乳腺微创旋切系统置管引流对治疗产褥期乳房多发脓肿的优势

目的:探讨采用乳腺微创旋切系统置管引流治疗产褥期多发乳房脓肿的临床效果。方法:研究采用回顾性分析方法对2014年1月-2017年12月34例产褥期乳房多发脓肿患者的诊治经过进行分析,其中采用乳腺微创旋切系统置管引流治疗患者17例(微创置管组),传统手术切开引流患者17例(切开组),对比两组患者治疗期间相关指标及术后效果差异。结果:微创置管引流组手术时间(28.28±7.25)min与切开引流组无明显差异。微创置管引流组术后疼痛程度(2.11±1.69)分、脓腔愈合时间(8.73±2.33)天、切口瘢痕长度(2.8±0.7)mm及继续哺乳率与切开引流组有明显差异,且差异具有统计学意义(P0.05)。结论:乳腺微创置管引流治疗产褥期乳房多发脓肿创伤小,愈合快,手术瘢痕不明显,不影响乳房外观,继续哺乳率高,是患者治疗产褥期多发乳房脓肿的较好的方法。     

乳核内消液辅助乳腺癌术后化疗对患者临床疗效、生活质量的影响

目的:探讨乳核内消液辅助乳腺癌手术后化疗对患者疗效、化疗毒副作用及生存质量的影响。方法:107例乳腺癌术后实施化疗的患者分为试验组和对照组,各53例,两组患者均与乳腺癌手术后化疗,试验组同时采用乳核内消液进行辅助治疗,观察两组预后、化疗过程中的毒副作用及随访期间的生存质量差异。结果:两组3年生存率、5年生存率、5年生存中位时间比较差异均不具有统计学意义(P>0.05)。试验组血液系统毒性发生率、心脏毒性发生率均显著低于照组(P<0.05)。试验组躯体功能评分、认知功能评分、情绪功能评分均显著的高于对照组(P<0.05);试验组疲劳症状评分、恶心及呕吐评分、疼痛评分均显著低于对照组(P<0.05)。结论:乳核内消液辅助乳腺癌手术后化疗对患者的远期预后影响作用尚不明显,但对患者的毒副反应及生存质量改善具有积极作用。     

盐霉素联合脐血间充质干细胞干预对乳腺癌MCF-7细胞的影响及作用机制

BACKGROUND:Mesenchymal stem cells-released factors can form a microenvironment inhibiting malignant tumor cell proliferation, and moreover, salinomycin also inhibits the growth of tumor cells. OBJECTIVE:To explore the effect of salinomycin with umbilical cord blood mesenchymal stem cells in breast cancer MCF-7 cells and its action mechanism, in order to seek a new target and therapeutic strategy to treat breast cancer. METHODS:Logarithmically growing MCF-7 cells were randomly divided into control, umbilical cord blood mesenchymal stem cell group and combination group. Cells in the control group were given no treatment, while those in the other two groups were given umbilical cord blood mesenchymal stem cell suspension or umbilical cord blood mesenchymal stem cell suspension combined with salinomycin, respectively. RESULTS AND CONCLUSION:Forty-eight hours after the intervention, the proliferation and invasion of MCF-7 cells and expression of POSTN protein in cells were significantly reduced in the combination group compared with the other two groups. These findings indicate that the combination of umbilical cord blood mesenchymal stem cell suspension and salinomycin effectively reduces the proliferation and migration of MCF-7 cells, and this combined use provides a new insight into the treatment of breast cancer.     

女性乳腺癌发病危险因素的病例-对照研究

目的 通过病例-对照研究探索女性乳腺癌的危险因素,为制定乳腺癌预防措施提供科学依据.方法 选取1148例初诊的乳腺癌患者作为病例组,根据年龄和月经史按1:2频数匹配健康对照2229例,收集两组的人口学特征资料和体重指数(BMI)、治疗前雌二醇(E2)检测结果,采用单因素和多因素Logistic分析乳腺癌的危险因素.结果 病例组绝经患者占40.59%,对照组绝经者占39.08%.单因素分析中,妊娠、生育、流产、哺乳次数多,初潮年龄晚者,罹患乳腺癌风险降低(P<0.05);BMI越高,罹患乳腺癌的风险越高(P<0.05);而E2水平与罹患乳腺癌风险无关(P>0.05).非条件Logistic多元回归分析显示,初潮年龄、妊娠次数、生育次数均为保护因素.结论 女性乳腺癌发病与月经、生育史有关.妊娠或生育均为乳腺癌的保护因素,初潮年龄越早,罹患乳腺癌的风险越高.