全文获取类型
收费全文 | 7319篇 |
免费 | 551篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 61篇 |
儿科学 | 136篇 |
妇产科学 | 42篇 |
基础医学 | 1018篇 |
口腔科学 | 144篇 |
临床医学 | 521篇 |
内科学 | 2044篇 |
皮肤病学 | 99篇 |
神经病学 | 366篇 |
特种医学 | 257篇 |
外科学 | 1275篇 |
综合类 | 33篇 |
一般理论 | 2篇 |
预防医学 | 173篇 |
眼科学 | 113篇 |
药学 | 442篇 |
中国医学 | 12篇 |
肿瘤学 | 1180篇 |
出版年
2024年 | 7篇 |
2023年 | 138篇 |
2022年 | 254篇 |
2021年 | 482篇 |
2020年 | 241篇 |
2019年 | 309篇 |
2018年 | 357篇 |
2017年 | 284篇 |
2016年 | 308篇 |
2015年 | 297篇 |
2014年 | 328篇 |
2013年 | 345篇 |
2012年 | 534篇 |
2011年 | 595篇 |
2010年 | 297篇 |
2009年 | 235篇 |
2008年 | 434篇 |
2007年 | 385篇 |
2006年 | 327篇 |
2005年 | 282篇 |
2004年 | 289篇 |
2003年 | 256篇 |
2002年 | 229篇 |
2001年 | 74篇 |
2000年 | 69篇 |
1999年 | 90篇 |
1998年 | 68篇 |
1997年 | 63篇 |
1996年 | 43篇 |
1995年 | 39篇 |
1994年 | 34篇 |
1993年 | 31篇 |
1992年 | 27篇 |
1991年 | 14篇 |
1990年 | 22篇 |
1989年 | 16篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 13篇 |
1984年 | 15篇 |
1983年 | 12篇 |
1982年 | 4篇 |
1980年 | 4篇 |
1976年 | 3篇 |
1974年 | 5篇 |
1972年 | 5篇 |
1971年 | 3篇 |
1968年 | 4篇 |
1967年 | 3篇 |
排序方式: 共有7918条查询结果,搜索用时 15 毫秒
1.
2.
Hiroto Kinoshita Hitomi Nishioka Aya Ikeda Kyoko Ikoma Yoichi Sameshima Hidehisa Ohi Mizuki Tatsuno Junka Kouyama Chiaki Kawamoto Tomohiro Mitsui Yuko Tamura Yu Hashimoto Masashi Nishio Tsuyoshi Ogashiwa Yusuke Saigusa Shin Maeda Hideaki Kimura Reiko Kunisaki Kazuhiko Koike 《Journal of gastroenterology and hepatology》2019,34(11):1929-1939
3.
4.
5.
Marie Ohata Susumu Fujiwara Ai Yoshioka Hiroshi Nagai Shintaro Sugita Nozomi Yamano Yusuke Inoue Chikako Nishigori 《Pediatric dermatology》2019,36(6):997-998
Fibroblastic connective tissue nevus (FCTN) is a benign cutaneous mesenchymal lesion characterized by proliferation of CD34‐positive fibroblastic/myofibroblastic spindle‐shaped cells. We report a case of agminated FCTN on the right lower abdomen of a 1‐year‐old boy. 相似文献
6.
7.
Blocking effect of 1389-S on the sodium current in isolated guinea-pig ventricular myocytes 总被引:2,自引:0,他引:2
I Hisatome S Matsuoka J Miyamoto M Sawaguchi H Omodani S Osaki H Kotake H Mashiba R Sato 《European journal of pharmacology》1990,179(3):447-451
Under whole cell patch conditions, 1389-S blocked the INa in guinea-pig ventricular myocytes under steady state conditions (Kdrest = 30 microM, Kdi = 2.4 microM) with a shift of the inactivation curve to the hyperpolarizing direction. Both brief and long conditioning pulses could produce a use-dependent block of 1389-S. These results suggest that 1389-S had a higher affinity to the inactivated than to the rested state under steady state conditions and had a higher affinity to the activated state during train pulses as well as to the inactivated state, making channels unavailable for conduction upon activation. 相似文献
8.
