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SAMIR R. KAPADIA M.D. SACHIN S. GOEL M.D. UYGAR YUKSEL M.D. SHIKHAR AGARWAL M.D. M.P.H. GOSTA PETTERSSON M.D. LARS G. SVENSSON M.D. NICHOLAS G. SMEDIRA M.D. PATRICK L. WHITLOW M.D. BRUCE W. LYTLE M.D. E. MURAT TUZCU M.D. 《Journal of interventional cardiology》2010,23(5):499-508
Background: Balloon aortic valvuloplasty (BAV) has been used as a bridge to surgical aortic valve replacement (SAVR) in high‐risk patients with severe symptomatic aortic stenosis (AS). Such patients are now being referred for transcatheter aortic valve implantation (TAVI). We sought to study the indications and outcomes of BAV in patients with severe AS in the pre‐TAVI era. Methods: We analyzed consecutive patients with severe AS undergoing BAV from 1990 to 2005. In these patients with no immediate surgical option, BAV was attempted to temporarily improve hemodynamics, with a goal to improve general health of the patient, and ultimately AVR. Results : A total of 99 BAVs (eight repeats, one second repeat) were performed in 90 consecutive patients. Baseline ejection fraction was ≤25% in 36 (36%) patients. The 30‐day mortality rate was 17% (n = 17). Of the 99 patients, 27 (30%) underwent AVR. Average follow‐up of patients with and without AVR was 55 ± 57 months and 16 ± 23 months, respectively. The 6‐month and 1‐year survival rates in patients who underwent AVR were 81% and 78%, respectively, versus 57% and 44% in patients who did not undergo AVR (P = 0.024). Conclusion: BAV can be used successfully to clinically improve the health of some nonsurgical patients with severe symptomatic AS, and a proportion of these patients improve to a point where AVR can be performed. Bridging to TAVI will provide further options to high‐risk patients who cannot be bridged to conventional AVR. The role of BAV in bridging to TAVI merits further study. (J Interven Cardiol 2010;23:499–508) 相似文献
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S SIRRI BILGE YUKSEL KESIM MEHMET KURT ELIF AKSOZ SULEYMAN CELIK 《International journal of urology》2005,12(9):829-834
AIM: To evaluate the effect of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-selective type 5 phosphodiesterase, on isolated rat vas deferens and its connections with the purinergic system. METHODS: Epididymal and prostatic portions of isolated vas deferens were placed in organ baths containing Krebs' solution. Contractions were induced by noradrenaline (NA), adenosine triphosphate (ATP), alpha,beta-methylene ATP and electrical field stimulation (EFS). The effect of sildenafil on the contractions was compared with suramin and Evans blue (EB). RESULTS: NA, ATP, alpha,beta-methylene ATP and EFS caused contractions in both portions of vas deferens. NA-induced contractions were unaffected by sildenafil and suramin but potentiated by EB. ATP-induced contractions were non-competitively inhibited in both portions by sildenafil and suramin but potentiated by EB. alpha,beta-methylene ATP-induced contractions were unaffected by sildenafil but were inhibited in both portions by suramin and EB. EFS-induced contractions were inhibited by sildenafil and suramin while potentiated by EB. CONCLUSION: Sildenafil inhibited the contractions in both portions of vas deferens, as did suramin. We have suggested that purinergic system has a role in this antagonism and it seems to be mediated by an ATP-dependent mechanism instead of a receptor interaction. 相似文献
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Murat YILMAZ Ahmet KARAKASLI Orhan KALEMCI Ceren KIZMAZOGLU Zafer K. YUKSEL Nuri M. ARDA Kemal YUCESOY 《Neurologia medico-chirurgica》2015,55(7):564-569
