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1.
隐翅虫皮炎的地区性流行,在国内已有报道[1,2],我站于1997年9月对我县职业教育中心学校(以下简称“职教中心”)迁校后发生隐翅虫皮炎流行进行了一次全面的流行病学调查,报道如下。1对象与方法1.1对象:均为职教中心在新校址的全体在校学生和教职工及其家属;年龄7-49岁,平均18.2岁。1.2方法:按统一表格填写,内容包括班级、姓名、性别、年龄、居住楼层、发病日期、症状和皮报表现、形态、分布等。数据资料用f检验和U检验进行统计学处理。1.3学校环境调查:该校分两处,新校舍尚未竣工,位于我县律洋口镇农场内,当时刚迁入,… 相似文献
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Objective To investigate the effects of diazoxide preconditioning combined with hypothermia on the expression of Bcl-2 and Bax during anoxia-reoxygenation in rat hippocampal neurons. Methods The hippocampal neurons isolated from newborn SD rats ( < 24 h, weighing 5-6 g) were inoculated in the culture dish or 96 well plates. The hippocampal neurons were randomly assigned into 8 groups and each group contained 36 wells or 12 dishes of neurons: normal temperature .group (group NT), diazoxide preconditioning (DP) + NT group (group DP+ NT), mild hypothermia group (group MiH) , DP + MiH group (group DP + MiH) , moderate hypothermia group (group MoH), DP + MoH group (group DP + MoH), deep hypothermia group (group DeH) and DP+DeH group (group DP+ DeH). In group DP + NT, DP + MiH, DP+ MoH and DP + DeH, diazoxide was added to the culture media, the final concentration was 100 μmol/L,and the neurons were incubated for 1 h once a day for 2 d, and then subjected to 4 h of hypoxia at 37, 34, 30 and 22℃ , respectively, followed by 48 h of reoxygenation at 37℃ . The neuronal viability, apoptotic rates and expression of Bcl-2 and Bax were determined and the ratio of Bcl-2/Bax was calculated. Results The neuronal viability was significantly higher, apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP + NT, MiH, MoH and DeH than in group NT ( P < 0.05). The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP + MiH, DP + MoH and DP+ DeH than in group DP + NT ( P < 0.05), but there was no significant difference in the late apoptotic rate between group DP + MiH, DP + MoH, DP + DeH and DP + NT ( P > 0.05). The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP+ MiH and DeH than in group MiH (P < 0.05), but there was no significant difference in the late apoptotic rate between group DP + MiH, DeH and MiH, and no significant difference in the above indices between group MoH and MiH (P > 0.05) . The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP+ DeH than in group DP+ MiH ( P < 0.05). Conclusion Diazoxide preconditioning combined with hypothermia can attenuate the anoxia-reoxygenation injury in rat hippocampal neurons possibly through correcting the imbalance of Bcl-2 and Bax and inhibiting the early apoptosis of hippocampal neurons. 相似文献
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目的观察在无痛肠镜检查中伍用阿托品的安全性、可行性和不良反应情况。方法 80例ASAⅠ~Ⅱ级拟行无痛肠镜检查的患者,随机均分为两组:实验组(A组:异丙酚+芬太尼+阿托品组),对照组(C组:生理盐水+异丙酚+芬太尼组),观察两组各时期麻醉效果,平均动脉压(MBP)、心率(HR)、呼吸频率(RR)、SpO2变化;不良反应情况和内镜医师的满意度。结果两组患者麻醉效果(诱导时间、清醒时间、体动发生率)差异无统计学意义。与诱导前相比,C组患者给药诱导后SBP明显下降,HR减慢,RR变慢变浅,SpO2下降,差异有统计学意义(P〈0.05);A组无显著差别;与C组比较,A组不良反应少,内镜医师满意度高。结论在无痛肠镜检查中伍用阿托品能提供满意的麻醉效果,且不良反应少,内镜医师满意度高,值得推广应用。 相似文献
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Objective To investigate the effects of diazoxide preconditioning combined with hypothermia on the expression of Bcl-2 and Bax during anoxia-reoxygenation in rat hippocampal neurons. Methods The hippocampal neurons isolated from newborn SD rats ( < 24 h, weighing 5-6 g) were inoculated in the culture dish or 96 well plates. The hippocampal neurons were randomly assigned into 8 groups and each group contained 36 wells or 12 dishes of neurons: normal temperature .group (group NT), diazoxide preconditioning (DP) + NT group (group DP+ NT), mild hypothermia group (group MiH) , DP + MiH group (group DP + MiH) , moderate hypothermia group (group MoH), DP + MoH group (group DP + MoH), deep hypothermia group (group DeH) and DP+DeH group (group DP+ DeH). In group DP + NT, DP + MiH, DP+ MoH and DP + DeH, diazoxide was added to the culture media, the final concentration was 100 μmol/L,and the neurons were incubated for 1 h once a day for 2 d, and then subjected to 4 h of hypoxia at 37, 34, 30 and 22℃ , respectively, followed