节肿胀指数、双手握力、15m距离行走时间等均较治疗前明显改善（P＜0．01）；各项理化指标如ESR，ASO，IgG,IgA与治疗前相比有明显的好转（P＜0．01）。总有效率为100％。副作用轻微。结论 痹痛灵胶囊对风湿性关节炎有明显疗效，无明显副作用。     

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目的 探讨新生儿横结肠双腔造口术并发症的原因和防治措施。方法 对３７例新生儿横结肠双腔造口术进行随访。结果 除２例死亡外，造口周围皮炎３１例，造口粘膜炎性息肉１９例，造口狭窄４例，造口肠脱出４例，粘连性肠梗阻２例，误将乙状结肠作横结肠造口２例。结论 并发症常由于术中自理不当或术后护理不当而引起，并提出了防治措施。     

因需施教在临床实习带教中的体会

因需施教作为一种以临床常规需要为目标而对实习结果进行质量控制的教学方法,符合临床医疗教学的独特规律,是一种有效的教学方法。