The present study aimed to evaluate the clinical outcomes of patients who underwent asymmetrical posterior screw fixation for the treatment of unilateral posterior vertebral pathological entities. The study included 21 patients with a spinal tumor who underwent asymmetrical posterior spinal fusion surgery between April 2009 and March 2012. The American Spinal Injury Association (ASIA) motor score visual analog scale (VAS) score were used as the outcome measure at admission and follow-up. Among the 21 patients, 12 were male and 9 were female, and mean age was 50.71 (range, 24–78) years. Mean follow-up was 16.04 (range, 4–47) months. Postoperatively, neurological findings did not deteriorate in any of the patients. Among the ASIA grade C and D patients, eight (38%) of them exhibited clinical stability or recovery to ASIA E, whereas none of the ASIA B patients scores changed postoperatively. Perioperative complications were noted in six patients (28%). Spinal stability and fusion were achieved in 18 (85%) patients. The surgical asymmetrical fixation technique described reduced the duration of surgery, and the patients required less dissection of paraspinal muscles than bilateral symmetrical fixation. Asymmetrical fixation provides good stabilization for unilateral thoracolumbar vertebral pathological entities, and facilitates rapid rehabilitation of such patients, who are often elderly with comorbidities. 相似文献
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Ismail SARI Levent KEBAPCILAR Ali TAYLAN Oktay BILGIR Didem L. KOZACI Yasar YILDIZ Arif YUKSEL Necati GUNAY Nurullah AKKOC 《International journal of rheumatic diseases》2010,13(1):75-81
Aim: Interleukin‐18 (IL‐18) and fetuin‐A have been implicated in atherosclerosis. Preliminary evidence suggests that ankylosing spondylitis (AS) is associated with an increased risk of atherosclerosis. The aim of the present study was to investigate possible abnormalities in IL‐18 and fetuin‐A levels in AS. Methods: Subjects without established cardiovascular (CV) risk factors were studied. Fasting glucose, serum lipids, high sensitive C‐reactive protein (hsCRP), erythrocyte sedimentation rate, IL‐18 and fetuin‐A were assessed. Patients were also evaluated with the Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Functional Index, and the Bath Ankylosing Spondylitis Disease Activity Index. Results: Fourty‐five patients with AS (37.4 ± 9.7 years; 35M/10F) and 29 controls (35.5 ± 11.1 years; 21M/8F) were studied. Fetuin‐A levels were significantly higher in AS patients compared to controls (1023.5 ± 171.6 vs. 856.9 ± 207.9 μg/mL, P < 0.001). IL‐18 levels were also higher in the AS group but the difference was not significant (184 ± 186 vs. 140 ± 115, P = 0.1). Significant but weak correlations were found between fetuin‐A, IL‐18, hsCRP, low density lipoprotein cholesterol, and triglyceride levels (P < 0.05; r = 0.4, 0.3, 0.2, and 0.3 respectively). Comparison of subjects with respect to the treatment type, disease activity and history of peripheral arthritis yielded no difference regarding fetuin‐A and IL‐18 between groups. Conclusion: Fetuin‐A and IL‐18 levels seem to be increased in AS patients regardless of disease activity and treatment type. 相似文献
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Reversible Myoglobinuric Renal Failure Following Rhabdomyolysis as a Rare Complication of Cardioversion 总被引:2,自引:0,他引:2
YUKSEL CAVUSOGLU EMRE ENTOK BULENT GORENEK GULMIRA KUDAIBERDIEVA AHMET UNALIR OMER GOKTEKIN ALPARSLAN BIRDANE NECMI ATA BILGIN TIMURALP 《Pacing and clinical electrophysiology : PACE》2003,26(2P1):645-646
CAVUSOGLU, Y., et al .: Reversible Myoglobinuric Renal Failure Following Rhabdomyolysis as a Rare Complication of Cardioversion. Reversible myoglobinuric renal failure following rhabdomyolysis that was related to repeated countershocks delivered for the treatment of refractory recurrent VT and VF attacks during acute myocardial infarction is presented in this case report, in which scan with technetium-99m pyrophosphate has been used for in the diagnosis of extensive skeletal muscle damage. (PACE 2003; 26[Pt. I]:645–646) 相似文献
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SEMA MISIR SERAP OZER YAMAN NINA PETROVIĆ CEREN SUMER CEYLAN HEPOKUR YUKSEL ALIYAZICIOGLU 《Oncology research》2022,30(4):157-172
Breast cancer (BC) is the most common heterogeneous disease in women and one of the leading causes of
cancer-related death. Surgery, chemotherapy, radiotherapy, hormone, and targeted therapy are the gold standards for
BC treatment. One of the significant challenges during the treatment of BC represents resistance to
chemotherapeutics, resistance that severely limits the use and effectiveness of the drugs used for BC treatment.
