MYOCARDIAL ENZYME LEAKAGE AND SUCCINIC DEHYDROGENASE ACTIVITY OF MITOCHONDRIA CORRELATED WITH MORPHOLOGICAL CHANGES IN THE ANOXIC ISOLATED PERFUSED RAT HEART

Langendorff isolated perfused rat heart system was used to study the myocardial enzyme leakage and succinic dehydrogenase activity of mitochondria, and to investigate their correlation with the morphological changes due to anoxia-induced injury. 84 male Wistar rats were used and divided into the aerobic control group and the anoxic group. Besides the mitochondrial structural changes and the myccardial cell menbrane permeabilily defects observed, the SDH activity of mitcchondria was reduced and the CPK release increased. The morphological, functional and biochemical changes in anoxic rat heart correlated with each other very well.     

实验性肥大心肌对阿霉素毒性易感性的观察

阿霉素是目前抗肿瘤较有效的药物之一,但它能引起心肌损伤,在高血压、心肌负荷过大患者中易引起阿霉素中毒性心肌病。本实验用电镜、生化方法观察大鼠实验性肥大心肌对阿霉素毒性易感性增加的原     

老年人二尖瓣粘液样变性

二尖瓣粘液样变性(Mitral Valve My-xomatous Degeneration,MVMD)系引起二尖瓣脱垂(Mitral Valve Prolapse,MVP)之最常见原因,临床上主要表现为收缩中期喀喇音及收缩晚期杂音(俗称之为:喀喇音—杂音综合征)。六十年代伊始,发现本病多见于年青女性,Framingh-am普查资料表明,年轻女性占20%.目前认为本病并非罕见.随着人群平均寿命的增长及临床诊疗手段的提高,老年人中发现本病愈来愈多.其重要性在于本病可导致瓣膜本身及其瓣环结构损害,甚至引起腱索断裂。这可能是引起老年人二尖瓣关闭不全而需外     

动脉粥样硬化的防治研究进展

动脉粥样硬化(AS)的防治研究日益引起重视。本文拟就其最新进展予以简述.改善脂质代谢改善脂质代谢的途径有三:药物治疗,手术疗法及饮食控制。一、药物疗法:AS 病变的显著特征是脂质的浸润和沉积.数十年来,人们一直认为处理高脂血症乃本病防治之重要措施.然而,近年来的研究表明:血浆脂蛋白与 AS 的关系异常复杂,血浆总胆固醇(TC)高者未必发生 AS,反之,血浆 TC 正常者未必不易发生 AS;此外,Miller 已证实高密度脂蛋白(HDL)