J Osaki H Nakano H Matsumoto Y Yamazaki H Sakai T Tsuji Y Osaki T Fujikane N Sasaki S Onodera 《Nihon Kyōbu Shikkan Gakkai zasshi》1992,30(6):1152-1157
We encountered a rare case of hypersensitivity pneumonitis associated with bilateral hilar lymphadenopathy (BHL). The patient was a 53-year-old male, who developed dry cough and shortness of breath when using a humidifier since 1982. He was admitted to our hospital for further evaluation in 1987. Chest X-ray films showed BHL and ground glass appearance in the bilateral lung fields. Pulmonary function test indicated disturbance of diffusing capacity. Transbronchial lung biopsy revealed interstitial pneumonitis, and lymph node biopsy by mediastinoscopy showed lymphoid sinus histiocytosis without noncaseating granuloma. Provocation test using the humidifier was positive, and the diagnosis of humidifier lung with BHL was made. 相似文献
9.
Hisashi Kai Takahiro Mori Keisuke Tokuda Narimasa Takayama Nobuhiro Tahara Kiyoko Takemiya Hiroshi Kudo Yusuke Sugi Daisuke Fukui Hideo Yasukawa Fumitaka Kuwahara Tsutomu Imaizumi 《Hypertension research》2006,29(9):711-718
Oxidative stress is implicated in the pathogenesis of various cardiovascular diseases. We have shown that in Wistar rats with a suprarenal aortic constriction (AC), pressure overload-induced transient perivascular inflammation (monocyte chemoattractant protein-1 [MCP-1] induction and macrophage accumulation) in the early phase is the determinant of reactive myocardial fibrosis and resultant diastolic dysfunction in the late phase. Thus, we investigated the role of reactive oxygen species production in cardiac remodeling in AC rats. Superoxide production and the footprint of lipid peroxidation were assessed using dihydroethidium staining and immunohistostaining against 4-hydroxy-2-nonenal (4-HNE), respectively. In sham rats, dihydroethidium and 4-HNE signals were scarcely found in the heart. At day 3, AC rats showed dihydroethidium signals mainly in the intramyocardial arterial wall, whereas modest 4-HNE staining was observed diffusely in the myocardium. These signals declined to lower levels by day 14 despite sustained hypertension. Chronic administration of a subdepressor dose of an angiotensin II type 1 receptor blocker candesartan reduced the pressure overload-induced dihydroethidium and 4-HNE signals at day 3. Moreover, candesartan decreased MCP-1 induction and macrophage infiltration at day 3 and prevented myocardial fibrosis at day 14, without affecting left ventricle and myocyte hypertrophy. In conclusion, acute pressure overload induced self-limited superoxide production mainly in the vascular wall. The reactive oxygen species production would contribute to the perivascular inflammation and subsequent myocardial fibrosis. Angiotensin II was suggested to have a pressure-independent effect on the reactive oxygen species production. 相似文献
10.
Takashi Akasaki Yusuke Ohya Junya Kuroda Kimika Eto Isao Abe Hideki Sumimoto Mitsuo Iida 《Hypertension research》2006,29(10):813-820
Although vascular cells express multiple members of the Nox family of nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase, including gp91phox, Nox1, and Nox4, the reasons for the different expressions and specific roles of these members in vascular injury in chronic hypertension have remained unclear. Thus, we quantified the mRNA expressions of these NAD(P)H oxidase components by real-time polymerase chain reaction and evaluated superoxide production and morphological changes in the aortas of 32-week-old stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched Wistar Kyoto rats (WKY). The aortic media of SHRSP had an approximately 2.5-fold greater level of Nox4 mRNA and an approximately 10-fold greater level of Nox1 mRNA than WKY. The mRNA expressions of gp91phox and p22phox in SHRSP and WKY were comparable. SHRSP were treated from 24 weeks of age for 8 weeks with either high or low doses of candesartan (4 mg/kg/day or 0.2 mg/kg/day), or a combination of hydralazine (30 mg/kg/day) and hydrochlorothiazide (4.5 mg/kg/day). The high-dose candesartan or the hydralazine plus hydrochlorothiazide decreased the blood pressure of SHRSP to that of WKY, whereas the low-dose candesartan exerted no significant antihypertensive action. Media thickening and fibrosis, as well as the increased production of superoxide in SHRSP, were nearly normalized with high-dose candesartan and partially corrected with low-dose candesartan or hydralazine plus hydrochlorothiazide. These changes by antihypertensive treatment paralleled the decrease in mRNA expression of Nox4 and Nox1. These results suggest that blood pressure and angiotensin II type 1 receptor activation are involved in the up-regulation of Nox1 and Nox4 expression, which could contribute to vascular injury during chronic hypertension. 相似文献