Therefore, it is essential to develop new strategies to improve therapeutic efficacy. Circular RNAs (circRNAs) are a
large group of non-coding RNAs that covalently form closed circular loops by joining their 5′, and 3′; ends.
Accumulating evidence suggests that circRNAs have a vital role in cancer development, progression, and BC
resistance to chemotherapy. The purpose of this review is to discuss the biological properties of circRNAs, and how
circRNAs induce resistance to conventional therapeutic anti-cancer drugs used in BC treatment, by emphasizing and
summarizing the potential roles of circRNAs in mechanisms of drug resistance, such as drug efflux, apoptosis
dysfunction, autophagy, and DNA damage repair. CircRNAs are associated with drug resistance via ATP-binding
cassette (ABC) efflux transporters, while some others by inhibition of cell apoptosis, thus leading to resistance to
tamoxifen in BC cells. In contrast, others are involved in the promotion of BC cells chemoresistance by doxorubicininduced autophagy. CircRNAs may have clinical significance in regulating or overcoming BC drug resistance and may
give directions towards a novel approach to personalized BC treatment. CircRNAs may significantly contribute to the
identification of new therapeutic targets for the prevention of BC chemoresistance. 相似文献
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Fuat OZKAN Perihan OZTURK Kemal OZYURT Mehmet F. İNCİ Ali M. KALENDER Betul BAKAN Murvet YUKSEL 《The Journal of dermatology》2013,40(2):107-110
Onychomycosis in toenails is a common fungal infection and vascular abnormalities of lower extremities have been thought as one of the predisposing conditions. The aim of this study was to evaluate predisposition effect of venous insufficiency and peripheral arterial disease on toenail onychomycosis. Thirty‐three patients with bilateral onychomycosis in toenails and 37 control subjects, who had healthy nails, were enrolled in the study. Veins and arteries of lower extremities were examined with Doppler ultrasound in terms of venous insufficiency or peripheral arterial disease. Patients with onychomycosis presented more frequent venous insufficiency than the control group (42.4% and 10.8%, respectively; P = 0.003). Although all patients had bilateral onychomycosis, reflux was bilateral in six out of 14 patients with onychomycosis (42.8%). No significant difference in frequency of peripheral arterial disease was found in patients, compared to healthy controls. Our study demonstrated a significant relationship between onychomycosis and venous insufficiency, but not with peripheral arterial disease. Also, we point out discordance with bilateral onychomycosis and unilateral venous insufficiency. 相似文献
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CAN HASDEMIR OZCAN VURAN ALPER YUKSEL OGUZ YAVUZGIL 《Pacing and clinical electrophysiology : PACE》2013,36(4):e111-e114
We present a case of 38‐year‐old woman with stress cardiomyopathy presenting to the emergency department with a 1‐week history of recurrent syncope due to sustained polymorphic ventricular tachycardia. 相似文献
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In this study, microspheres were prepared by the spray drying technique using suspensions of indomethacin (IM) as active substance and coated by three different polymers in order to increase the dissolution rate of IM. Water solutions (0.1, 0.2 and 0.5%) of hydroxypropylmethyl cellulose (HPMC), polyvinyl alcohol (PVA) and hydroxypropyl cellulose (HPC) were used as coating materials. Polyethylene glycol 400 (PEG 400) was added to all formulations as plasticizer. Changes of particles size and surface characteristics of the coated products were examined using optical microscopy and scanning electron microscopy (SEM), respectively. The effects of coatings on the dissolution rates of IM were examined using USP XXIII Method II in water and phosphate buffer pH 7.4. It was observed that coating the IM particles with HPMC, PVA and HPC polymers using the Spray-Drying Technique increased the dissolution rate of IM significantly. 相似文献
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