盆腔输卵管病变对体外受精-胚胎移植妊娠结局的影响

目的 探讨盆腔输卵管不同病变对体外受精-胚胎移植(IVF-ET)妊娠结局的影响.方法 将1032例行IVF-ET患者分为盆腔输卵管病变组(605例)和非盆腔输卵管病变组(427例).盆腔输卵管病变组患者再根据输卵管病变部位不同分为输卵管阻塞组(243例)、输卵管切除组(104例)、输卵管造口组(149例)、输卵管积水组(109例);再根据是否合并盆腔病变分为合并盆腔病变组(194例)、非合并盆腔病变组(411例).对各组患者的临床妊娠、异位妊娠、自然流产情况进行回顾性分析.结果 盆腔输卵管病变组异位妊娠率和自然流产率[10.63%(27/254)和9.06%(23/254)]高于非盆腔输卵管病变组[3.27%(5/153)和4.58%(7,153)](P<0.01或<0.05).输卵管切除组异位妊娠率最低[2.17%(1/46)],输卵管造口组最高[22.41%(13/58)],各组比较差异有统计学意义(P<0.01).输卵管造口组和输卵管积水组自然流产率[10.34%(6/58)和15.00%(6/40)]明显高于输卵管阻塞组和输卵管切除组[7.27%(8/110)和6.52%(3/46)](P<0.05).合并盆腔病变组自然流产率[11.54%(9/78)]高于非合并盆腔病变组[7.95%(14/176)](P<0.05).结论 盆腔输卵管病变是发生异位妊娠及自然流产的高危因素,应加强IVF-ET术前对盆腔输卵管情况的评估与治疗.

Abstract：

Objective To evaluate the effect of the pathological changes of the pelvic cavity and fallopian tube on the outcome of in vitro fertilization and embryo transfer(IVF-ET).Method One thousand and thirty-two patients who underwent IVF-ET were divided into tubal and pelvic infertile group(605 cases)and non-tubal and pelvic infertile group(427 cases).The tubal and pelvic infertile group was also divided into salpingemphraxis group(243 cases),tubal resection group(104 cases),fallostomy group(149 cases),tubal dropsy group(109 cages)according to the tubal lesion regions,and combined with pelvic group(194 cases),combined without pelvic group(411 cases).The data of clinical pregnancy,ectopic pregnancy,and abortion was analyzed respectively.Results The ectopic pregnancy and abortion rates in tubal and pelvic infertile group[10.63%(27/254)and 9.06%(23/254)]were higher than those in non-tubal and pelvic infertile group [3.27%(5/153)and 4.58%(7/153)](P<0.01 or<0.05).The ectopic pregnancy rate was the lowest in tubal resection group[2.17%(1/46)],the highest in fallostomy group[22.41%(13/58)],there was significant difference among the groups(P<0.01).The abortion rate in fallostomy group and tubal dropsy group[10.34%(6/58)and 15.00%(6/40)]was higher than that in salpingemphraxis group and tubal resection group [7.27%(8/110)and 6.52%(3/46)],there was significant difference among the groups(P<0.05).The abortion rate in combined with pelvic group[11.54%(9/78)]was higher than that in combined without pelvic group[7.95%(14/176)](P<0.05).Conclusions The pathological changes of the pelvic cavity and fallopian tube are higher risk factors of ectopic pregnancy and abortion occurrence.The assessment and treatment of pelvic cavity and fallopian tube before assisted reproductive treatment cycles should be enhanced.