全文获取类型
收费全文 | 2980篇 |
免费 | 110篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 48篇 |
妇产科学 | 71篇 |
基础医学 | 246篇 |
口腔科学 | 36篇 |
临床医学 | 159篇 |
内科学 | 554篇 |
皮肤病学 | 9篇 |
神经病学 | 203篇 |
特种医学 | 118篇 |
外科学 | 1064篇 |
综合类 | 16篇 |
预防医学 | 50篇 |
眼科学 | 37篇 |
药学 | 140篇 |
中国医学 | 2篇 |
肿瘤学 | 348篇 |
出版年
2023年 | 21篇 |
2022年 | 13篇 |
2021年 | 46篇 |
2020年 | 36篇 |
2019年 | 55篇 |
2018年 | 43篇 |
2017年 | 41篇 |
2016年 | 43篇 |
2015年 | 60篇 |
2014年 | 69篇 |
2013年 | 79篇 |
2012年 | 143篇 |
2011年 | 162篇 |
2010年 | 81篇 |
2009年 | 81篇 |
2008年 | 154篇 |
2007年 | 140篇 |
2006年 | 140篇 |
2005年 | 138篇 |
2004年 | 119篇 |
2003年 | 162篇 |
2002年 | 155篇 |
2001年 | 86篇 |
2000年 | 78篇 |
1999年 | 107篇 |
1998年 | 65篇 |
1997年 | 39篇 |
1996年 | 45篇 |
1995年 | 38篇 |
1994年 | 33篇 |
1993年 | 23篇 |
1992年 | 69篇 |
1991年 | 61篇 |
1990年 | 51篇 |
1989年 | 57篇 |
1988年 | 53篇 |
1987年 | 49篇 |
1986年 | 53篇 |
1985年 | 44篇 |
1984年 | 41篇 |
1983年 | 19篇 |
1982年 | 9篇 |
1981年 | 6篇 |
1979年 | 14篇 |
1978年 | 11篇 |
1977年 | 12篇 |
1975年 | 5篇 |
1974年 | 8篇 |
1973年 | 5篇 |
1968年 | 6篇 |
排序方式: 共有3115条查询结果,搜索用时 15 毫秒
1.
Comparative safety study on severe anemia by simeprevir versus telaprevir‐based triple therapy for chronic hepatitis C
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eiichi Ogawa Norihiro Furusyo Eiji Kajiwara Hideyuki Nomura Akira Kawano Kazuhiro Takahashi Kazufumi Dohmen Takeaki Satoh Koichi Azuma Makoto Nakamuta Toshimasa Koyanagi Kazuhiro Kotoh Shinji Shimoda Jun Hayashi The Kyushu University Liver Disease Study Group 《Journal of gastroenterology and hepatology》2015,30(8):1309-1316
2.
3.
Shinsuke Hamaguchi Yasuhisa Okuda Toshimitsu Kitajima Nobuhide Masawa 《Journal canadien d'anesthésie》2002,49(7):745-748
PURPOSE: To clarify the appropriate concentration and dose of hypertonic saline solution (HSS) for preventing delayed neuronal death in the hippocampal CA1 subfield after transient forebrain ischemia in gerbils. METHODS: Thirty gerbils were randomly assigned to five groups: physiological saline solution (PSS) group, ischemia/reperfusion treated with PSS 2 mL x kg(-1); 5% HSS group, treated with 5% HSS 2 mL x kg(-1); 7.5% HSS group, treated with 7.5% HSS 2 mL x kg(-1); 10% HSS group, treated with 10% HSS 2 mL x kg(-1); 20% HSS group, treated with 20% HSS 2 mL x kg(-1). Transient forebrain ischemia was induced by occluding the bilateral common carotid arteries for four minutes. Five days later, histopathological changes in the hippocampal area were examined, and the degenerative ratio of the pyramidal cells were measured according to the following formula: (number of degenerative pyramidal cells/total number of pyramidal cells per 1 mm of hippocampal CA1 subfield) x 100. RESULTS: In PSS and 20% groups, neuronal cell damage was observed five days after ischemia. In the other three groups, these changes were not observed. The degenerative ratios of pyramidal cells were as follows; PSS group: 91.6 +/- 5.6%, 5% HSS group: 7.2 +/- 1.6%, 7.5% group: 8.3 +/- 1.4%, 10% HSS group: 6.2 +/- 1.1%, 20% HSS group: 85.8 +/- 8.7% (P < 0.05; PSS and 20% HSS vs three other groups). CONCLUSION: This study demonstrates that 5, 7.5 or 10% HSS 2 mL x kg(-1) may prevent delayed neuronal death in the hippocampal CA1 subfield after cerebral ischemia/reperfusion in gerbils. 相似文献
4.
