Therapeutic Effect of Dimethyl Dimethoxy Biphenyl Dicarboxylate on Collagen-Induced Arthritis in Rats

Objective:To study the effect of oral administration of dimethyl dimethoxy biphenyl dicarboxylate(DDB) on adjusting angiogeneic/inflammatory mediators and ameliorating the pathology of bones in rats with collagen-induced arthritis(CIA).Methods:Wistar rat model of CIA was set up using bovine collagen type Ⅱ.Fifty rats were divided into five groups randomly:normal,CIA model,DDB treatment,methotrexate(MTX) treatment,and combined DDB+MTX treatment.Ankle joints of rats were imaged with digital X-ray machine to show the destruction of joints.Fore and hind paw and knee joints were removed above the ankle joint then processed for haematoxylin and eosin staining.Plasma levels of vascular endothelial growth factor(VEGF),platelet derived growth factor,interleukin-8(IL-8),IL-4,tumor necrosis factor α(TNF-α),and cyclooxygenase-2(COX-2) were quantified by enzyme-linked immunosorbent assay.Nitric oxide levels were detected by Griess reagent.Results:Compared with the CIA model group,a remarkable reduction in various angiogenic(VEGF and IL-8) and inflammatory mediators(TNF-α,IL-4 and COX-2) after treatment with DDB either alone or combined with MTX(P0.05 or P0.01).Histopathological and X-ray findings were confirmatory to the observed DDB anti-arthritic effect.The DDB-treated group showed amelioration in signs of arthritis which appeared essentially similar to normal.Conclusion:Our data shed light on the therapeutic efficacy of DDB in experimental rheumatoid arthritis(RA) compared with a choice drug(MTX) and it may be offered as a second-line drug in the treatment of RA.     

Transplantation of an eight-organ multivisceraI graft in a patient with frozen abdomen after complicated Crohn's disease

To report an extended multivisceral transplantation (MVTx) including right kidney and ascending colon in a patient with complicated Crohn's disease (CD). A 36-year old female suffering from short bowel syndrome and frozen abdomen due to fistulizing CD after multiple abdominal operations underwent MVTx of eight organs including stomach, pancreatoduodenal complex, liver, intestine, ascending colon, right kidney, right adrenal gland, and greater omentum in November 2003. Immunosuppression consisted of alemtuzumab, tacrolimus and steroids. The patient was off parenteral nutrition by postoperative wk 3. She experienced one episode of pneumonia. The patient recovered completely and discharged 2.5 mo and was doing well 30 mo after MVTx. This is one of the very rare cases in which a complete mulitivisceral graft of eight abdominal organs was transplanted orthotopically.     

伴Leiden V因子突变和狼疮抗凝物的恶性萎缩性丘疹病（Degos病）死亡1例

恶性萎缩性丘疹病（Degos病）是一类非常罕见的疾病，其皮损特点是萎缩性丘疹和多种系统症状。作者描述了1例33岁的男性患者，其表现为泛发性皮损，与恶性萎缩性丘疹病的体征一致。患者病程中甚至发生阴茎溃疡，此症状以往仅有少数报道。患者发病2．5年后死于小肠复穿孔。实验室检查显示Leide nV因子突变和狼疮抗凝物的出现，但未发现抗心肌磷脂抗体。患者先后接受了窄波紫外线（UV）、强的松龙和阿司匹林、己酮可可碱、华法林的治疗。尽管接受了这种强抗凝血和抗血小板治疗，患者皮损和系统症状仍未得到改善。     

应用二甲双胍长期及短期治疗调节多囊卵巢综合征妇女的月经周期效果

本回顾性研究旨在比较两组多囊卵巢综合征患者的月经周期频率:应用二甲双胍治疗3～6个月及>6个月的妇女。结果显示二甲双胍在调节多囊卵巢综合征妇女的月经周期正常方面疗效显著(全部反应率为69%,获得正常周期者反应率为88%),在治疗持续6个月或更长的患者中疗效更显著(二甲双胍     