by 48 h of reoxygenation at 37℃ . The neuronal viability, apoptotic rates and expression of Bcl-2 and Bax were determined and the ratio of Bcl-2/Bax was calculated. Results The neuronal viability was significantly higher, apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP + NT, MiH, MoH and DeH than in group NT ( P < 0.05). The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP + MiH, DP + MoH and DP+ DeH than in group DP + NT ( P < 0.05), but there was no significant difference in the late apoptotic rate between group DP + MiH, DP + MoH, DP + DeH and DP + NT ( P > 0.05). The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP+ MiH and DeH than in group MiH (P < 0.05), but there was no significant difference in the late apoptotic rate between group DP + MiH, DeH and MiH, and no significant difference in the above indices between group MoH and MiH (P > 0.05) . The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP+ DeH than in group DP+ MiH ( P < 0.05). Conclusion Diazoxide preconditioning combined with hypothermia can attenuate the anoxia-reoxygenation injury in rat hippocampal neurons possibly through correcting the imbalance of Bcl-2 and Bax and inhibiting the early apoptosis of hippocampal neurons. 相似文献
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落实转诊和追踪工作是实施肺结核病人归口管理的关键环节,是实施现代结核病控制DOTS策略的基础[1].长阳县为了探索提高肺结核病人转诊和追踪到位率的方法,自2009年9月起在全县实施卫生行政干预,促进了综合医院、乡镇卫生院对肺结核/疑似肺结核病人网报、转诊及结防机构对转诊未到位病人的追踪工作,取得明显效果. 相似文献
9.
Objective To investigate the effects of diazoxide preconditioning combined with hypothermia on the expression of Bcl-2 and Bax during anoxia-reoxygenation in rat hippocampal neurons. Methods The hippocampal neurons isolated from newborn SD rats ( < 24 h, weighing 5-6 g) were inoculated in the culture dish or 96 well plates. The hippocampal neurons were randomly assigned into 8 groups and each group contained 36 wells or 12 dishes of neurons: normal temperature .group (group NT), diazoxide preconditioning (DP) + NT group (group DP+ NT), mild hypothermia group (group MiH) , DP + MiH group (group DP + MiH) , moderate hypothermia group (group MoH), DP + MoH group (group DP + MoH), deep hypothermia group (group DeH) and DP+DeH group (group DP+ DeH). In group DP + NT, DP + MiH, DP+ MoH and DP + DeH, diazoxide was added to the culture media, the final concentration was 100 μmol/L,and the neurons were incubated for 1 h once a day for 2 d, and then subjected to 4 h of hypoxia at 37, 34, 30 and 22℃ , respectively, followed by 48 h of reoxygenation at 37℃ . The neuronal viability, apoptotic rates and expression of Bcl-2 and Bax were determined and the ratio of Bcl-2/Bax was calculated. Results The neuronal viability was significantly higher, apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP + NT, MiH, MoH and DeH than in group NT ( P < 0.05). The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP + MiH, DP + MoH and DP+ DeH than in group DP + NT ( P < 0.05), but there was no significant difference in the late apoptotic rate between group DP + MiH, DP + MoH, DP + DeH and DP + NT ( P > 0.05). The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP+ MiH and DeH than in group MiH (P < 0.05), but there was no significant difference in the late apoptotic rate between group DP + MiH, DeH and MiH, and no significant difference in the above indices between group MoH and MiH (P > 0.05) . The neuronal viability was significantly higher, early apoptotic rate lower, Bcl-2 expression higher, Bax expression lower and Bcl-2/Bax ratio higher in group DP+ DeH than in group DP+ MiH ( P < 0.05). Conclusion Diazoxide preconditioning combined with hypothermia can attenuate the anoxia-reoxygenation injury in rat hippocampal neurons possibly through correcting the imbalance of Bcl-2 and Bax and inhibiting the early apoptosis of hippocampal neurons. 相似文献
10.
刘荣国 《公共卫生与预防医学》1997,8(3):52-53
一、临床资料患者,男,20岁,系长阳县航运公司水手,在长江中下游从事货物运输,工龄1年余。患者于1月前不明原因突起发热,体温多在39.5℃以上,呈猪留热型,伴消瘦、乏力,精神、食欲极差。于3日前出现腹痛、腹泻,呈钝痛,以左下腹为主,大便初为稀便,继为粘液脓血便,量少,伴里急后重,伴做咳,少痰,无血丝,否认近期有皮炎及尊麻疹史。在当地治疗无效,于1996年9月5日来我站就诊。既往有“肺结核”病史。体格检查:T39.8℃,R24次份,P113欢呼,邱14用KPa。神志清楚,轻度贫血貌,双肺呼吸音稍粗,腹软,左下腹轻压病,无反跳… 相似文献