全文获取类型
收费全文 | 17168篇 |
免费 | 1027篇 |
国内免费 | 68篇 |
专业分类
耳鼻咽喉 | 198篇 |
儿科学 | 286篇 |
妇产科学 | 187篇 |
基础医学 | 2413篇 |
口腔科学 | 438篇 |
临床医学 | 1152篇 |
内科学 | 4126篇 |
皮肤病学 | 209篇 |
神经病学 | 1029篇 |
特种医学 | 1190篇 |
外科学 | 2815篇 |
综合类 | 86篇 |
一般理论 | 2篇 |
预防医学 | 385篇 |
眼科学 | 223篇 |
药学 | 1294篇 |
中国医学 | 27篇 |
肿瘤学 | 2203篇 |
出版年
2023年 | 166篇 |
2022年 | 267篇 |
2021年 | 609篇 |
2020年 | 306篇 |
2019年 | 402篇 |
2018年 | 504篇 |
2017年 | 378篇 |
2016年 | 438篇 |
2015年 | 429篇 |
2014年 | 486篇 |
2013年 | 566篇 |
2012年 | 845篇 |
2011年 | 996篇 |
2010年 | 527篇 |
2009年 | 455篇 |
2008年 | 789篇 |
2007年 | 768篇 |
2006年 | 728篇 |
2005年 | 729篇 |
2004年 | 725篇 |
2003年 | 690篇 |
2002年 | 637篇 |
2001年 | 485篇 |
2000年 | 493篇 |
1999年 | 477篇 |
1998年 | 212篇 |
1997年 | 167篇 |
1996年 | 159篇 |
1995年 | 121篇 |
1994年 | 106篇 |
1993年 | 92篇 |
1992年 | 341篇 |
1991年 | 297篇 |
1990年 | 310篇 |
1989年 | 333篇 |
1988年 | 290篇 |
1987年 | 293篇 |
1986年 | 244篇 |
1985年 | 247篇 |
1984年 | 163篇 |
1983年 | 107篇 |
1982年 | 58篇 |
1981年 | 48篇 |
1979年 | 77篇 |
1978年 | 69篇 |
1977年 | 65篇 |
1976年 | 45篇 |
1974年 | 60篇 |
1972年 | 56篇 |
1970年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
The present narrative review examines the scientific evidence of the biological mechanisms that may link periodontitis and diabetes, as a source of comorbidity. Publications regarding periodontitis and diabetes, in human, animals, and in vitro were screened for their relevance. Periodontal microbiome studies indicate a possible association between altered glucose metabolism in prediabetes and diabetes and changes in the periodontal microbiome. Coinciding with this, hyperglycemia enhances expression of pathogen receptors, which enhance host response to the dysbiotic microbiome. Hyperglycemia also promotes pro-inflammatory response independently or via the advanced glycation end product/receptor for advanced glycation end product pathway. These processes excite cellular tissue destruction functions, which further enhance pro-inflammatory cytokines expression and alteration in the RANKL/osteoprotegerin ratio, promoting formation and activation of osteoclasts. The evidence supports the role of several pathogenic mechanisms in the path of true causal comorbidity between poorly controlled diabetes and periodontitis. However, further research is needed to better understand these mechanisms and to explore other mechanisms. 相似文献
2.
3.
4.
Heterozygous nonsense mutations near the C‐terminal region of IGF1R in two patients with small‐for‐gestational‐age‐related short stature
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
6.
Hiroto Kinoshita Hitomi Nishioka Aya Ikeda Kyoko Ikoma Yoichi Sameshima Hidehisa Ohi Mizuki Tatsuno Junka Kouyama Chiaki Kawamoto Tomohiro Mitsui Yuko Tamura Yu Hashimoto Masashi Nishio Tsuyoshi Ogashiwa Yusuke Saigusa Shin Maeda Hideaki Kimura Reiko Kunisaki Kazuhiko Koike 《Journal of gastroenterology and hepatology》2019,34(11):1929-1939
7.
8.
9.
Marie Ohata Susumu Fujiwara Ai Yoshioka Hiroshi Nagai Shintaro Sugita Nozomi Yamano Yusuke Inoue Chikako Nishigori 《Pediatric dermatology》2019,36(6):997-998
Fibroblastic connective tissue nevus (FCTN) is a benign cutaneous mesenchymal lesion characterized by proliferation of CD34‐positive fibroblastic/myofibroblastic spindle‐shaped cells. We report a case of agminated FCTN on the right lower abdomen of a 1‐year‐old boy. 相似文献
10.
Katsuo Kamata Ayako Makino Noriyasu Kanie Shu-ichi Oda Takayuki Matsumoto Tsuneo Kobayashi Toyohiko Kikuchi Masato Nishimura Toshio Honda 《Journal of Smooth Muscle Research》2006,42(2-3):75-88
Anthocyanins, which are responsible for a variety of bright colors (including red, blue, and purple) in fruits, vegetables, and flowers, are consumed as dietary polyphenols. Anthocyanin-containing fruits are thought to decrease coronary heart disease and are used in anti-diabetic preparations. Diabetes is associated with a variety of cardiovascular complications that may be mediated by endothelial dysfunction, and so this study was designed mainly to characterize the influence of a synthesized anthocyanidin derivative (HK-008) over acetylcholine (ACh)-induced relaxation in mesenteric arterial beds isolated from rats. In a glucose-tolerance test in intact rats, HK-008 (30 mg/kg) reduced the glucose level as effectively as the same dose of glibenclamide. The aortic relaxation induced by pinacidil (an ATP-sensitive potassium channel opener) was greatly inhibited by glibenclamide (10 microM), and also significantly inhibited by HK-008 (10 microM). Interestingly, the ACh-induced relaxation in the perfused, preconstricted mesenteric arterial bed was significantly enhanced by HK-008 (10 microM), and this enhancement was significantly attenuated by indomethacin (10 microM). The ACh-induced mesenteric relaxation was impaired by an increase in oxidative stress, viz. superoxide-generating treatment [xanthine oxidase (XO; 0.1 U/ml) plus hypoxanthine (HX; 10 microM)]. However, this impairment was strongly suppressed by HK-008 (10 microM). These results suggest that HK-008 increases endothelium-induced relaxation by suppressing oxidative stress or modulating prostanoids signaling. This compound may therefore be useful against certain cardiovascular disorders. 相似文献