全文获取类型
收费全文 | 5181篇 |
免费 | 238篇 |
国内免费 | 62篇 |
专业分类
耳鼻咽喉 | 214篇 |
儿科学 | 75篇 |
妇产科学 | 46篇 |
基础医学 | 566篇 |
口腔科学 | 214篇 |
临床医学 | 339篇 |
内科学 | 1297篇 |
皮肤病学 | 66篇 |
神经病学 | 280篇 |
特种医学 | 237篇 |
外科学 | 811篇 |
综合类 | 34篇 |
预防医学 | 99篇 |
眼科学 | 160篇 |
药学 | 317篇 |
中国医学 | 12篇 |
肿瘤学 | 714篇 |
出版年
2023年 | 41篇 |
2022年 | 83篇 |
2021年 | 104篇 |
2020年 | 69篇 |
2019年 | 85篇 |
2018年 | 106篇 |
2017年 | 99篇 |
2016年 | 120篇 |
2015年 | 105篇 |
2014年 | 141篇 |
2013年 | 180篇 |
2012年 | 249篇 |
2011年 | 271篇 |
2010年 | 144篇 |
2009年 | 124篇 |
2008年 | 220篇 |
2007年 | 230篇 |
2006年 | 249篇 |
2005年 | 263篇 |
2004年 | 266篇 |
2003年 | 266篇 |
2002年 | 281篇 |
2001年 | 139篇 |
2000年 | 133篇 |
1999年 | 132篇 |
1998年 | 74篇 |
1997年 | 54篇 |
1996年 | 54篇 |
1995年 | 41篇 |
1994年 | 43篇 |
1993年 | 28篇 |
1992年 | 90篇 |
1991年 | 97篇 |
1990年 | 82篇 |
1989年 | 83篇 |
1988年 | 75篇 |
1987年 | 65篇 |
1986年 | 63篇 |
1985年 | 71篇 |
1984年 | 34篇 |
1983年 | 39篇 |
1981年 | 21篇 |
1979年 | 31篇 |
1978年 | 26篇 |
1977年 | 23篇 |
1975年 | 27篇 |
1974年 | 35篇 |
1973年 | 26篇 |
1972年 | 36篇 |
1971年 | 27篇 |
排序方式: 共有5481条查询结果,搜索用时 15 毫秒
1.
2.
3.
H Ogura H Kubota I Nomura T Tomoda K Araki Y Ogura T Kurashige 《The Japanese journal of antibiotics》1989,42(2):401-410
A new macrolide antibiotic, clarithromycin (TE-031, A-56268), was studied for its clinical efficacy in the field of pediatrics. Patients treated were infants and children ranging from 2 months to 11 years old suffering from acute bronchitis in 5 cases, acute tonsillitis in 2 cases, Mycoplasma pneumonia in 2 cases, pertussis in 6 cases, scarlatina in 1 case and acute enteritis in 2 cases, a total of 18 cases. TE-031 was administered 19.7-43.5 mg/kg in daily doses and lengths of treatment ranged from 4 to 19 days. As regards to its clinical efficacy, good or excellent results were obtained in all cases: excellent in 11 cases and good in 7 cases. No clinical side effects nor abnormal laboratory test values obviously attributable to TE-031 were observed. 相似文献
4.
For monitoring the changes in intracellular free Ca2+ concentration ([Ca2+]i), we developed a simple system combining a fluorescence microscope, an image intensifier, a video-camera, a cathode ray tube display and a photodiode, employing quin2 as a Ca2+ indicator. We recorded increases of the fluorescence intensity due to [Ca2+]i rises, when high K+ medium, neurotransmitter and Ca2+ ionophore were applied to the single cells of nervous system origin in culture. The present system is capable of simultaneous detection of the [Ca2+]i changes from multiple separate cells. 相似文献
5.
6.
Mana Ichimura Koichi Hiratsuka Naomi Ogura Tadahiko Utsunomiya Hiroyuki Sakamaki Toshirou Kondoh Yoshimitsu Abiko Shigeo Otake Masafumi Yamamoto 《Journal of oral pathology & medicine》2006,35(3):167-174
BACKGROUND: To understand the immunopathological features of oral lichen planus (OLP), we analyzed the expression of chemokines in the epithelial cell layers. Methods: Epithelia from OLP or healthy gingiva were collected by laser microdissection. The chemokine and chemokine receptor expressions in the epithelia were analyzed by DNA microarray. RESULTS: High levels of MIP-3alpha/LARC/CCL20 and its receptor CCR6 were expressed in the lesional epithelia. Furthermore, DC-CK1/CCL18, ELC/CCL19, SDF-1/CXCL12 and CXCR4 expressions were also increased. Immunohistologial analysis showed that high numbers of Langerhans cells (LCs) were present in the epithelia of OLP. Lesional epithelia also expressed high levels of the ligands specific for CXCR3 (e.g. MIG/CXCL9, IP-10/CXCL10 and I-TAC/CXCL11) and CCR5 (e.g. RANTES/CCL5). CONCLUSIONS: Infiltration of LCs is orchestrated by CCR6. Further, LCs residing in the lesional epithelia may be a mature phenotype. Moreover, infiltration of T cells in OLP could be mediated by signaling pathways through CXCR3 and CCR5. 相似文献
7.
