Clinico-morphological changes in a burn wound after electric stimulation with pulsatile current

The healing of sluggishly postburn wounds after local electrostimulation (ES) with the use of current-conducting carbon tissue as the electrode was studied in 12 patients. Analysis of the clinical data which were corroborated by the results of morphological and biochemical studies confirmed the marked stimulating effect of local ES which facilitates successful taking of dermal autografts and healing of burn wounds. The obtained data are evidence that the method of ES through a current-conducting carbon tissue is promising in the complex of measures for local treatment of burn wounds.     

Results of the use of a graft with a monocusp in radical correction of Fallot's tetrad

The article deals with the results of complex study of the effect of pulmonary insufficiency on intracardiac hemodynamics and function of the heart in the immediate and late-term periods after radical correction of Fallot's tetralogy. Answers are also given to questions concerning the expediency of the use and functional adequacy of a xeno-pericardial monocusp in the closure mechanism of the pulmonary artery valve. The study showed that massive pulmonary regurgitation has a negative effect on the functional condition of the right ventricle in late-term postoperative periods. Convincing data were obtained which allow a graft with a monocusp of a bull's pericardium to be recommended for further clinical use to prevent insufficiency of the pulmonary artery valve after radical correction of Fallot's tetralogy.     

Pharmacokinetics of ximedone

Optimum conditions for the spectrophotometric determination of pyrimidine derivatives in biological fluids of humans are determined. This method has been used for the investigation of the pharmacokinetics of the new immunomodulant ximedone in humans, dogs, and rats upon administration of the drug in different ways. Interspecific relationships of the key parameters of ximedone pharmacokinetics are established. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 7, pp. 5–8, July, 2006.     

Effect of the immunomodulant ximedone on the pharmacokinetics of isonicotinic acid hydrazide in the human organism

The pharmacokinetics of isonicotinic acid hydrazide upon joint administration with the immunomodulant ximedone has been investigated. Ximedone influences the genetically determined parameters of the isonicotinic acid hydrazide pharmacokinetics. The dose-dependent and temporal schedules of ximedone administration in humans are established, which favor the induction of acetylation processes in patients. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 3–6, March, 2006.     

Venous hemodynamics in chronic occlusive diseases of arteries of the lower extremities

The authors have revealed a gradual development of venous hypertension and deceleration of the rate of venous blood flow in the damaged extremities in chronic obliterative arterial diseases. Decompensation of arterial hemodynamics is accompanied by the development of pronounced venous congestion with reduced venous pressure and tension. This may cause the incompetence of the deep venous valves.