玻璃体腔内注射高纯度绵羊透明质酸酶治疗玻璃体出血的两项Ⅲ期安全性试验结果

目的:评价玻璃体腔内注射高纯度绵羊透明质酸酶治疗玻璃体出血的安全性。设计:两项前瞻性、随机化、安慰剂对照的双盲研究(相关数据资料见本期同发的文章)。方法:受试者在纳入时的玻璃体出血均在1个月以内,病情严重受试眼的最佳矫正视力(BCVA)<20/200,随机予以7.5U、55U、75U的     

浴光疗同步治疗对不同类型银屑病均有效

背景:浴光疗同步治疗银屑病的有效性与UVB和死海盐的多靶点作用有关,同步治疗能够起到协同功效。目的:本回顾性研究的目的:①评价浴光疗同步治疗各种临床类型银屑病的有效性;②观察治疗反应有无不同;③获得更多数据以预测对不同类型银屑病的治疗效果,以便针对患者的类型选择治疗效果良好的方法。方法:根据Regensburg计划,患者接受了一个包括35次治疗的基础同步浴光疗疗程,随后又接受了一个包括25次治疗的维持治疗疗程。治疗中每周进行PASI评分以评价患者的皮肤状态。对373例按计划完成基础疗程的患者和其中78例完成维持疗程的患者的治疗…     

正常妊娠脉波速率的变化及其在预测妊娠期高血压疾病中的价值:一项纵向研究

目的:纵向观察整个妊娠期从臂到踝脉波速率(PW V)可扩张性的变化及其在正常妊娠与妊娠期高血压(PIH)患者之间的差异。研究设计:183例孕妇纳入本研究。分别在妊娠早期、妊娠中期、妊娠晚期、产后即刻及产后1个月测定PW V。结果:正常妊娠组妊娠中期PW V显著降低,从晚期妊娠到产后     

脑内出血后使用抗血小板药物的评价

背景:脑内出血存活者出现复发性脑内出血和缺血性心脑血管疾病的风险升高。目的:确定抗血小板治疗是否会增加脑内出血复发的风险。方法:对一项单中心的前瞻性队列研究中的原发性脑内出血连续存活者的资料进行回顾性分析。存活者接受电话随访,记录其复发性脑内出血和发病后的抗血小板药物使用情况及其持续时间。利用Cox比例风险模型,将抗血小板药物使用作为时间依赖性变量,根据脑叶和深层半球定位分层来评价使用抗血小板药物对复发性脑内出血的影响。结果:与深层出血的存活者相比,脑叶出血存活者的复发性脑内出血更常见(2年累积发生率22%vs4…     

老年患者冠状动脉血运重建术后的生活质量

目的:描述一组老年心脏病患者队列在4年后的健康状况。方法和结果:Alberta省冠心病预后评价项目(APPRO ACH)是一项纳入所有在加拿大Alberta省接受心导管检查的患者的预后评估计划,对这些患者用西雅图心绞痛调查量表(SAQ)进行健康状况评估,对经皮冠状动脉介入或冠状动脉搭桥手术     

1例马方综合征患者眼部表现的不对称色素性青光眼

背景:目前眼科文献中还没有报道过马方综合征与色素性青光眼之间的关系。本研究描述了1例马方综合征患者出现双眼色素弥散及不对称性青光眼。方法:1例34岁的马方综合征患者出现了双眼色素弥散。在右眼,眼内压升高与显著的青光眼形视盘凹陷及对应的视野缺损相一致。右眼虹膜6点位出现局限性带状裂开。结果:超声生物显微镜检查显示右眼虹膜有明显的虹膜凹,晶状体上方半脱位导致虹膜-晶状体接触面增加,同时导致单侧色素弥散加剧。这一结构解释了青光眼损害的不对称性。结论:色素性青光眼的不对称性进展较为罕见,因此应该进行进一步的探查以找到…