Mikiko Ueda Fumitaka Oike Yasuhiro Ogura Kenji Uryuhara Yasuhiro Fujimoto Mureo Kasahara Kohei Ogawa Koichi Kozaki Hironori Haga Koichi Tanaka 《Liver transplantation》2006,12(9):1326-1336
This report concerns the long-term outcome of living donor liver transplantation (LDLT) for pediatric patients at a single center. Between June 1990 and December 2003, a total of 600 LDLTs, including 568 primary transplantations and 32 retransplantations, were performed for pediatric patients, who were immunosuppressed with FK506 and low-dose corticosteroids. Patient survival at 1, 5, and 10 years were 84.6%, 82.4%, and 77.2%, respectively, and the corresponding findings for graft survivals were 84.1%, 80.9%, and 74.5%. Multivariate analysis demonstrated that fulminant hepatic failure (FHF), a graft vs. body weight (GBWR) ratio of <0.8, and ABO-incompatible transplants were independently associated with both patient and graft survival. The retransplantation rate was 6%, and 55 patients (9.7%) have been completely weaned off immunosuppressants. Long-term patient and graft survival after pediatric LDLT for a large cohort of children at our hospital were found to be as good as those for cadaveric liver transplantation, although this series includes 13% liver transplantations with ABO-incompatible donors, which are obviously inferior in patient and graft survival. To obtain better outcomes for patients with FHF and for patients with ABO-incompatible transplants, immunosuppressive therapy needs to be improved. 相似文献
8.
Y Koyama Y Chinen H Ogura S Shishido I Higa T Hatano M Hayakawa A Osawa M Igarashi 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1990,81(8):1212-1216
Immunological studies were performed in 87 patients with chyluria referred to our clinic from January 1982 to December 1988. White blood cell count in 78 patients was 5210.3 +/- 1440.9/mm3. The fraction and the number of lymphocyte were 18.7 +/- 9.5% and 934.1 +/- 521.6/mm3, respectively: they were lower than normal limit. The percentages of T and B lymphocytes studied in 46 patients were 79.3% +/- 11.2% (normal range: 76-86) and 10.4 +/- 7.9% (normal range: 8-16), respectively: both lymphocytes tended to decrease in percentage. Lymphocyte blast formation stimulated with phytohemagglutinin (PHA) was carried out in 20 patients. The mean of the blast formation was 17410.0 +/- 10275.1 c.p.m. (normal range: 377700-62400), and much lower than normal value. Of 22 patients who had PPD skin test, only 9 (40.9%) were positive. These findings signified that cellular immunity was suppressed in patients with chyluria. On the other hand, the value of immunoglobulin was within normal range (IgG: 1325.3 +/- 475.6 mg/dl, IgA: 242.0 +/- 98.3 mg/dl, IgM 130.4 +/- 95.9 mg/dl). Study on the values of laboratory examinations showed statistically positive correlation between total lymphocyte population and T cell number, and between total lymphocyte population and lymphocyte blast formation. In patients with chyluria, serious sequelae have not been reported. However, care should be taken for possible opportunistic infection and, particularly, malignant tumors because suppression of cellular immunity may be one of the promoting factors of malignant tumors. 相似文献
9.
Somites are formed by periodic segmentation of the presomitic mesoderm (PSM). This periodic event is controlled by the segmentation clock, where Notch signaling plays an essential role. The basic helix-loop-helix factor Hes7, a Notch effector, is cyclically expressed by negative feedback and regulates cyclic expression of Lunatic fringe (Lfng), a Notch modulator. Lfng then seems to periodically inhibit Notch, leading to oscillation in Notch activity. It is thought that these coupled negative feedback loops by Hes7 and Lfng are important for sustained and synchronized oscillations in the PSM. Of interest, another Notch effector, Hes1, is cyclically expressed by many cell types such as neuroblasts, suggesting that this clock is widely distributed and regulates many biological events. This review summarizes the recent finding about roles and mechanism of Notch signaling in the segmentation clock and discusses the significance of Hes1 oscillation in non-PSM cells. 相似文献
10.
Yoshito Tomimaru Ken Kodama Jiro Okami Kazuyuki Oda Koji Takami Masahiko Higashiyama 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(5):193-198
Objective Postoperative pericardial effusion commonly occurs after open heart surgery. However, after general thoracotomy such as pulmonary
resection, there have been few reports of pericardial effusion. The purpose of this study is to investigate patients with
pericardial effusion following pulmonary resection.Methods: Among 2,385 patients with pulmonary resection for lung neoplasm in our institute, eight patients, whose pericardium had
never been opened during the operation, developed pericardial effusion. The clinical characteristics of the eight patients
were analyzed.Results: Pericardial effusion after pulmonary resection was divided into two subtypes: pericardial effusion in three patients with
left thoracotomy occurring within 30 days postoperatively, and pericardial effusion in the remaining five patients with right
thoracotomy occurring more than 30 days postoperatively. Pericardiotomy or pericardiocentesis was performed in three symptomatic
patients, and the remaining five asymptomatic patients were treated with diuretics. Pericardial effusion disappeared in three
of the five patients about 1–3 months after the conservative treatment, while, in the remaining patients, because pericardial
effusion had increased gradually, pericardiocentesis was performed.Conclusion: From our experience, the treatment strategy of drainage for early pericardial effusion and diuretics for late pericardial
effusion seems to be appropriate. (Jpn J Thorac Cardiovasc Surg 2006; 54:193-198) 相似文献