S Watanabe K Nakano H Misumi M Yoshikai M Endo A Hashimoto H Koyanagi 《Nihon Geka Gakkai zasshi》1989,90(9):1513-1516
St. Jude Medical valve replacement was performed in 1,039 patients; 320 had aortic (AVR), 543 mitral (MVR), and 176 had double valve replacement (DVR). There were 44(4.2%) early deaths. Follow-up extended in 995 patients from 10 to 130 months, with a cumulative period of 2,730 patients-years. The overall survival rates of AVR, MVR, and DVR patients at 10 years were 60.5%, 89.6%, 90.3% respectively. The linearized incidences of valve thrombosis, thromboembolism, anticoagulation-related hemorrhage, prosthetic valve endocarditis, and significant hemolysis were as follows: 0.11%/pt-yr, 1.33%/pt-yr, 0.04%/pt-yr, 0.18%/pt-yr, and 0.11%/pt-yr, respectively. There were no structural failure after 10 years follow-up. Reoperation (explant and re-replacement or suture repair) was required in 10 patients. Seven of them had periprosthetic leakage, 2 had valve thrombosis, and one underwent reoperation because of a technical error. Actuarially over 98% of patients were free of valve-related mortality at 10 years. St. Jude Medical valve is an excellent alternative for use in the surgical treatment of valvular heart disease. 相似文献
5.
6.
Hypospadias 总被引:1,自引:0,他引:1
T Koyanagi K Nonomura 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1990,81(11):1609-1617
7.
T Harabayashi K Nonomura M Togashi T Seki T Koyanagi 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1990,81(7):1045-1050
We retrospectively reviewed 38 patients with primary penile squamous cell carcinoma (stage 1 in 22, stage 2 in 7 and stage 3 in 9) who were treated in our institution from 1963 through 1987. The incidence of regional nodal metastasis was correlated with tumor category, local infiltration and tumor grade. The incidence rate of nodal metastasis of G2 and G3 tumors was statistically higher than that of G1 tumors. Of 27 patients initially treated by radiotherapy and/or chemotherapy, 11 patients achieved complete response. G1 tumors and T1 to 2 tumors had such high response rates as 58 and 50 per cent, respectively, but 5 patients (45 per cent) had local recurrence at an average of 74 months after initial treatment. The 5-year survival rates of over-all, stage 1, 2 and 3 were 73, 90, 75 and 25 per cent, respectively. Patients with stage 3 disease had a statistical lower survival rate than those with stage 1 or 2 disease. Among 13 patients with regional nodal metastasis, none with G2 tumor survived three years, although 3 patients (60 per cent) of those with G1 tumor survived five years. These results suggest that tumor grade is the most prognostic factor for the regional nodal metastasis, the response of conservative treatment and the survival of metastasized patients. 相似文献
8.
9.
We experienced 5 cases of acute renal failure due to rhabdomyolysis during the last two years and investigated those etiologies. Diagnosis of rhabdomyolysis was established by the detection of elevated serum creatine phosphokinase, myoglobin, aldolase, myoglobinuria as well as by the clinical course. The respective underlying illness of the 5 cases were grand mal seizures, infection (high fever), heat stroke, diabetes mellitus with hyperosmolar nonketotic coma and cerebral infarction treated by barbiturate. In this investigation, however, any single cause was not enough as the etiologies of rhabdomyolysis. There were multiple factors responsible to rhabdomyolysis in each case, such as hypokalemia, hypophosphatemia, shock, arteriosclerosis, etc. Some cases could not be classified as traumatic or non-traumatic rhabdomyolysis. Thus, in one case, acute renal failure due to rhabdomyolysis induced by the combination of grand mal seizures and serum potassium/phosphate depletion. 2 cases recovered without hemodialysis. 3 cases died in multiple organ failure, included a case treated by hemodialysis. We conclude that acute renal failure due to rhabdomyolysis induced easily by numerous diseases and early diagnosis is recommended. 相似文献
10.
Yasuhisa Fujibayashi Hideyuki Taniuchi Kouichi Wada Yoshiharu Yonekura Junji Konishi Akira Yokoyama 《Annals of nuclear medicine》1995,9(1):1-5
The reductive retention of62Cu-PTSM was comparatively studied in the brain and Ehrlich ascites tumor cells by electron spin resonance spectrometry and nonradioactive Cu-PTSM. In the brain, only the mitochondrial fraction showed the ability to reduce Cu-PTSM, and the other subcellular fractions did not. In contrast, the cytosolic fraction of Ehrlich ascites tumor cells was the specific site of Cu-PTSM reduction. It was therefore considered that the retention of Cu-PTSM in the brain is closely related to mitochondrial reduction, most probably involving the mitochondrial electron transport system. 相似文献